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Coexpression cluster:C2128

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Full id: C2128_normal_CD14_leiomyoma_Fibroblast_signet_tenocyte_Synoviocyte



Phase1 CAGE Peaks

Hg19::chr11:35250868..35250884,+p@chr11:35250868..35250884
+
Hg19::chr11:35250931..35250946,+p@chr11:35250931..35250946
+
Hg19::chr11:35251773..35251789,+p4@CD44
Hg19::chr11:35252179..35252192,+p14@CD44


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
somatic cell3.58e-21591
native cell1.02e-17722
myeloid leukocyte8.28e-1776
granulocyte monocyte progenitor cell1.89e-1671
animal cell2.39e-16679
eukaryotic cell2.39e-16679
myeloid lineage restricted progenitor cell4.37e-1670
macrophage dendritic cell progenitor1.01e-1565
monopoietic cell1.07e-1563
monocyte1.07e-1563
monoblast1.07e-1563
promonocyte1.07e-1563
CD14-positive, CD16-negative classical monocyte1.33e-1542
somatic stem cell2.04e-15436
multi fate stem cell2.68e-15430
classical monocyte1.81e-1445
non-terminally differentiated cell1.92e-13180
stem cell2.09e-13444
connective tissue cell4.39e-12365
motile cell1.44e-11390
mesenchymal cell2.15e-11358
fibroblast6.93e-0875
smooth muscle cell1.26e-0742
smooth muscle myoblast1.26e-0742
hematopoietic lineage restricted progenitor cell2.35e-07124
skin fibroblast5.27e-0723
myeloid cell5.28e-07112
common myeloid progenitor5.28e-07112
nongranular leukocyte8.81e-07119
Uber Anatomy
Ontology termp-valuen
musculoskeletal system2.12e-19167
bone marrow3.25e-1680
bone element1.05e-1386
skeletal element1.12e-13101
skeletal system1.12e-13101
hematopoietic system4.68e-13102
blood island4.68e-13102
connective tissue3.40e-11375
hemolymphoid system3.29e-10112
surface structure4.63e-0995
lateral plate mesoderm6.45e-08216
integument9.01e-0845
integumental system9.01e-0845
multilaminar epithelium4.78e-0782
skin of body5.73e-0740


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.