Coexpression cluster:C132

Full id: C132_acute_small_Dendritic_Macrophage_CD14_Neutrophils_Monocytederived

Phase1 CAGE Peaks

Hg19::chr10:134258472..134258491,-	p@chr10:134258472..134258491 -
Hg19::chr10:134258649..134258668,+	p1@C10orf91
Hg19::chr10:38446333..38446347,-	p@chr10:38446333..38446347 -
Hg19::chr10:38446358..38446374,-	p@chr10:38446358..38446374 -
Hg19::chr10:65225034..65225046,+	p3@LOC84989
Hg19::chr10:65280689..65280700,+	p29@REEP3
Hg19::chr10:65280796..65280817,+	p13@REEP3
Hg19::chr10:65288352..65288355,+	p@chr10:65288352..65288355 +
Hg19::chr10:90251152..90251159,-	p@chr10:90251152..90251159 -
Hg19::chr11:59949916..59949949,-	p11@MS4A6A
Hg19::chr11:59951230..59951237,-	p15@MS4A6A
Hg19::chr11:59951430..59951444,-	p9@MS4A6A
Hg19::chr11:59951889..59951902,-	p6@MS4A6A
Hg19::chr11:94308189..94308199,+	p@chr11:94308189..94308199 +
Hg19::chr12:117099342..117099357,+	p1@ENST00000546835
Hg19::chr12:24737089..24737109,-	p1@LINC00477
Hg19::chr13:32575640..32575659,+	p@chr13:32575640..32575659 +
Hg19::chr13:46742704..46742715,-	p25@LCP1
Hg19::chr14:21387491..21387506,+	p2@RNASE2
Hg19::chr15:50406680..50406709,-	p7@ATP8B4
Hg19::chr15:75299835..75299854,+	p@chr15:75299835..75299854 +
Hg19::chr16:54304608..54304618,-	p2@ENST00000561336
Hg19::chr16:54304718..54304733,-	p1@ENST00000561336
Hg19::chr16:54304905..54304937,+	p@chr16:54304905..54304937 +
Hg19::chr17:73266490..73266504,-	p11@MIF4GD
Hg19::chr18:22804637..22804660,-	p10@ZNF521
Hg19::chr18:22805268..22805280,-	p8@ZNF521
Hg19::chr18:61568727..61568742,+	p@chr18:61568727..61568742 +
Hg19::chr19:16250693..16250727,-	p1@uc002ndq.1
Hg19::chr19:51226648..51226668,+	p3@CLEC11A
Hg19::chr1:105010966..105010975,-	p@chr1:105010966..105010975 -
Hg19::chr1:105011001..105011012,-	p@chr1:105011001..105011012 -
Hg19::chr1:155151392..155151434,-	p@chr1:155151392..155151434 -
Hg19::chr1:156460402..156460417,-	p22@MEF2D
Hg19::chr1:156460436..156460462,-	p7@MEF2D
Hg19::chr1:156460473..156460486,-	p12@MEF2D
Hg19::chr1:159907468..159907492,+	p@chr1:159907468..159907492 +
Hg19::chr1:173640099..173640102,-	p@chr1:173640099..173640102 -
Hg19::chr1:173640358..173640371,+	p@chr1:173640358..173640371 +
Hg19::chr1:188783243..188783249,+	p@chr1:188783243..188783249 +
Hg19::chr1:189110597..189110603,-	p@chr1:189110597..189110603 -
Hg19::chr1:189110612..189110619,-	p@chr1:189110612..189110619 -
Hg19::chr1:189110647..189110655,-	p@chr1:189110647..189110655 -
Hg19::chr1:189118891..189118896,+	p@chr1:189118891..189118896 +
Hg19::chr1:189279755..189279759,+	p@chr1:189279755..189279759 +
Hg19::chr1:21012873..21012898,-	p10@KIF17
Hg19::chr1:243635289..243635294,+	p@chr1:243635289..243635294 +
Hg19::chr1:246269797..246269820,-	p@chr1:246269797..246269820 -
Hg19::chr1:246271419..246271436,-	p@chr1:246271419..246271436 -
Hg19::chr1:40254482..40254550,-	p1@BMP8B
Hg19::chr1:40265085..40265119,+	p@chr1:40265085..40265119 +
Hg19::chr1:40562908..40562931,-	p1@PPT1
Hg19::chr1:40723846..40723871,+	p2@ZMPSTE24
Hg19::chr1:40723874..40723943,+	p1@ZMPSTE24
Hg19::chr1:40778264..40778280,-	p@chr1:40778264..40778280 -
Hg19::chr1:40778285..40778317,-	p@chr1:40778285..40778317 -
Hg19::chr1:40942922..40942997,+	p1@ZNF642
Hg19::chr1:40974395..40974430,+	p2@DEM1
Hg19::chr1:40974431..40974446,+	p1@DEM1
Hg19::chr1:40974453..40974466,+	p3@DEM1
Hg19::chr1:40997285..40997352,+	p1@ZNF684
Hg19::chr1:40997363..40997392,+	p2@ZNF684
Hg19::chr1:41157363..41157416,+	p1@NFYC
Hg19::chr1:41157421..41157482,+	p2@NFYC
Hg19::chr1:41327085..41327095,-	p@chr1:41327085..41327095 -
Hg19::chr1:44172999..44173025,-	p2@LOC100132774
Hg19::chr1:44265188..44265223,-	p@chr1:44265188..44265223 -
Hg19::chr1:44267074..44267083,+	p@chr1:44267074..44267083 +
Hg19::chr1:44303803..44303811,+	p@chr1:44303803..44303811 +
Hg19::chr1:44303822..44303850,+	p@chr1:44303822..44303850 +
Hg19::chr1:44303858..44303865,+	p@chr1:44303858..44303865 +
Hg19::chr1:82286670..82286676,+	p@chr1:82286670..82286676 +
Hg19::chr20:32810271..32810284,+	p@chr20:32810271..32810284 +
Hg19::chr20:44538665..44538730,-	p4@PLTP
Hg19::chr21:15680790..15680806,+	p@chr21:15680790..15680806 +
Hg19::chr2:121130183..121130188,+	p@chr2:121130183..121130188 +
Hg19::chr2:169939659..169939666,+	p@chr2:169939659..169939666 +
Hg19::chr2:169939683..169939692,+	p@chr2:169939683..169939692 +
Hg19::chr2:169939710..169939721,+	p@chr2:169939710..169939721 +
Hg19::chr2:169939733..169939745,+	p@chr2:169939733..169939745 +
Hg19::chr2:169939776..169939787,+	p@chr2:169939776..169939787 +
Hg19::chr2:169939816..169939834,+	p@chr2:169939816..169939834 +
Hg19::chr2:169939851..169939861,+	p@chr2:169939851..169939861 +
Hg19::chr2:169939862..169939872,+	p@chr2:169939862..169939872 +
Hg19::chr2:169939880..169939894,+	p@chr2:169939880..169939894 +
Hg19::chr2:63282550..63282565,+	p@chr2:63282550..63282565 +
Hg19::chr3:125053819..125053839,-	p@chr3:125053819..125053839 -
Hg19::chr3:18462463..18462475,-	p45@SATB1
Hg19::chr3:26584176..26584198,+	p@chr3:26584176..26584198 +
Hg19::chr3:4562205..4562207,+	p@chr3:4562205..4562207 +
Hg19::chr4:180738607..180738609,-	p@chr4:180738607..180738609 -
Hg19::chr4:180973985..180973992,+	p@chr4:180973985..180973992 +
Hg19::chr4:180980059..180980067,+	p@chr4:180980059..180980067 +
Hg19::chr4:180980085..180980101,+	p@chr4:180980085..180980101 +
Hg19::chr4:181092976..181092979,+	p@chr4:181092976..181092979 +
Hg19::chr4:48198802..48198830,-	p@chr4:48198802..48198830 -
Hg19::chr4:48493343..48493374,-	p@chr4:48493343..48493374 -
Hg19::chr4:62065829..62065850,+	p@chr4:62065829..62065850 +
Hg19::chr5:113697844..113697858,+	p2@KCNN2
Hg19::chr5:113743752..113743764,+	p@chr5:113743752..113743764 +
Hg19::chr5:113743792..113743800,+	p@chr5:113743792..113743800 +
Hg19::chr5:113743823..113743833,+	p@chr5:113743823..113743833 +
Hg19::chr5:113769205..113769213,+	p9@KCNN2
Hg19::chr5:176889489..176889507,-	p20@DBN1
Hg19::chr5:32388629..32388636,-	p14@ZFR
Hg19::chr5:32388639..32388655,-	p8@ZFR
Hg19::chr5:32388671..32388686,-	p10@ZFR
Hg19::chr5:32388687..32388699,-	p9@ZFR
Hg19::chr5:32388710..32388733,-	p5@ZFR
Hg19::chr5:49739173..49739184,-	p8@EMB
Hg19::chr5:59544794..59544804,-	p@chr5:59544794..59544804 -
Hg19::chr5:59544814..59544835,-	p@chr5:59544814..59544835 -
Hg19::chr5:59544841..59544865,-	p@chr5:59544841..59544865 -
Hg19::chr5:72152728..72152735,+	p@chr5:72152728..72152735 +
Hg19::chr6:135516909..135516925,+	p6@MYB
Hg19::chr6:147092283..147092294,-	p@chr6:147092283..147092294 -
Hg19::chr6:170108056..170108066,-	p8@PHF10
Hg19::chr6:170451118..170451126,+	p@chr6:170451118..170451126 +
Hg19::chr6:170478046..170478060,-	p@chr6:170478046..170478060 -
Hg19::chr6:170478075..170478104,-	p@chr6:170478075..170478104 -
Hg19::chr6:38670845..38670895,-	p2@GLO1
Hg19::chr6:76330342..76330351,+	p23@SENP6
Hg19::chr6:76330355..76330365,+	p20@SENP6
Hg19::chr6:79728851..79728869,-	p@chr6:79728851..79728869 -
Hg19::chr6:79729013..79729033,-	p@chr6:79729013..79729033 -
Hg19::chr6:79729149..79729164,-	p@chr6:79729149..79729164 -
Hg19::chr6:79787873..79787890,-	p3@PHIP
Hg19::chr7:11676716..11676733,-	p7@THSD7A
Hg19::chr7:11676734..11676740,-	p26@THSD7A
Hg19::chr8:58333441..58333449,+	p@chr8:58333441..58333449 +
Hg19::chr8:58375259..58375264,+	p@chr8:58375259..58375264 +
Hg19::chr8:58375450..58375469,+	p@chr8:58375450..58375469 +
Hg19::chr8:58375548..58375550,+	p@chr8:58375548..58375550 +
Hg19::chr9:108126806..108126826,+	p@chr9:108126806..108126826 +
Hg19::chr9:211250..211266,+	p@chr9:211250..211266 +
Hg19::chrX:108780604..108780616,+	p@chrX:108780604..108780616 +
Hg19::chrX:113302230..113302241,-	p@chrX:113302230..113302241 -
Hg19::chrX:153524141..153524157,+	p1@TKTL1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050803	regulation of synapse structure and activity	0.0447249954149928

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	1.27e-37	112
common myeloid progenitor	1.27e-37	112
hematopoietic stem cell	1.55e-37	172
angioblastic mesenchymal cell	1.55e-37	172
hematopoietic oligopotent progenitor cell	7.97e-36	165
hematopoietic multipotent progenitor cell	7.97e-36	165
hematopoietic cell	4.64e-34	182
granulocyte monocyte progenitor cell	1.46e-26	71
macrophage dendritic cell progenitor	7.21e-26	65
leukocyte	5.43e-25	140
monopoietic cell	7.33e-25	63
monocyte	7.33e-25	63
monoblast	7.33e-25	63
promonocyte	7.33e-25	63
myeloid lineage restricted progenitor cell	6.21e-24	70
myeloid leukocyte	1.83e-23	76
hematopoietic lineage restricted progenitor cell	1.64e-22	124
nongranular leukocyte	1.87e-22	119
CD14-positive, CD16-negative classical monocyte	2.64e-17	42
classical monocyte	5.00e-17	45

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.45e-27	102
blood island	1.45e-27	102
bone element	7.40e-23	86
bone marrow	7.53e-23	80
hemolymphoid system	1.56e-22	112
adult organism	2.93e-18	115
skeletal element	9.77e-18	101
skeletal system	9.77e-18	101
immune system	2.79e-15	115
regional part of forebrain	1.42e-14	41
forebrain	1.42e-14	41
future forebrain	1.42e-14	41
neural tube	1.47e-14	57
neural rod	1.47e-14	57
future spinal cord	1.47e-14	57
neural keel	1.47e-14	57
anterior neural tube	7.69e-14	42
central nervous system	1.54e-13	82
telencephalon	3.55e-13	34
gray matter	7.38e-13	34
brain grey matter	7.38e-13	34
regional part of telencephalon	8.96e-13	33
cerebral hemisphere	4.57e-12	32
regional part of brain	7.74e-11	59
regional part of nervous system	1.88e-10	94
nervous system	1.88e-10	94
brain	1.94e-10	69
future brain	1.94e-10	69
regional part of cerebral cortex	1.71e-09	22
cerebral cortex	3.02e-09	25
pallium	3.02e-09	25
neocortex	2.29e-08	20
neural plate	3.40e-07	86
presumptive neural plate	3.40e-07	86
neurectoderm	3.69e-07	90

Disease

Ontology term	p-value	n
hematologic cancer	7.01e-18	51
immune system cancer	7.01e-18	51
leukemia	1.45e-16	39
myeloid leukemia	1.61e-14	31
organ system cancer	2.03e-07	137
cancer	7.51e-07	235

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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