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Coexpression cluster:C2245

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Full id: C2245_Mast_CD14_Synoviocyte_Neutrophils_Dendritic_CD14CD16_Whole



Phase1 CAGE Peaks

Hg19::chr12:8276189..8276197,+p6@CLEC4A
Hg19::chr1:158801195..158801202,+p5@MNDA
Hg19::chr7:76829125..76829143,-p1@FGL2
Hg19::chr7:76829145..76829167,-p2@FGL2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005577fibrinogen complex0.0476751007987573



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte4.52e-41136
myeloid leukocyte7.35e-4072
granulocyte monocyte progenitor cell6.16e-3567
macrophage dendritic cell progenitor7.28e-3561
nongranular leukocyte3.48e-34115
monopoietic cell1.38e-3359
monocyte1.38e-3359
monoblast1.38e-3359
promonocyte1.38e-3359
hematopoietic lineage restricted progenitor cell1.99e-33120
defensive cell2.26e-3348
phagocyte2.26e-3348
hematopoietic stem cell1.11e-32168
angioblastic mesenchymal cell1.11e-32168
myeloid lineage restricted progenitor cell1.03e-3166
classical monocyte2.17e-3042
CD14-positive, CD16-negative classical monocyte2.17e-3042
hematopoietic oligopotent progenitor cell2.61e-30161
hematopoietic multipotent progenitor cell2.61e-30161
hematopoietic cell3.94e-29177
myeloid cell7.97e-27108
common myeloid progenitor7.97e-27108
stuff accumulating cell3.80e-1587
intermediate monocyte4.50e-089
CD14-positive, CD16-positive monocyte4.50e-089
mesenchymal cell5.69e-08354
granulocyte2.14e-078
connective tissue cell5.49e-07361
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.73e-3798
blood island2.73e-3798
adult organism2.11e-36114
hemolymphoid system4.16e-32108
bone marrow1.30e-2976
bone element1.10e-2582
immune system7.98e-2593
skeletal element1.38e-2090
lateral plate mesoderm3.41e-19203
skeletal system1.38e-18100
musculoskeletal system2.69e-13167
tissue1.30e-09773
mesoderm6.70e-09315
mesoderm-derived structure6.70e-09315
presumptive mesoderm6.70e-09315
neural tube8.99e-0956
neural rod8.99e-0956
future spinal cord8.99e-0956
neural keel8.99e-0956
blood2.08e-0815
haemolymphatic fluid2.08e-0815
organism substance2.08e-0815
regional part of nervous system9.87e-0853
regional part of brain9.87e-0853
regional part of forebrain6.19e-0741
forebrain6.19e-0741
anterior neural tube6.19e-0741
future forebrain6.19e-0741


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.11.66718
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.21.37305
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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