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Coexpression cluster:C3936

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Full id: C3936_anaplastic_nonsmall_occipital_postcentral_paracentral_frontal_insula



Phase1 CAGE Peaks

Hg19::chr1:211307333..211307357,-p3@KCNH1
Hg19::chr1:211307378..211307389,-p5@KCNH1
Hg19::chr1:211307404..211307472,-p1@KCNH1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
regional part of nervous system4.85e-4094
nervous system4.85e-4094
brain1.11e-3969
future brain1.11e-3969
central nervous system1.33e-3882
neural tube1.37e-3757
neural rod1.37e-3757
future spinal cord1.37e-3757
neural keel1.37e-3757
regional part of brain9.71e-3559
neural plate3.89e-2986
presumptive neural plate3.89e-2986
anterior neural tube2.05e-2842
regional part of forebrain3.66e-2841
forebrain3.66e-2841
future forebrain3.66e-2841
neurectoderm1.53e-2690
telencephalon1.88e-2634
gray matter5.23e-2634
brain grey matter5.23e-2634
regional part of telencephalon1.54e-2533
cerebral hemisphere4.08e-2532
head7.96e-25123
ectoderm-derived structure3.98e-24169
anterior region of body3.98e-24129
craniocervical region3.98e-24129
adult organism4.11e-24115
pre-chordal neural plate2.67e-2361
ectoderm1.12e-22173
presumptive ectoderm1.12e-22173
cerebral cortex6.86e-2025
pallium6.86e-2025
regional part of cerebral cortex7.33e-1922
neocortex2.40e-1720
organism subdivision2.25e-15365
organ part1.61e-11219
posterior neural tube3.83e-1015
chordal neural plate3.83e-1015
segmental subdivision of nervous system1.97e-0913
segmental subdivision of hindbrain1.37e-0812
hindbrain1.37e-0812
presumptive hindbrain1.37e-0812
basal ganglion1.05e-079
nuclear complex of neuraxis1.05e-079
aggregate regional part of brain1.05e-079
collection of basal ganglia1.05e-079
cerebral subcortex1.05e-079
nucleus of brain1.51e-079
neural nucleus1.51e-079
multi-tissue structure2.16e-07347
temporal lobe3.99e-077
organ4.53e-07511
regional part of metencephalon5.18e-079
metencephalon5.18e-079
future metencephalon5.18e-079


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.