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Coexpression cluster:C3384

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Full id: C3384_lung_amniotic_signet_papillotubular_prostate_gall_Hepatocyte



Phase1 CAGE Peaks

Hg19::chr13:76334798..76334809,+p20@LMO7
Hg19::chr13:76334824..76334862,+p2@LMO7
Hg19::chr13:76334880..76334887,+p34@LMO7


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell8.65e-12253
endodermal cell1.94e-1158
endo-epithelial cell1.00e-0942
Uber Anatomy
Ontology termp-valuen
subdivision of digestive tract1.54e-22118
digestive system7.21e-22145
digestive tract7.21e-22145
primitive gut7.21e-22145
endoderm-derived structure9.17e-22160
endoderm9.17e-22160
presumptive endoderm9.17e-22160
respiratory tract9.73e-2054
foregut3.48e-1987
organ system subdivision3.41e-18223
respiratory primordium7.12e-1738
endoderm of foregut7.12e-1738
adult organism7.20e-17114
respiratory system8.98e-1774
endo-epithelium1.98e-1582
segment of respiratory tract8.61e-1547
multi-tissue structure2.79e-13342
epithelial bud6.99e-1237
organ part8.83e-11218
epithelial fold3.96e-1047
cerebral hemisphere3.99e-1032
upper respiratory tract6.41e-1019
regional part of forebrain8.45e-1041
forebrain8.45e-1041
anterior neural tube8.45e-1041
future forebrain8.45e-1041
thoracic segment organ1.28e-0935
organ2.91e-09503
lung3.53e-0922
respiratory tube3.53e-0922
respiration organ3.53e-0922
pair of lungs3.53e-0922
lung primordium3.53e-0922
lung bud3.53e-0922
telencephalon3.81e-0934
regional part of telencephalon4.02e-0932
anatomical cluster4.84e-09373
thoracic cavity element4.92e-0934
thoracic cavity4.92e-0934
gut epithelium6.06e-0954
larynx6.15e-099
trunk region element1.45e-08101
anatomical conduit2.50e-08240
regional part of cerebral cortex2.78e-0822
brain grey matter3.16e-0834
gray matter3.16e-0834
primordium2.11e-07160
neocortex5.07e-0720
immaterial anatomical entity5.26e-07117
cerebral cortex8.92e-0725
pallium8.92e-0725
Disease
Ontology termp-valuen
carcinoma1.65e-21106
cell type cancer4.94e-12143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553344.87181354697741.10603738662898e-050.000284026158402125
CEBPB#105137.971147625824820.001974187055288560.0115044147900503
CTCF#1066435.360256373075030.0064925092527670.0278777771594677
EP300#203336.77394172622320.003216880500103790.0167131520520515
FOXA1#3169311.08141974938550.000734755275698670.00580155033179809
FOXA2#3170324.63046375266526.68983856509345e-050.00107110233006254
GTF2F1#2962312.73966087675770.0004835525047438590.00433119554399176
HDAC2#3066313.41562023662630.0004140761399857210.0039037459815823
HNF4A#3172323.13229036295378.07584663437677e-050.001226277037871
HNF4G#3174328.75342252644684.20470658818262e-050.000755566674747427
MAFF#23764356.31535648994525.59409009993116e-060.000168855831198471
MAFK#7975327.10073313782995.02195559325033e-050.000856586673531719
NR3C1#2908314.9730233311730.0002978331194675480.00308279416888714
RAD21#5885310.35503389545630.0009004912073565420.00662671936338147
RFX5#5993312.04791082719510.0005717246050312580.00483562892977483
RXRA#6256320.07461713913330.0001235730348432220.00165015268968052
SIN3A#2594235.408884726815140.006318961977991520.0275885652781847
SMC3#9126315.04493284493280.0002935825420371870.00308465463861386
SP1#666735.69838137814090.005403962701712170.0245854879161926
STAT3#6774310.51946499715420.0008589184530415310.00641847340563856
TCF7L2#6934310.77017656313730.0008003181298398380.00612429844389968



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.