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Coexpression cluster:C4780

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Full id: C4780_lung_mesothelioma_Neutrophils_pituitary_liver_Adipocyte_merkel



Phase1 CAGE Peaks

Hg19::chr8:93978294..93978307,-p3@C8orf83
Hg19::chr8:93978309..93978331,-p2@C8orf83
Hg19::chr8:93978333..93978345,-p4@C8orf83


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube5.54e-1657
neural rod5.54e-1657
future spinal cord5.54e-1657
neural keel5.54e-1657
regional part of brain1.50e-1559
brain7.03e-1569
future brain7.03e-1569
regional part of forebrain1.38e-1441
forebrain1.38e-1441
future forebrain1.38e-1441
central nervous system2.58e-1482
anterior neural tube2.63e-1442
multi-cellular organism2.93e-14659
organ7.37e-14511
adult organism1.07e-13115
regional part of nervous system1.55e-1394
nervous system1.55e-1394
head4.84e-12123
ectoderm-derived structure7.09e-12169
ectoderm1.16e-11173
presumptive ectoderm1.16e-11173
neural plate2.10e-1186
presumptive neural plate2.10e-1186
gray matter3.45e-1134
brain grey matter3.45e-1134
telencephalon4.73e-1134
neurectoderm5.63e-1190
anatomical system7.79e-11625
organism subdivision8.39e-11365
anterior region of body9.08e-11129
craniocervical region9.08e-11129
regional part of telencephalon1.10e-1033
cerebral hemisphere1.18e-1032
anatomical group1.19e-10626
pre-chordal neural plate2.88e-0961
regional part of cerebral cortex1.91e-0822
embryonic structure4.23e-08605
developing anatomical structure4.23e-08605
embryo5.23e-08612
germ layer6.68e-08604
embryonic tissue6.68e-08604
presumptive structure6.68e-08604
epiblast (generic)6.68e-08604
neocortex1.91e-0720
cerebral cortex2.13e-0725
pallium2.13e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.