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Coexpression cluster:C1936

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Full id: C1936_Wilms_extraskeletal_Skeletal_uterus_cervix_lung_salivary



Phase1 CAGE Peaks

  Short description
Hg19::chr4:148402078..148402099,+ p4@EDNRA
Hg19::chr4:148402109..148402132,+ p2@EDNRA
Hg19::chr4:148402212..148402230,+ p3@EDNRA
Hg19::chr4:148402237..148402276,+ p1@EDNRA
Hg19::chr4:148402291..148402302,+ p5@EDNRA


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
fibroblast1.09e-0976
contractile cell8.03e-0959
muscle precursor cell2.20e-0858
myoblast2.20e-0858
multi-potent skeletal muscle stem cell2.20e-0858
muscle cell5.66e-0855
electrically responsive cell4.13e-0761
electrically active cell4.13e-0761
Uber Anatomy
Ontology termp-valuen
multi-tissue structure2.97e-24342
anatomical cluster9.76e-15373
multi-cellular organism1.01e-13656
adult organism1.40e-13114
dense mesenchyme tissue1.78e-1273
paraxial mesoderm4.33e-1272
presumptive paraxial mesoderm4.33e-1272
somite5.20e-1271
presomitic mesoderm5.20e-1271
presumptive segmental plate5.20e-1271
dermomyotome5.20e-1271
trunk paraxial mesoderm5.20e-1271
structure with developmental contribution from neural crest7.08e-12132
organism subdivision1.63e-11264
surface structure9.12e-1199
anatomical system1.07e-10624
cell layer1.42e-10309
anatomical group1.56e-10625
muscle tissue1.56e-1064
musculature1.56e-1064
musculature of body1.56e-1064
epithelial vesicle1.99e-1078
multilaminar epithelium3.54e-1083
skeletal muscle tissue6.87e-1062
striated muscle tissue6.87e-1062
myotome6.87e-1062
embryo1.07e-09592
epithelium1.20e-09306
developing anatomical structure1.59e-09581
embryonic structure2.39e-09564
tissue3.12e-09773
ectoderm-derived structure5.53e-09171
ectoderm5.53e-09171
presumptive ectoderm5.53e-09171
organ system subdivision5.77e-09223
germ layer7.48e-09560
germ layer / neural crest7.48e-09560
embryonic tissue7.48e-09560
presumptive structure7.48e-09560
germ layer / neural crest derived structure7.48e-09560
epiblast (generic)7.48e-09560
mesenchyme9.38e-09160
entire embryonic mesenchyme9.38e-09160
organ1.43e-07503
trunk mesenchyme3.06e-07122
anterior region of body3.31e-0762
craniocervical region3.31e-0762
neurectoderm3.61e-0786


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.11.98392
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.12.17648
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.11.76068
MA0139.10.277033
MA0140.10.692258
MA0141.12.22808
MA0142.10.912455
MA0143.10.797437
MA0144.13.47082
MA0145.10.868598
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.21.41695
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.11.91168
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.12.67024
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.168633
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.0442129
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TCF7L2#6934510.77017656313736.89693748574565e-060.000200085903909386
ZNF263#1012758.221841637010682.6606316672286e-050.000572109760538786



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.