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Coexpression cluster:C2004: Difference between revisions

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|full_id=C2004_Endothelial_mesenchymal_Renal_Smooth_Hepatic_leiomyoma_Preadipocyte
|full_id=C2004_Endothelial_mesenchymal_Renal_Smooth_Hepatic_leiomyoma_Preadipocyte
|id=C2004
|id=C2004
|ontology_enrichment_celltype=CL:0000055!7.87e-29!180;CL:0000222!1.14e-25!119;CL:0000680!5.17e-20!57;CL:0000056!5.17e-20!57;CL:0000355!5.17e-20!57;CL:0000183!8.37e-20!59;CL:0000187!4.71e-19!54;CL:0000192!3.06e-17!42;CL:0000514!3.06e-17!42;CL:0002139!5.34e-16!24;CL:0000393!5.50e-16!60;CL:0000211!5.50e-16!60;CL:0000359!6.24e-15!32;CL:0000115!1.06e-14!35;CL:0000057!1.43e-14!75;CL:0000071!2.63e-12!18;CL:0002546!2.63e-12!18;CL:0002078!4.30e-12!44;CL:0000220!3.69e-08!246;CL:0000213!5.97e-08!57;CL:0000215!5.97e-08!57;CL:0002321!9.14e-08!248;CL:0002494!2.40e-07!16;CL:1000413!7.23e-07!9
|ontology_enrichment_celltype=CL:0000222!2.61e-25!121;CL:0000680!3.38e-19!58;CL:0000056!3.38e-19!58;CL:0000355!3.38e-19!58;CL:0000183!2.15e-18!59;CL:0000187!3.48e-18!55;CL:0000192!1.96e-16!43;CL:0000514!1.96e-16!43;CL:0002139!9.49e-16!24;CL:0000115!3.85e-15!36;CL:0000057!4.69e-15!76;CL:0000393!7.93e-15!61;CL:0000211!7.93e-15!61;CL:0000359!7.95e-15!32;CL:0002078!1.95e-12!45;CL:0000055!4.01e-12!106;CL:0000071!4.14e-12!18;CL:0002546!4.14e-12!18;CL:0002321!6.70e-08!250;CL:0000213!7.75e-08!58;CL:0000215!7.75e-08!58;CL:0002494!5.73e-07!16;CL:1000413!8.18e-07!9
|ontology_enrichment_disease=DOID:2394!7.95e-07!14
|ontology_enrichment_disease=DOID:2394!3.14e-07!14
|ontology_enrichment_uberon=UBERON:0004535!1.47e-38!110;UBERON:0001009!2.23e-38!113;UBERON:0002049!9.27e-33!79;UBERON:0007798!9.27e-33!79;UBERON:0000055!1.70e-30!69;UBERON:0004872!9.16e-30!84;UBERON:0001981!2.80e-27!60;UBERON:0007500!2.80e-27!60;UBERON:0004537!2.80e-27!60;UBERON:0006965!2.80e-27!60;UBERON:0003914!2.09e-25!118;UBERON:0000914!5.59e-23!83;UBERON:0002329!5.59e-23!83;UBERON:0003077!5.59e-23!83;UBERON:0003059!5.59e-23!83;UBERON:0007282!5.59e-23!83;UBERON:0009618!5.59e-23!83;UBERON:0007285!5.59e-23!83;UBERON:0004290!1.66e-22!70;UBERON:0000477!2.37e-21!286;UBERON:0001637!2.82e-20!42;UBERON:0003509!2.82e-20!42;UBERON:0004572!2.82e-20!42;UBERON:0000490!5.32e-20!138;UBERON:0001134!6.89e-20!61;UBERON:0002036!6.89e-20!61;UBERON:0003082!6.89e-20!61;UBERON:0002385!1.27e-19!63;UBERON:0001015!1.27e-19!63;UBERON:0000383!1.27e-19!63;UBERON:0005256!2.06e-19!143;UBERON:0000486!4.70e-17!82;UBERON:0004573!1.09e-15!33;UBERON:0004571!1.09e-15!33;UBERON:0000119!1.24e-15!312;UBERON:0000468!3.18e-15!659;UBERON:0004111!3.44e-15!241;UBERON:0000483!4.46e-15!309;UBERON:0002100!1.05e-14!216;UBERON:0000481!1.49e-14!347;UBERON:0000467!1.49e-13!625;UBERON:0003104!3.20e-13!238;UBERON:0009142!3.20e-13!238;UBERON:0000480!3.21e-13!626;UBERON:0000475!3.60e-13!365;UBERON:0000025!2.08e-12!194;UBERON:0001986!2.63e-12!18;UBERON:0004638!2.63e-12!18;UBERON:0004852!2.63e-12!18;UBERON:0000487!1.88e-11!22;UBERON:0000926!5.43e-11!448;UBERON:0004120!5.43e-11!448;UBERON:0006603!5.43e-11!448;UBERON:0006914!3.30e-10!25;UBERON:0000947!1.47e-09!21;UBERON:0010191!1.47e-09!21;UBERON:0002050!6.49e-09!605;UBERON:0005423!6.49e-09!605;UBERON:0000948!8.23e-09!24;UBERON:0005498!8.23e-09!24;UBERON:0004140!8.23e-09!24;UBERON:0009881!8.23e-09!24;UBERON:0004141!8.23e-09!24;UBERON:0003084!8.23e-09!24;UBERON:0007005!8.23e-09!24;UBERON:0004139!8.23e-09!24;UBERON:0004291!8.23e-09!24;UBERON:0000923!9.30e-09!604;UBERON:0005291!9.30e-09!604;UBERON:0006598!9.30e-09!604;UBERON:0002532!9.30e-09!604;UBERON:0000922!1.12e-08!612;UBERON:0007100!1.37e-08!27;UBERON:0003103!1.24e-07!69;UBERON:0000479!2.06e-07!787;UBERON:0003915!7.23e-07!9;UBERON:0004700!7.23e-07!9;UBERON:0001917!7.23e-07!9
|ontology_enrichment_uberon=UBERON:0004535!4.31e-36!109;UBERON:0001009!7.50e-36!112;UBERON:0002049!9.83e-32!78;UBERON:0007798!9.83e-32!78;UBERON:0000055!1.30e-29!68;UBERON:0004872!2.10e-28!83;UBERON:0007500!2.05e-26!59;UBERON:0001981!2.05e-26!59;UBERON:0004537!2.05e-26!59;UBERON:0006965!2.05e-26!59;UBERON:0003914!1.17e-25!117;UBERON:0007503!5.13e-24!78;UBERON:0000490!1.25e-22!148;UBERON:0002329!3.97e-22!71;UBERON:0003059!3.97e-22!71;UBERON:0007282!3.97e-22!71;UBERON:0004290!3.97e-22!71;UBERON:0009618!3.97e-22!71;UBERON:0007524!7.97e-22!73;UBERON:0003077!8.96e-22!72;UBERON:0007285!8.96e-22!72;UBERON:0001637!5.08e-20!42;UBERON:0003509!5.08e-20!42;UBERON:0004572!5.08e-20!42;UBERON:0001134!3.93e-19!62;UBERON:0002036!3.93e-19!62;UBERON:0003082!3.93e-19!62;UBERON:0002385!7.21e-19!64;UBERON:0001015!7.21e-19!64;UBERON:0000383!7.21e-19!64;UBERON:0003104!2.41e-17!160;UBERON:0009142!2.41e-17!160;UBERON:0005256!3.62e-17!122;UBERON:0000119!4.67e-17!309;UBERON:0000477!1.06e-16!373;UBERON:0000486!1.18e-16!83;UBERON:0000483!1.76e-16!306;UBERON:0004573!1.91e-15!33;UBERON:0004571!1.91e-15!33;UBERON:0004111!3.90e-15!240;UBERON:0000468!1.07e-14!656;UBERON:0000481!1.87e-14!342;UBERON:0000475!2.49e-14!264;UBERON:0002100!3.83e-14!199;UBERON:0000467!3.19e-13!624;UBERON:0000480!6.21e-13!625;UBERON:0000025!1.59e-12!192;UBERON:0004638!4.14e-12!18;UBERON:0001986!4.14e-12!18;UBERON:0004852!4.14e-12!18;UBERON:0000487!2.91e-11!22;UBERON:0000926!4.03e-11!315;UBERON:0004120!4.03e-11!315;UBERON:0006603!4.03e-11!315;UBERON:0006914!9.63e-10!25;UBERON:0000947!1.63e-09!21;UBERON:0010191!1.63e-09!21;UBERON:0000948!1.91e-08!24;UBERON:0005498!1.91e-08!24;UBERON:0004140!1.91e-08!24;UBERON:0009881!1.91e-08!24;UBERON:0004141!1.91e-08!24;UBERON:0003084!1.91e-08!24;UBERON:0007005!1.91e-08!24;UBERON:0004139!1.91e-08!24;UBERON:0004291!1.91e-08!24;UBERON:0007100!3.57e-08!27;UBERON:0003103!8.23e-08!68;UBERON:0000922!1.40e-07!592;UBERON:0005423!3.36e-07!581;UBERON:0003915!8.18e-07!9;UBERON:0004700!8.18e-07!9;UBERON:0001917!8.18e-07!9
|tf_chipseq_enrich=CTCF#10664;4:4.28820509846002:0.00515201558824328:0.0239472765152227!EBF1#1879;4:7.1251734772552:0.000723053104677421:0.00577463815855358!FOS#2353;5:8.9979553088944:1.69470025615156e-05:0.000389937871892956!GATA2#2624;4:10.1959453868432:0.000177544777760982:0.0021583749324385!NR3C1#2908;5:14.973023331173:1.32777388277837e-06:5.26067437570144e-05!RAD21#5885;3:6.2130203372738:0.00775105506881164:0.0318994538492185!REST#5978;4:7.72002297290242:0.000528636377365057:0.00457492994826228!SMARCB1#6598;4:14.6021726249259:4.30486693344344e-05:0.000768934492324097!TFAP2A#7020;5:16.518634373045:8.12390055913032e-07:3.54407706973689e-05!TFAP2C#7022;5:10.8092286098602:6.77323239348459e-06:0.000197539686663819
|tf_chipseq_enrich=CTCF#10664;4:4.28820509846002:0.00515201558824328:0.0239472765152227!EBF1#1879;4:7.1251734772552:0.000723053104677421:0.00577463815855358!FOS#2353;5:8.9979553088944:1.69470025615156e-05:0.000389937871892956!GATA2#2624;4:10.1959453868432:0.000177544777760982:0.0021583749324385!NR3C1#2908;5:14.973023331173:1.32777388277837e-06:5.26067437570144e-05!RAD21#5885;3:6.2130203372738:0.00775105506881164:0.0318994538492185!REST#5978;4:7.72002297290242:0.000528636377365057:0.00457492994826228!SMARCB1#6598;4:14.6021726249259:4.30486693344344e-05:0.000768934492324097!TFAP2A#7020;5:16.518634373045:8.12390055913032e-07:3.54407706973689e-05!TFAP2C#7022;5:10.8092286098602:6.77323239348459e-06:0.000197539686663819
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}}
}}

Revision as of 11:57, 19 October 2012


Full id: C2004_Endothelial_mesenchymal_Renal_Smooth_Hepatic_leiomyoma_Preadipocyte



Phase1 CAGE Peaks

Hg19::chr7:93551017..93551029,+p7@GNG11
Hg19::chr7:93551089..93551142,+p2@GNG11
Hg19::chr7:93551321..93551336,+p6@GNG11
Hg19::chr7:93551356..93551375,+p1@GNG11
Hg19::chr7:93551389..93551406,+p5@GNG11


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
cardiovascular system4.31e-36109
circulatory system7.50e-36112
vasculature9.83e-3278
vascular system9.83e-3278
vessel1.30e-2968
splanchnic layer of lateral plate mesoderm2.10e-2883
epithelial tube open at both ends2.05e-2659
blood vessel2.05e-2659
blood vasculature2.05e-2659
vascular cord2.05e-2659
epithelial tube1.17e-25117
epithelial vesicle5.13e-2478
unilaminar epithelium1.25e-22148
somite3.97e-2271
presomitic mesoderm3.97e-2271
presumptive segmental plate3.97e-2271
dermomyotome3.97e-2271
trunk paraxial mesoderm3.97e-2271
dense mesenchyme tissue7.97e-2273
paraxial mesoderm8.96e-2272
presumptive paraxial mesoderm8.96e-2272
artery5.08e-2042
arterial blood vessel5.08e-2042
arterial system5.08e-2042
skeletal muscle tissue3.93e-1962
striated muscle tissue3.93e-1962
myotome3.93e-1962
muscle tissue7.21e-1964
musculature7.21e-1964
musculature of body7.21e-1964
mesenchyme2.41e-17160
entire embryonic mesenchyme2.41e-17160
trunk mesenchyme3.62e-17122
cell layer4.67e-17309
anatomical cluster1.06e-16373
multilaminar epithelium1.18e-1683
epithelium1.76e-16306
systemic artery1.91e-1533
systemic arterial system1.91e-1533
anatomical conduit3.90e-15240
multi-cellular organism1.07e-14656
multi-tissue structure1.87e-14342
organism subdivision2.49e-14264
trunk3.83e-14199
anatomical system3.19e-13624
anatomical group6.21e-13625
tube1.59e-12192
blood vessel endothelium4.14e-1218
endothelium4.14e-1218
cardiovascular system endothelium4.14e-1218
simple squamous epithelium2.91e-1122
mesoderm4.03e-11315
mesoderm-derived structure4.03e-11315
presumptive mesoderm4.03e-11315
squamous epithelium9.63e-1025
aorta1.63e-0921
aortic system1.63e-0921
heart1.91e-0824
primitive heart tube1.91e-0824
primary heart field1.91e-0824
anterior lateral plate mesoderm1.91e-0824
heart tube1.91e-0824
heart primordium1.91e-0824
cardiac mesoderm1.91e-0824
cardiogenic plate1.91e-0824
heart rudiment1.91e-0824
primary circulatory organ3.57e-0827
compound organ8.23e-0868
embryo1.40e-07592
developing anatomical structure3.36e-07581
endothelial tube8.18e-079
arterial system endothelium8.18e-079
endothelium of artery8.18e-079
Disease
Ontology termp-valuen
ovarian cancer3.14e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066444.288205098460020.005152015588243280.0239472765152227
EBF1#187947.12517347725520.0007230531046774210.00577463815855358
FOS#235358.99795530889441.69470025615156e-050.000389937871892956
GATA2#2624410.19594538684320.0001775447777609820.0021583749324385
NR3C1#2908514.9730233311731.32777388277837e-065.26067437570144e-05
RAD21#588536.21302033727380.007751055068811640.0318994538492185
REST#597847.720022972902420.0005286363773650570.00457492994826228
SMARCB1#6598414.60217262492594.30486693344344e-050.000768934492324097
TFAP2A#7020516.5186343730458.12390055913032e-073.54407706973689e-05
TFAP2C#7022510.80922860986026.77323239348459e-060.000197539686663819



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.