MCL coexpression mm9:1223

Phase1 CAGE Peaks

	Short description
Mm9::chr10:126602348..126602359,+	p11@B4galnt1
Mm9::chr10:126602369..126602383,+	p5@B4galnt1
Mm9::chr10:126602843..126602860,+	p7@B4galnt1
Mm9::chr10:126602861..126602878,+	p6@B4galnt1
Mm9::chr10:126602881..126602956,+	p2@B4galnt1
Mm9::chr17:46300102..46300132,+	p6@Gtpbp2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003947	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity	0.00777954308880732
GO:0001574	ganglioside biosynthetic process	0.00972203131937673
GO:0030259	lipid glycosylation	0.00972203131937673
GO:0006688	glycosphingolipid biosynthetic process	0.00972203131937673
GO:0001573	ganglioside metabolic process	0.00972203131937673
GO:0009247	glycolipid biosynthetic process	0.00972203131937673
GO:0019915	sequestering of lipid	0.00972203131937673
GO:0006687	glycosphingolipid metabolic process	0.00972203131937673
GO:0030148	sphingolipid biosynthetic process	0.0121475442708201
GO:0006664	glycolipid metabolic process	0.0121475442708201
GO:0008376	acetylgalactosaminyltransferase activity	0.0121475442708201
GO:0006672	ceramide metabolic process	0.0121475442708201
GO:0030258	lipid modification	0.0121475442708201
GO:0030173	integral to Golgi membrane	0.0121475442708201
GO:0046519	sphingoid metabolic process	0.0121475442708201
GO:0031228	intrinsic to Golgi membrane	0.0121475442708201
GO:0006665	sphingolipid metabolic process	0.0191984603543554
GO:0031301	integral to organelle membrane	0.0215808346195295
GO:0031300	intrinsic to organelle membrane	0.0224864167838657
GO:0000139	Golgi membrane	0.0266208409274459
GO:0046467	membrane lipid biosynthetic process	0.0266208409274459
GO:0043413	biopolymer glycosylation	0.0278759404793481
GO:0008194	UDP-glycosyltransferase activity	0.0290209928853652
GO:0044431	Golgi apparatus part	0.0402455026940035
GO:0003924	GTPase activity	0.0402455026940035
GO:0016758	transferase activity, transferring hexosyl groups	0.0402455026940035
GO:0006643	membrane lipid metabolic process	0.0433290354045682

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	4.60e-10	32
hematopoietic oligopotent progenitor cell	4.60e-10	32
hematopoietic stem cell	4.60e-10	32
angioblastic mesenchymal cell	4.60e-10	32
hematopoietic multipotent progenitor cell	4.60e-10	32
hematopoietic lineage restricted progenitor cell	3.43e-09	25
connective tissue cell	2.23e-08	46
mesenchymal cell	2.23e-08	46
lymphoid lineage restricted progenitor cell	3.67e-08	12
T cell	7.09e-08	11
pro-T cell	7.09e-08	11
leukocyte	1.64e-07	17
nongranular leukocyte	1.64e-07	17
mature alpha-beta T cell	1.83e-07	9
alpha-beta T cell	1.83e-07	9
immature T cell	1.83e-07	9
mature T cell	1.83e-07	9
immature alpha-beta T cell	1.83e-07	9
lymphocyte	5.60e-07	13
common lymphoid progenitor	5.60e-07	13
CD4-positive, alpha-beta T cell	8.79e-07	8

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	2.95e-22	118
endoderm	2.95e-22	118
presumptive endoderm	2.95e-22	118
digestive system	9.65e-22	116
digestive tract	9.65e-22	116
primitive gut	9.65e-22	116
subdivision of digestive tract	1.76e-20	114
hemolymphoid system	1.19e-13	48
immune system	1.19e-13	48
gastrointestinal system	2.16e-13	47
gut epithelium	5.03e-13	55
hematopoietic system	5.67e-12	45
blood island	5.67e-12	45
intestine	1.06e-11	31
organ component layer	7.81e-11	24
endo-epithelium	2.90e-10	69
mucosa	4.39e-10	15
unilaminar epithelium	1.31e-09	66
foregut	5.38e-09	80
intestinal mucosa	7.22e-09	13
anatomical wall	7.22e-09	13
wall of intestine	7.22e-09	13
gastrointestinal system mucosa	7.22e-09	13
connective tissue	2.23e-08	46
mixed endoderm/mesoderm-derived structure	6.81e-08	35
hemopoietic organ	1.18e-07	29
immune organ	1.18e-07	29
gland of gut	4.93e-07	24
segment of respiratory tract	5.06e-07	27
adult organism	5.60e-07	51
thymus	7.02e-07	23
neck	7.02e-07	23
respiratory system epithelium	7.02e-07	23
hemolymphoid system gland	7.02e-07	23
pharyngeal epithelium	7.02e-07	23
thymic region	7.02e-07	23
pharyngeal gland	7.02e-07	23
entire pharyngeal arch endoderm	7.02e-07	23
thymus primordium	7.02e-07	23
early pharyngeal endoderm	7.02e-07	23
pharynx	7.34e-07	24
upper respiratory tract	7.34e-07	24
chordate pharynx	7.34e-07	24
pharyngeal arch system	7.34e-07	24
pharyngeal region of foregut	7.34e-07	24

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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