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|ontology_enrichment_disease=
|ontology_enrichment_disease=
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|ontology_enrichment_uberon=UBERON:0007023!4.13e-37!115;UBERON:0001049!3.30e-17!57;UBERON:0005068!3.30e-17!57;UBERON:0006241!3.30e-17!57;UBERON:0007135!3.30e-17!57;UBERON:0002780!2.83e-16!41;UBERON:0001890!2.83e-16!41;UBERON:0006240!2.83e-16!41;UBERON:0003080!5.36e-16!42;UBERON:0002616!6.00e-14!59;UBERON:0001893!1.59e-13!34;UBERON:0000955!1.76e-13!69;UBERON:0006238!1.76e-13!69;UBERON:0002020!2.76e-13!34;UBERON:0003528!2.76e-13!34;UBERON:0001017!3.73e-13!82;UBERON:0002791!4.87e-13!33;UBERON:0001869!1.19e-12!32;UBERON:0000073!6.68e-12!94;UBERON:0001016!6.68e-12!94;UBERON:0005743!7.46e-12!86;UBERON:0002619!3.17e-11!22;UBERON:0001950!2.51e-10!20;UBERON:0000956!1.44e-09!25;UBERON:0000203!1.44e-09!25;UBERON:0002390!1.61e-09!102;UBERON:0003061!1.61e-09!102;UBERON:0002346!3.40e-08!90;UBERON:0002193!4.51e-08!112;UBERON:0003075!9.47e-08!86;UBERON:0007284!9.47e-08!86
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}}
}}

Revision as of 18:51, 8 August 2012


Full id: C3044_Eosinophils_CD4_Neutrophils_CD34_CD8_CD19_Natural



Phase1 CAGE Peaks

Hg19::chr10:74927810..74927834,-p2@ECD
Hg19::chr15:64126110..64126154,-p1@HERC1
Hg19::chr17:47866034..47866060,+p1@KAT7


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0006110regulation of glycolysis0.0153060473107074
GO:0009894regulation of catabolic process0.0407993044316206
GO:0005086ARF guanyl-nucleotide exchange factor activity0.0407993044316206



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.84e-30172
angioblastic mesenchymal cell1.84e-30172
hematopoietic oligopotent progenitor cell3.39e-27165
hematopoietic multipotent progenitor cell3.39e-27165
leukocyte1.25e-26140
hematopoietic cell1.07e-25182
hematopoietic lineage restricted progenitor cell5.10e-20124
nongranular leukocyte4.48e-18119
lymphoid lineage restricted progenitor cell2.10e-1452
lymphocyte3.32e-1453
common lymphoid progenitor3.32e-1453
myeloid cell2.34e-13112
common myeloid progenitor2.34e-13112
mature alpha-beta T cell4.08e-1118
alpha-beta T cell4.08e-1118
immature T cell4.08e-1118
mature T cell4.08e-1118
immature alpha-beta T cell4.08e-1118
myeloid leukocyte2.46e-0976
T cell4.66e-0925
pro-T cell4.66e-0925
CD8-positive, alpha-beta T cell1.49e-0711
granulocyte monocyte progenitor cell5.21e-0771
myeloid lineage restricted progenitor cell6.35e-0770
Uber Anatomy
Ontology termp-valuen
adult organism4.13e-37115
neural tube3.30e-1757
neural rod3.30e-1757
future spinal cord3.30e-1757
neural keel3.30e-1757
regional part of forebrain2.83e-1641
forebrain2.83e-1641
future forebrain2.83e-1641
anterior neural tube5.36e-1642
regional part of brain6.00e-1459
telencephalon1.59e-1334
brain1.76e-1369
future brain1.76e-1369
gray matter2.76e-1334
brain grey matter2.76e-1334
central nervous system3.73e-1382
regional part of telencephalon4.87e-1333
cerebral hemisphere1.19e-1232
regional part of nervous system6.68e-1294
nervous system6.68e-1294
regional part of cerebral cortex3.17e-1122
neocortex2.51e-1020
cerebral cortex1.44e-0925
pallium1.44e-0925
hematopoietic system1.61e-09102
blood island1.61e-09102
neurectoderm3.40e-0890
hemolymphoid system4.51e-08112
neural plate9.47e-0886
presumptive neural plate9.47e-0886


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.