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Coexpression cluster:C3551

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Full id: C3551_acute_Mast_biphenotypic_leukemia_embryonic_small_CD14



Phase1 CAGE Peaks

Hg19::chr16:28995993..28996015,-p1@CU678918
Hg19::chr16:28996019..28996030,-p3@CU678918
Hg19::chr16:28996032..28996043,-p4@CU678918


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell4.86e-38168
angioblastic mesenchymal cell4.86e-38168
hematopoietic oligopotent progenitor cell3.41e-37161
hematopoietic multipotent progenitor cell3.41e-37161
hematopoietic cell2.71e-35177
myeloid cell4.67e-34108
common myeloid progenitor4.67e-34108
leukocyte1.18e-28136
hematopoietic lineage restricted progenitor cell8.04e-28120
myeloid leukocyte1.72e-2772
myeloid lineage restricted progenitor cell8.50e-2766
granulocyte monocyte progenitor cell2.87e-2667
nongranular leukocyte1.09e-22115
defensive cell5.22e-2048
phagocyte5.22e-2048
monopoietic cell5.23e-2059
monocyte5.23e-2059
monoblast5.23e-2059
promonocyte5.23e-2059
classical monocyte1.63e-1942
CD14-positive, CD16-negative classical monocyte1.63e-1942
macrophage dendritic cell progenitor4.00e-1961
histamine secreting cell5.71e-145
biogenic amine secreting cell5.71e-145
granulocytopoietic cell5.71e-145
mast cell5.71e-145
mast cell progenitor5.71e-145
basophil mast progenitor cell5.71e-145
mesenchymal cell3.58e-11354
connective tissue cell1.16e-10361
T cell3.63e-1025
pro-T cell3.63e-1025
motile cell5.80e-10386
stuff accumulating cell2.46e-0887
endocrine cell1.68e-079
mature alpha-beta T cell8.65e-0718
alpha-beta T cell8.65e-0718
immature T cell8.65e-0718
mature T cell8.65e-0718
immature alpha-beta T cell8.65e-0718
multi fate stem cell9.31e-07427
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.57e-2698
blood island1.57e-2698
hemolymphoid system4.44e-23108
bone marrow3.87e-2276
immune system6.15e-2293
bone element6.80e-2082
skeletal element2.26e-1790
skeletal system8.40e-15100
connective tissue1.51e-10371
thymus6.12e-094
hemolymphoid system gland6.12e-094
thymic region6.12e-094
pharyngeal gland6.12e-094
thymus primordium6.12e-094
lateral plate mesoderm3.18e-08203
Disease
Ontology termp-valuen
leukemia3.96e-1839
hematologic cancer1.06e-1551
immune system cancer1.06e-1551
myeloid leukemia4.71e-1531


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.