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Coexpression cluster:C3793

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Full id: C3793_iPS_testicular_Alveolar_Burkitt_transitionalcell_neuroblastoma_small



Phase1 CAGE Peaks

  Short description
Hg19::chr19:41257160..41257167,+ p6@SNRPA
Hg19::chr19:41257173..41257187,+ p4@SNRPA
Hg19::chr19:41257196..41257214,+ p5@SNRPA


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
epithelial cell3.17e-27253
animal cell4.43e-20679
eukaryotic cell4.43e-20679
embryonic cell9.91e-14250
native cell2.39e-13722
epithelial cell of nephron5.22e-0815
neural cell2.33e-0725
kidney cell4.79e-0717
kidney epithelial cell4.79e-0717
ectodermal cell4.91e-0772
squamous epithelial cell6.89e-0763
Uber Anatomy
Ontology termp-valuen
nephron epithelium5.22e-0815
renal tubule5.22e-0815
nephron tubule5.22e-0815
nephron5.22e-0815
uriniferous tubule5.22e-0815
nephrogenic mesenchyme5.22e-0815
excretory tube2.36e-0716
kidney epithelium2.36e-0716
cortex4.12e-0715
Disease
Ontology termp-valuen
cancer1.92e-40235
disease of cellular proliferation8.39e-39239
cell type cancer1.58e-22143
organ system cancer3.60e-18137
carcinoma6.23e-18106
hematologic cancer4.33e-1351
immune system cancer4.33e-1351
leukemia1.69e-1039
germ cell and embryonal cancer9.94e-1022
germ cell cancer9.94e-1022
myeloid leukemia3.11e-0831


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.11.55947
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.13.943
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.10.273764
MA0146.11.16674
MA0147.12.37462
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.22.07067
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.122425
MA0164.11.01792
MA0080.21.55139
MA0018.20.987913
MA0099.20.902716
MA0079.20.0107199
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672320.18423064322380.0001215704860271640.0016420977742099
CHD2#1106310.34402283411690.0009033701102746880.00660323844813677
E2F1#186934.907389214879320.008460985347239390.0325352300692318
E2F4#1874312.66806031528440.0004917987006298980.00437094413199608
E2F6#187635.017155731697390.00791769806886330.0322171063472168
EGR1#195834.988179094810140.008056488137383440.0320562162671514
ELF1#199734.258097958807540.01295179875054610.0462231038035909
ETS1#211339.728760922202340.001085840092584840.00762072800413062
GABPB1#255337.067683836182170.002832212825417420.0154075151200005
GTF2F1#2962312.73966087675770.0004835525047438590.00433826475757615
HMGN3#932438.178547723350590.001827766942164210.0108688806965034
IRF1#365937.63716375356390.002244692747297240.0128056735584736
MAX#414936.452555509007120.003721913834265510.0186477792725764
MXI1#460139.96157162875930.001011470541259020.00720235711860305
MYC#460935.22228187160940.007020843755740150.0294454220948416
NFKB1#479035.488063424193840.006049381815655430.0269593081905371
NFYA#4800318.42558069983050.0001598135507814160.00199602576298258
PAX5#507936.669565531177830.003370290999677260.017289150828395
POU2F2#545239.106124057742520.001324165192682130.00882205208972499
RXRA#6256320.07461713913330.0001235730348432220.00165226529074271
SIN3A#2594235.408884726815140.006318961977991520.0276695346115239
SIX5#147912317.0867153554590.0002004060546325010.00239668017173523
SP1#666735.69838137814090.005403962701712170.0246445334528674
SPI1#668838.204323508522730.001810593189410520.010907108617918
SRF#6722313.79717826216780.0003806615025800190.00375055723282591
TAF7#6879311.43306940492390.0006690181981945830.00542860629331397
USF1#739136.361499277207960.00388404057290560.0190247309536483
YY1#752834.911170749853860.008441455341808260.0329330278088574
ZBTB33#10009331.66472502998123.14815888737575e-050.000633874235663459
ZNF143#7702313.50087655222790.0004062804962997170.00388923269963759



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.