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Coexpression cluster:C3526

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Full id: C3526_CD14_immature_Dendritic_small_Mast_pancreas_ductus



Phase1 CAGE Peaks

Hg19::chr15:86122462..86122472,+p@chr15:86122462..86122472
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Hg19::chr15:86122485..86122494,+p@chr15:86122485..86122494
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Hg19::chr15:86122496..86122511,+p@chr15:86122496..86122511
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
granulocyte monocyte progenitor cell1.22e-5767
macrophage dendritic cell progenitor2.43e-5461
myeloid leukocyte1.07e-5372
monopoietic cell6.69e-5259
monocyte6.69e-5259
monoblast6.69e-5259
promonocyte6.69e-5259
myeloid lineage restricted progenitor cell7.27e-5266
defensive cell1.62e-4748
phagocyte1.62e-4748
myeloid cell4.83e-42108
common myeloid progenitor4.83e-42108
classical monocyte6.35e-4242
CD14-positive, CD16-negative classical monocyte6.35e-4242
leukocyte5.21e-32136
hematopoietic stem cell2.31e-26168
angioblastic mesenchymal cell2.31e-26168
hematopoietic lineage restricted progenitor cell1.10e-24120
hematopoietic cell1.47e-23177
nongranular leukocyte4.29e-23115
hematopoietic oligopotent progenitor cell6.79e-23161
hematopoietic multipotent progenitor cell6.79e-23161
stuff accumulating cell1.26e-1987
dendritic cell1.98e-1210
conventional dendritic cell2.97e-108
immature conventional dendritic cell2.56e-075
common dendritic progenitor2.56e-075
macrophage7.34e-076
Langerhans cell7.51e-075
Uber Anatomy
Ontology termp-valuen
bone marrow1.52e-4976
hematopoietic system7.97e-4598
blood island7.97e-4598
bone element4.43e-4482
immune system1.66e-4393
hemolymphoid system1.78e-40108
skeletal element5.83e-3890
skeletal system8.71e-33100
adult organism3.42e-24114
lateral plate mesoderm2.24e-20203
musculoskeletal system3.44e-15167
organ4.40e-11503
mesoderm1.14e-10315
mesoderm-derived structure1.14e-10315
presumptive mesoderm1.14e-10315
germ layer1.15e-08560
germ layer / neural crest1.15e-08560
embryonic tissue1.15e-08560
presumptive structure1.15e-08560
germ layer / neural crest derived structure1.15e-08560
epiblast (generic)1.15e-08560
developing anatomical structure1.90e-08581
embryonic structure2.56e-08564
embryo7.36e-08592
anatomical system9.57e-07624


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
NR3C1#2908314.9730233311730.0002978331194675480.00308462843753186
SPI1#668838.204323508522730.001810593189410520.0108970519281303



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.