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Coexpression cluster:C1925: Difference between revisions

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|tf_chipseq_enrich=TBP#6908;5:3.70677068709639:0.00142875510672112:0.00919904781399712
|tf_chipseq_enrich=TBP#6908;5:3.70677068709639:0.00142875510672112:0.00919904781399712
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}}
}}

Revision as of 15:11, 26 November 2012


Full id: C1925_heart_adipose_aorta_mucinous_mesenchymal_penis_Chondrocyte



Phase1 CAGE Peaks

Hg19::chr3:21792585..21792625,-p2@ZNF385D
Hg19::chr3:21792631..21792665,-p3@ZNF385D
Hg19::chr3:21792682..21792720,-p1@ZNF385D
Hg19::chr3:21792774..21792789,-p8@ZNF385D
Hg19::chr3:21792790..21792824,-p4@ZNF385D


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
skin fibroblast8.08e-0723
Uber Anatomy
Ontology termp-valuen
adult organism2.70e-38114
structure with developmental contribution from neural crest4.90e-29132
neural plate1.48e-2882
presumptive neural plate1.48e-2882
neurectoderm4.96e-2886
central nervous system1.33e-2681
neural tube2.19e-2556
neural rod2.19e-2556
future spinal cord2.19e-2556
neural keel2.19e-2556
regional part of nervous system2.65e-2453
regional part of brain2.65e-2453
nervous system3.55e-2389
ecto-epithelium7.32e-22104
brain8.77e-2268
future brain8.77e-2268
pre-chordal neural plate1.33e-2061
brain grey matter1.86e-2034
gray matter1.86e-2034
regional part of forebrain2.77e-2041
forebrain2.77e-2041
anterior neural tube2.77e-2041
future forebrain2.77e-2041
telencephalon5.45e-2034
ectoderm-derived structure5.48e-20171
ectoderm5.48e-20171
presumptive ectoderm5.48e-20171
cerebral hemisphere6.26e-2032
regional part of telencephalon3.06e-1932
cerebral cortex1.35e-1625
pallium1.35e-1625
multi-cellular organism1.67e-15656
regional part of cerebral cortex7.92e-1522
neocortex1.39e-1420
anatomical cluster2.28e-14373
anatomical system7.37e-12624
cell layer8.42e-12309
epithelium9.63e-12306
anatomical group1.06e-11625
multi-tissue structure1.16e-11342
organ system subdivision3.50e-10223
organ part1.56e-08218
tissue2.11e-08773
anatomical conduit3.20e-08240
tube7.51e-08192
embryo5.99e-07592


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TBP#690853.706770687096390.001428755106721120.00919904781399712



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.