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{{Coexpression_clusters
{
|full_id=C2297_cerebellum_pituitary_insula_putamen_nucleus_parietal_caudate
 

Latest revision as of 12:02, 17 September 2013


Full id: C2297_cerebellum_pituitary_insula_putamen_nucleus_parietal_caudate



Phase1 CAGE Peaks

Hg19::chr14:50159813..50159853,+p1@KLHDC1
Hg19::chr14:50159858..50159893,+p2@KLHDC1
Hg19::chr1:8585945..8586056,-p3@RERE
Hg19::chr6:163148780..163148813,-p1@PARK2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008267poly-glutamine tract binding0.00529848110208407
GO:0006607NLS-bearing substrate import into nucleus0.0344340443057272



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
mature alpha-beta T cell4.73e-0718
alpha-beta T cell4.73e-0718
immature T cell4.73e-0718
mature T cell4.73e-0718
immature alpha-beta T cell4.73e-0718
Uber Anatomy
Ontology termp-valuen
adult organism1.20e-48114
neural tube2.12e-2856
neural rod2.12e-2856
future spinal cord2.12e-2856
neural keel2.12e-2856
regional part of nervous system7.23e-2753
regional part of brain7.23e-2753
brain1.53e-2368
future brain1.53e-2368
nervous system2.22e-2289
central nervous system2.68e-2281
regional part of forebrain6.21e-2241
forebrain6.21e-2241
anterior neural tube6.21e-2241
future forebrain6.21e-2241
neural plate6.18e-2182
presumptive neural plate6.18e-2182
neurectoderm1.57e-2086
telencephalon5.89e-1834
brain grey matter1.08e-1734
gray matter1.08e-1734
cerebral hemisphere9.90e-1732
regional part of telencephalon1.18e-1632
regional part of cerebral cortex1.31e-1422
pre-chordal neural plate2.43e-1461
structure with developmental contribution from neural crest1.58e-13132
neocortex1.84e-1320
ecto-epithelium6.04e-13104
ectoderm-derived structure1.41e-12171
ectoderm1.41e-12171
presumptive ectoderm1.41e-12171
cerebral cortex2.44e-1225
pallium2.44e-1225
posterior neural tube1.21e-0715
chordal neural plate1.21e-0715
organ system subdivision2.88e-07223
basal ganglion4.39e-079
nuclear complex of neuraxis4.39e-079
aggregate regional part of brain4.39e-079
collection of basal ganglia4.39e-079
cerebral subcortex4.39e-079
neural nucleus6.08e-079
nucleus of brain6.08e-079
segmental subdivision of nervous system7.75e-0713


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.10.71247
MA0006.12.26728
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.11.30988
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.18043
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.11.54523
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.11.57689
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.8309
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.777367
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.61785
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.476674
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187645.017155731697390.00157802193473060.00995812887258785
ELF1#199744.258097958807540.003041525565781240.0160690959411487
FOXA2#3170212.31523187633260.009361916285467240.035337351365713
HDAC2#3066310.06171517746970.00156372754474740.0099224825958973
HMGN3#932436.133910792512940.006640696683324720.0282872877440962
PAX5#507935.002174148383370.01196533174786410.0434826292638984
REST#597837.237521537096020.004104697304192610.0195758017148076
SIN3A#2594245.408884726815140.001168172384885160.00795168843805128
TAF1#687243.343046285745290.008005664898701650.0321615431148018
YY1#752844.911170749853860.00171871838055440.0106680868267396
ZNF263#1012736.166381227758010.006539814347975980.0279659202672998



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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