Coexpression cluster:C195

Full id: C195_Small_Gingival_Bronchial_Smooth_mesenchymal_Urothelial_Tracheal

Phase1 CAGE Peaks

Hg19::chr10:3941138..3941145,-	p@chr10:3941138..3941145 -
Hg19::chr11:127965642..127965659,+	p@chr11:127965642..127965659 +
Hg19::chr11:127965706..127965714,+	p@chr11:127965706..127965714 +
Hg19::chr11:127965736..127965745,+	p@chr11:127965736..127965745 +
Hg19::chr11:127965839..127965844,+	p@chr11:127965839..127965844 +
Hg19::chr11:127965855..127965866,+	p@chr11:127965855..127965866 +
Hg19::chr11:127965869..127965894,+	p@chr11:127965869..127965894 +
Hg19::chr11:127965904..127965913,+	p@chr11:127965904..127965913 +
Hg19::chr11:127965924..127965935,+	p@chr11:127965924..127965935 +
Hg19::chr11:73663222..73663226,+	p@chr11:73663222..73663226 +
Hg19::chr11:7927293..7927308,-	p4@LOC283299
Hg19::chr11:7927797..7927817,-	p1@LOC283299
Hg19::chr12:10513712..10513716,-	p1@ENST00000535911
Hg19::chr12:28186158..28186183,-	p@chr12:28186158..28186183 -
Hg19::chr14:51963969..51963974,+	p@chr14:51963969..51963974 +
Hg19::chr14:51972517..51972536,+	p@chr14:51972517..51972536 +
Hg19::chr14:52026212..52026215,+	p@chr14:52026212..52026215 +
Hg19::chr14:87730650..87730656,-	p@chr14:87730650..87730656 -
Hg19::chr15:71740021..71740037,+	p@chr15:71740021..71740037 +
Hg19::chr16:85750444..85750466,-	p@chr16:85750444..85750466 -
Hg19::chr17:38653561..38653607,-	p@chr17:38653561..38653607 -
Hg19::chr17:56603082..56603097,+	p@chr17:56603082..56603097 +
Hg19::chr17:56603128..56603137,+	p@chr17:56603128..56603137 +
Hg19::chr17:60858418..60858439,-	p@chr17:60858418..60858439 -
Hg19::chr1:107541218..107541228,-	p@chr1:107541218..107541228 -
Hg19::chr1:209591333..209591335,-	p@chr1:209591333..209591335 -
Hg19::chr1:232854914..232854917,-	p@chr1:232854914..232854917 -
Hg19::chr1:8135925..8135929,-	p@chr1:8135925..8135929 -
Hg19::chr1:94160495..94160512,-	p@chr1:94160495..94160512 -
Hg19::chr21:38233478..38233483,+	p@chr21:38233478..38233483 +
Hg19::chr21:44939980..44939983,+	p@chr21:44939980..44939983 +
Hg19::chr2:163101439..163101452,+	p@chr2:163101439..163101452 +
Hg19::chr2:213770576..213770587,+	p@chr2:213770576..213770587 +
Hg19::chr2:231649545..231649550,-	p@chr2:231649545..231649550 -
Hg19::chr2:56007040..56007060,+	p@chr2:56007040..56007060 +
Hg19::chr2:73299315..73299328,-	p11@SFXN5
Hg19::chr3:101909113..101909129,+	p@chr3:101909113..101909129 +
Hg19::chr3:101909187..101909198,+	p@chr3:101909187..101909198 +
Hg19::chr3:156502182..156502186,+	p@chr3:156502182..156502186 +
Hg19::chr3:189655696..189655699,+	p@chr3:189655696..189655699 +
Hg19::chr3:45476797..45476808,+	p@chr3:45476797..45476808 +
Hg19::chr3:45476828..45476831,+	p@chr3:45476828..45476831 +
Hg19::chr3:45476837..45476843,+	p@chr3:45476837..45476843 +
Hg19::chr3:48602467..48602469,-	p14@COL7A1
Hg19::chr4:108783895..108783898,-	p@chr4:108783895..108783898 -
Hg19::chr4:108909370..108909373,+	p@chr4:108909370..108909373 +
Hg19::chr4:157695866..157695871,+	p@chr4:157695866..157695871 +
Hg19::chr4:166604070..166604073,+	p@chr4:166604070..166604073 +
Hg19::chr5:111445067..111445085,-	p@chr5:111445067..111445085 -
Hg19::chr5:148293809..148293816,+	p@chr5:148293809..148293816 +
Hg19::chr5:52584337..52584344,-	p@chr5:52584337..52584344 -
Hg19::chr5:59064137..59064148,-	p58@PDE4D
Hg19::chr5:59064162..59064173,-	p72@PDE4D
Hg19::chr5:59064199..59064230,-	p28@PDE4D
Hg19::chr6:10355646..10355663,-	p@chr6:10355646..10355663 -
Hg19::chr6:11791877..11791883,+	p@chr6:11791877..11791883 +
Hg19::chr6:12324677..12324683,+	p@chr6:12324677..12324683 +
Hg19::chr6:128922463..128922497,+	p@chr6:128922463..128922497 +
Hg19::chr6:22222867..22222878,-	p@chr6:22222867..22222878 -
Hg19::chr7:106060323..106060328,-	p@chr7:106060323..106060328 -
Hg19::chr7:134328418..134328421,+	p@chr7:134328418..134328421 +
Hg19::chr7:158196067..158196075,-	p@chr7:158196067..158196075 -
Hg19::chr7:55163202..55163244,+	p@chr7:55163202..55163244 +
Hg19::chr7:55263885..55263894,+	p@chr7:55263885..55263894 +
Hg19::chr8:113686674..113686685,-	p@chr8:113686674..113686685 -
Hg19::chr8:113686693..113686717,-	p@chr8:113686693..113686717 -
Hg19::chr8:113686738..113686743,-	p@chr8:113686738..113686743 -
Hg19::chr8:113686752..113686753,-	p@chr8:113686752..113686753 -
Hg19::chr8:113686755..113686782,-	p@chr8:113686755..113686782 -
Hg19::chr8:113686792..113686795,-	p@chr8:113686792..113686795 -
Hg19::chr8:29414184..29414190,+	p@chr8:29414184..29414190 +
Hg19::chr8:29448825..29448836,-	p@chr8:29448825..29448836 -
Hg19::chr8:29449835..29449837,+	p@chr8:29449835..29449837 +
Hg19::chr9:20224892..20224905,-	p@chr9:20224892..20224905 -
Hg19::chr9:21468453..21468457,-	p@chr9:21468453..21468457 -
Hg19::chr9:21499276..21499289,-	p@chr9:21499276..21499289 -
Hg19::chr9:21499446..21499456,-	p@chr9:21499446..21499456 -
Hg19::chr9:21505384..21505411,-	p@chr9:21505384..21505411 -
Hg19::chr9:21543873..21543886,-	p@chr9:21543873..21543886 -
Hg19::chr9:21549553..21549570,-	p@chr9:21549553..21549570 -
Hg19::chr9:21549612..21549619,-	p@chr9:21549612..21549619 -
Hg19::chr9:21559689..21559703,-	p3@MIR31HG
Hg19::chr9:21559717..21559731,-	p4@MIR31HG
Hg19::chr9:21559788..21559806,-	p2@MIR31HG
Hg19::chr9:21559809..21559877,-	p1@MIR31HG
Hg19::chrX:48369279..48369286,+	p9@PORCN
Hg19::chrY:7671916..7671924,-	p@chrY:7671916..7671924 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005590	collagen type VII	0.0114211703756034
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	0.0342514094620916
GO:0030934	anchoring collagen	0.0342514094620916
GO:0005737	cytoplasm	0.0456463678366286
GO:0005626	insoluble fraction	0.0456463678366286

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	8.79e-20	254
embryonic cell	1.02e-19	248
non-terminally differentiated cell	9.12e-15	180
endo-epithelial cell	1.60e-13	43
muscle precursor cell	1.60e-11	57
myoblast	1.60e-11	57
multi-potent skeletal muscle stem cell	1.60e-11	57
muscle cell	1.53e-10	54
contractile cell	4.36e-10	59
smooth muscle cell	9.63e-10	42
smooth muscle myoblast	9.63e-10	42
endodermal cell	1.72e-09	59
vascular associated smooth muscle cell	1.97e-09	32
electrically responsive cell	2.96e-09	60
electrically active cell	2.96e-09	60
animal cell	1.36e-08	679
eukaryotic cell	1.36e-08	679
mesodermal cell	2.52e-08	119
respiratory epithelial cell	2.87e-08	13
squamous epithelial cell	1.69e-07	62
fibroblast	3.29e-07	75

Uber Anatomy

Ontology term	p-value	n
anatomical system	1.44e-17	625
anatomical group	3.64e-17	626
multi-cellular organism	5.10e-17	659
multi-tissue structure	1.34e-15	347
organism subdivision	6.75e-15	365
multilaminar epithelium	2.28e-13	82
epithelium	3.35e-13	309
cell layer	9.36e-13	312
embryonic structure	4.49e-12	605
developing anatomical structure	4.49e-12	605
mesenchyme	4.82e-12	238
entire embryonic mesenchyme	4.82e-12	238
germ layer	5.75e-12	604
embryonic tissue	5.75e-12	604
presumptive structure	5.75e-12	604
epiblast (generic)	5.75e-12	604
embryo	7.41e-12	612
trunk	8.81e-11	216
artery	1.01e-10	42
arterial blood vessel	1.01e-10	42
arterial system	1.01e-10	42
somite	2.01e-10	83
paraxial mesoderm	2.01e-10	83
presomitic mesoderm	2.01e-10	83
presumptive segmental plate	2.01e-10	83
trunk paraxial mesoderm	2.01e-10	83
presumptive paraxial mesoderm	2.01e-10	83
surface structure	2.41e-10	95
trunk mesenchyme	2.45e-10	143
endoderm-derived structure	4.78e-10	169
endoderm	4.78e-10	169
presumptive endoderm	4.78e-10	169
anatomical cluster	5.84e-10	286
muscle tissue	1.12e-09	63
musculature	1.12e-09	63
musculature of body	1.12e-09	63
unilaminar epithelium	1.36e-09	138
systemic artery	1.39e-09	33
systemic arterial system	1.39e-09	33
dermomyotome	1.58e-09	70
skeletal muscle tissue	1.60e-09	61
striated muscle tissue	1.60e-09	61
myotome	1.60e-09	61
anatomical conduit	5.83e-09	241
reproductive structure	1.02e-08	59
reproductive system	1.02e-08	59
female organism	1.10e-08	41
vasculature	1.12e-08	79
vascular system	1.12e-08	79
blood vessel	1.88e-08	60
epithelial tube open at both ends	1.88e-08	60
blood vasculature	1.88e-08	60
vascular cord	1.88e-08	60
splanchnic layer of lateral plate mesoderm	3.21e-08	84
respiratory system	8.62e-08	72
female reproductive organ	9.32e-08	37
female reproductive system	9.32e-08	37
epithelial tube	1.04e-07	118
organ	1.91e-07	511
vessel	2.25e-07	69
reproductive organ	2.37e-07	48
primordium	2.93e-07	168
mesoderm	5.01e-07	448
mesoderm-derived structure	5.01e-07	448
presumptive mesoderm	5.01e-07	448
digestive system	6.05e-07	155
digestive tract	6.05e-07	155
primitive gut	6.05e-07	155
organ part	6.50e-07	219

Disease

Ontology term	p-value	n
female reproductive organ cancer	2.10e-08	27
reproductive organ cancer	4.31e-08	29
ovarian cancer	4.00e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
FOS#2353	28	2.89589366263268	1.2138110998422e-07	6.98838023464274e-06
JUN#3725	21	3.02033808090877	3.74013144524048e-06	0.000122334979019565
NR3C1#2908	15	2.58155574675397	0.000617226990610799	0.00511648302820869
SMARCA4#6597	4	7.2076277382937	0.00241060574578793	0.0135903510652818
STAT3#6774	32	3.86922850470041	6.10156636443326e-12	7.85747829266394e-10

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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