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Coexpression cluster:C1092

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Full id: C1092_Hepatic_CD8_CD4_Endothelial_Renal_lymph_spleen



Phase1 CAGE Peaks

Hg19::chr7:150147807..150147847,+p1@GIMAP8
Hg19::chr7:150147877..150147898,+p3@GIMAP8
Hg19::chr7:150147899..150147910,+p7@GIMAP8
Hg19::chr7:150147930..150147943,+p4@GIMAP8
Hg19::chr7:150329353..150329364,-p7@GIMAP6
Hg19::chr7:150329389..150329412,-p3@GIMAP6
Hg19::chr7:150329421..150329482,-p1@GIMAP6
Hg19::chr7:150329530..150329552,-p2@GIMAP6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005525GTP binding0.00118477953347309
GO:0032561guanyl ribonucleotide binding0.00118477953347309
GO:0019001guanyl nucleotide binding0.00118477953347309
GO:0032553ribonucleotide binding0.0133979824776932
GO:0032555purine ribonucleotide binding0.0133979824776932
GO:0017076purine nucleotide binding0.0133979824776932
GO:0000166nucleotide binding0.0157508168628174



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell2.33e-21172
angioblastic mesenchymal cell2.33e-21172
nongranular leukocyte2.45e-21119
leukocyte4.61e-21140
endothelial cell3.12e-2035
hematopoietic oligopotent progenitor cell7.46e-20165
hematopoietic multipotent progenitor cell7.46e-20165
hematopoietic lineage restricted progenitor cell1.50e-19124
hematopoietic cell1.31e-18182
endothelial cell of vascular tree1.61e-1824
blood vessel endothelial cell1.33e-1418
embryonic blood vessel endothelial progenitor cell1.33e-1418
monopoietic cell5.19e-1463
monocyte5.19e-1463
monoblast5.19e-1463
promonocyte5.19e-1463
myeloid lineage restricted progenitor cell1.14e-1370
myeloid leukocyte1.50e-1376
macrophage dendritic cell progenitor1.99e-1365
meso-epithelial cell2.95e-1344
granulocyte monocyte progenitor cell3.92e-1371
myeloid cell6.26e-13112
common myeloid progenitor6.26e-13112
CD14-positive, CD16-negative classical monocyte6.31e-1342
classical monocyte4.57e-1145
mature alpha-beta T cell1.03e-1018
alpha-beta T cell1.03e-1018
immature T cell1.03e-1018
mature T cell1.03e-1018
immature alpha-beta T cell1.03e-1018
T cell7.26e-1025
pro-T cell7.26e-1025
CD8-positive, alpha-beta T cell4.09e-0811
endothelial cell of artery4.66e-089
lining cell2.61e-0757
barrier cell2.61e-0757
lymphoid lineage restricted progenitor cell4.78e-0752
lymphocyte4.81e-0753
common lymphoid progenitor4.81e-0753


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.