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Coexpression cluster:C2581

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Full id: C2581_Renal_Endothelial_extraskeletal_Hepatic_Lymphatic_Mesenchymal_Smooth



Phase1 CAGE Peaks

  Short description
Hg19::chr1:32538492..32538508,+ p2@TMEM39B
Hg19::chr4:145567043..145567058,- p3@ENST00000503066
Hg19::chr4:145567059..145567099,- p1@ENST00000503066
Hg19::chr4:145567114..145567191,- p1@LOC646576


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
vasculature2.29e-3578
vascular system2.29e-3578
anatomical cluster1.12e-31373
vessel8.48e-3168
cell layer1.50e-30309
epithelium2.75e-29306
tube7.59e-29192
epithelial tube open at both ends5.10e-2859
blood vessel5.10e-2859
blood vasculature5.10e-2859
vascular cord5.10e-2859
splanchnic layer of lateral plate mesoderm5.65e-2883
anatomical conduit5.47e-27240
cardiovascular system2.46e-26109
epithelial tube4.07e-26117
circulatory system2.45e-24112
artery5.87e-2242
arterial blood vessel5.87e-2242
arterial system5.87e-2242
unilaminar epithelium5.34e-20148
multi-tissue structure1.66e-19342
epithelial vesicle4.90e-1978
systemic artery6.52e-1733
systemic arterial system6.52e-1733
muscle tissue1.32e-1664
musculature1.32e-1664
musculature of body1.32e-1664
skeletal muscle tissue2.20e-1662
striated muscle tissue2.20e-1662
myotome2.20e-1662
dense mesenchyme tissue8.23e-1673
mesenchyme1.16e-15160
entire embryonic mesenchyme1.16e-15160
paraxial mesoderm1.20e-1572
presumptive paraxial mesoderm1.20e-1572
somite1.32e-1571
presomitic mesoderm1.32e-1571
presumptive segmental plate1.32e-1571
dermomyotome1.32e-1571
trunk paraxial mesoderm1.32e-1571
blood vessel endothelium2.88e-1318
endothelium2.88e-1318
cardiovascular system endothelium2.88e-1318
trunk mesenchyme1.13e-12122
multilaminar epithelium2.77e-1283
squamous epithelium1.63e-1125
simple squamous epithelium3.81e-1122
aorta8.13e-1121
aortic system8.13e-1121
structure with developmental contribution from neural crest3.27e-10132
organism subdivision1.74e-08264
multi-cellular organism3.14e-08656
anatomical system6.01e-08624
trunk6.30e-08199
anatomical group8.18e-08625
neural plate1.67e-0782
presumptive neural plate1.67e-0782
compound organ1.80e-0768
endothelial tube2.18e-079
arterial system endothelium2.18e-079
endothelium of artery2.18e-079
neurectoderm4.06e-0786


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.14.74396
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.11.30988
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.12.526
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.11.91637
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.01976
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.12.17614
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.10.8309
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.01147
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.10.918944
MA0164.10.90014
MA0080.20.535868
MA0018.23.34398
MA0099.20.7872
MA0079.27.57064
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187936.679850134926750.005184294118278910.0240502151387612
FOS#235348.99795530889440.0001525147711168630.00195034776303099



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.