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MCL coexpression mm9:1496

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:126602421..126602454,+p3@B4galnt1
Mm9::chr11:3004786..3004802,-p@chr11:3004786..3004802
-
Mm9::chr16:45224438..45224459,+p3@Btla
Mm9::chr16:45224470..45224477,+p@chr16:45224470..45224477
+
Mm9::chr1:140072269..140072281,-p7@Ptprc


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0042100B cell proliferation0.000987627375769529
GO:0002768immune response-regulating cell surface receptor signaling pathway0.000987627375769529
GO:0002764immune response-regulating signal transduction0.000987627375769529
GO:0042129regulation of T cell proliferation0.000987627375769529
GO:0032944regulation of mononuclear cell proliferation0.000987627375769529
GO:0050670regulation of lymphocyte proliferation0.000987627375769529
GO:0042098T cell proliferation0.000987627375769529
GO:0050863regulation of T cell activation0.00113618692507234
GO:0032943mononuclear cell proliferation0.00125657145191464
GO:0046651lymphocyte proliferation0.00125657145191464
GO:0051249regulation of lymphocyte activation0.00130742180675326
GO:0042113B cell activation0.00130742180675326
GO:0050865regulation of cell activation0.00130742180675326
GO:0042110T cell activation0.00229019272800312
GO:0001915negative regulation of T cell mediated cytotoxicity0.00250650800414308
GO:0003947(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity0.00250650800414308
GO:0009897external side of plasma membrane0.00250650800414308
GO:0009986cell surface0.00364831547158889
GO:0046649lymphocyte activation0.00364831547158889
GO:0001960negative regulation of cytokine and chemokine mediated signaling pathway0.00364831547158889
GO:0046642negative regulation of alpha-beta T cell proliferation0.00364831547158889
GO:0045321leukocyte activation0.00364831547158889
GO:0001775cell activation0.00364831547158889
GO:0001916positive regulation of T cell mediated cytotoxicity0.00364831547158889
GO:0051283negative regulation of sequestering of calcium ion0.00364831547158889
GO:0001574ganglioside biosynthetic process0.00364831547158889
GO:0051208sequestering of calcium ion0.00364831547158889
GO:0002711positive regulation of T cell mediated immunity0.00364831547158889
GO:0001959regulation of cytokine and chemokine mediated signaling pathway0.00364831547158889
GO:0001914regulation of T cell mediated cytotoxicity0.00364831547158889
GO:0051238sequestering of metal ion0.00364831547158889
GO:0046636negative regulation of alpha-beta T cell activation0.00364831547158889
GO:0051282regulation of sequestering of calcium ion0.00364831547158889
GO:0050857positive regulation of antigen receptor-mediated signaling pathway0.00364831547158889
GO:0051209release of sequestered calcium ion into cytosol0.00364831547158889
GO:0002709regulation of T cell mediated immunity0.00436526650418391
GO:0001911negative regulation of leukocyte mediated cytotoxicity0.00436526650418391
GO:0030259lipid glycosylation0.00436526650418391
GO:0001913T cell mediated cytotoxicity0.00436526650418391
GO:0051239regulation of multicellular organismal process0.00444467753486734
GO:0006688glycosphingolipid biosynthetic process0.0051901239530375
GO:0042127regulation of cell proliferation0.00549853888593896
GO:0050853B cell receptor signaling pathway0.00692745276002293
GO:0001573ganglioside metabolic process0.00724289717845153
GO:0002456T cell mediated immunity0.00724289717845153
GO:0030889negative regulation of B cell proliferation0.00724289717845153
GO:0009247glycolipid biosynthetic process0.00724289717845153
GO:0046640regulation of alpha-beta T cell proliferation0.00781524904835845
GO:0051607defense response to virus0.00781524904835845
GO:0019915sequestering of lipid0.00834261915458024
GO:0006687glycosphingolipid metabolic process0.00834261915458024
GO:0050854regulation of antigen receptor-mediated signaling pathway0.00866657941083101
GO:0050869negative regulation of B cell activation0.00866657941083101
GO:0046634regulation of alpha-beta T cell activation0.00866657941083101
GO:0008283cell proliferation0.0088796772213343
GO:0046633alpha-beta T cell proliferation0.0089563567987543
GO:0001912positive regulation of leukocyte mediated cytotoxicity0.0089563567987543
GO:0006955immune response0.00897164778533966
GO:0042130negative regulation of T cell proliferation0.00981593102114039
GO:0002705positive regulation of leukocyte mediated immunity0.00981593102114039
GO:0051235maintenance of localization0.00981593102114039
GO:0031341regulation of cell killing0.00981593102114039
GO:0002708positive regulation of lymphocyte mediated immunity0.00981593102114039
GO:0030148sphingolipid biosynthetic process0.00981593102114039
GO:0001910regulation of leukocyte mediated cytotoxicity0.00981593102114039
GO:0002699positive regulation of immune effector process0.0101572226932141
GO:0006664glycolipid metabolic process0.0101572226932141
GO:0007204elevation of cytosolic calcium ion concentration0.0103289666262468
GO:0002703regulation of leukocyte mediated immunity0.0103289666262468
GO:0002706regulation of lymphocyte mediated immunity0.0103289666262468
GO:0002824positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.010344820902777
GO:0050868negative regulation of T cell activation0.010344820902777
GO:0008376acetylgalactosaminyltransferase activity0.010344820902777
GO:0002821positive regulation of adaptive immune response0.010344820902777
GO:0002697regulation of immune effector process0.0103589893539178
GO:0050672negative regulation of lymphocyte proliferation0.0103589893539178
GO:0051480cytosolic calcium ion homeostasis0.0103589893539178
GO:0032945negative regulation of mononuclear cell proliferation0.0103589893539178
GO:0030888regulation of B cell proliferation0.0112701985488289
GO:0001909leukocyte mediated cytotoxicity0.0112701985488289
GO:0001906cell killing0.0112701985488289
GO:0002819regulation of adaptive immune response0.0112701985488289
GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains.0.0112701985488289
GO:0006672ceramide metabolic process0.0115046148733659
GO:0030258lipid modification0.0115046148733659
GO:0030173integral to Golgi membrane0.0119416837886238
GO:0046519sphingoid metabolic process0.0119416837886238
GO:0031228intrinsic to Golgi membrane0.0119416837886238
GO:0051250negative regulation of lymphocyte activation0.0119416837886238
GO:0050851antigen receptor-mediated signaling pathway0.0124750958328535
GO:0005925focal adhesion0.0124750958328535
GO:0042102positive regulation of T cell proliferation0.0124750958328535
GO:0002376immune system process0.0125726643711438
GO:0005924cell-substrate adherens junction0.0138679036118073
GO:0046631alpha-beta T cell activation0.0138679036118073
GO:0002429immune response-activating cell surface receptor signaling pathway0.0141653615311815
GO:0030055cell-matrix junction0.0147069576839938
GO:0030183B cell differentiation0.0147069576839938
GO:0048523negative regulation of cellular process0.0147069576839938
GO:0032946positive regulation of mononuclear cell proliferation0.0147069576839938
GO:0002757immune response-activating signal transduction0.0147069576839938
GO:0006469negative regulation of protein kinase activity0.0147069576839938
GO:0033673negative regulation of kinase activity0.0147069576839938
GO:0050671positive regulation of lymphocyte proliferation0.0147069576839938
GO:0050864regulation of B cell activation0.0149707065010711
GO:0051348negative regulation of transferase activity0.0152294350073338
GO:0048519negative regulation of biological process0.0162830468959154
GO:0006665sphingolipid metabolic process0.0165171969946909
GO:0050870positive regulation of T cell activation0.0167544030354514
GO:0019221cytokine and chemokine mediated signaling pathway0.0173723752787155
GO:0043086negative regulation of catalytic activity0.0179790452016474
GO:0019901protein kinase binding0.0181966375578793
GO:0009615response to virus0.0184103375493916
GO:0019900kinase binding0.0184583324124759
GO:0031301integral to organelle membrane0.0184583324124759
GO:0031300intrinsic to organelle membrane0.020123610986793
GO:0006874cellular calcium ion homeostasis0.0213896047952791
GO:0005912adherens junction0.0213896047952791
GO:0055074calcium ion homeostasis0.0213896047952791
GO:0051251positive regulation of lymphocyte activation0.0213896047952791
GO:0030217T cell differentiation0.0213896047952791
GO:0006875cellular metal ion homeostasis0.0229468613137807
GO:0055065metal ion homeostasis0.0234474349854449
GO:0000139Golgi membrane0.0235990826085657
GO:0016323basolateral plasma membrane0.0237482666926464
GO:0046467membrane lipid biosynthetic process0.0242302665272944
GO:0002253activation of immune response0.0257018337805838
GO:0043413biopolymer glycosylation0.0261605319984295
GO:0008194UDP-glycosyltransferase activity0.028029654037201
GO:0004725protein tyrosine phosphatase activity0.028029654037201
GO:0002250adaptive immune response0.0285632234116239
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0285632234116239
GO:0009968negative regulation of signal transduction0.0286654112364548
GO:0030098lymphocyte differentiation0.0288651420565354
GO:0002449lymphocyte mediated immunity0.0288651420565354
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0295823609825766
GO:0050778positive regulation of immune response0.0296739229998401
GO:0055066di-, tri-valent inorganic cation homeostasis0.0298529945699952
GO:0002684positive regulation of immune system process0.0298529945699952
GO:0002443leukocyte mediated immunity0.0299405620188862
GO:0030003cellular cation homeostasis0.0312210729278844
GO:0006470protein amino acid dephosphorylation0.031593914463362
GO:0055080cation homeostasis0.0316672110673864
GO:0050776regulation of immune response0.0324807880405482
GO:0044459plasma membrane part0.0324807880405482
GO:0002682regulation of immune system process0.0327449710873612
GO:0043412biopolymer modification0.0332728919083019
GO:0051240positive regulation of multicellular organismal process0.0332728919083019
GO:0016311dephosphorylation0.0332728919083019
GO:0008285negative regulation of cell proliferation0.0332728919083019
GO:0002521leukocyte differentiation0.0353220015837589
GO:0045859regulation of protein kinase activity0.0353220015837589
GO:0006917induction of apoptosis0.0354084129998478
GO:0012502induction of programmed cell death0.0354084129998478
GO:0043549regulation of kinase activity0.0356539908169318
GO:0044431Golgi apparatus part0.0356539908169318
GO:0019899enzyme binding0.0356539908169318
GO:0016758transferase activity, transferring hexosyl groups0.0356539908169318
GO:0002252immune effector process0.0356539908169318
GO:0051338regulation of transferase activity0.0356539908169318
GO:0004721phosphoprotein phosphatase activity0.0377760273175131
GO:0006873cellular ion homeostasis0.0378265910635761
GO:0055082cellular chemical homeostasis0.0378265910635761
GO:0006643membrane lipid metabolic process0.0388727940883598
GO:0043065positive regulation of apoptosis0.0416802166691896
GO:0051707response to other organism0.0416810069524464
GO:0043068positive regulation of programmed cell death0.041681760089472
GO:0050801ion homeostasis0.0416824767451136
GO:0008284positive regulation of cell proliferation0.0439078312950332
GO:0016021integral to membrane0.045164041073696
GO:0031224intrinsic to membrane0.045164041073696
GO:0005886plasma membrane0.045164041073696



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
mature alpha-beta T cell6.00e-139
alpha-beta T cell6.00e-139
immature T cell6.00e-139
mature T cell6.00e-139
immature alpha-beta T cell6.00e-139
hematopoietic lineage restricted progenitor cell1.05e-1125
CD4-positive, alpha-beta T cell1.18e-118
lymphoid lineage restricted progenitor cell2.52e-1112
hematopoietic cell4.35e-1132
hematopoietic oligopotent progenitor cell4.35e-1132
hematopoietic stem cell4.35e-1132
angioblastic mesenchymal cell4.35e-1132
hematopoietic multipotent progenitor cell4.35e-1132
lymphocyte3.20e-1013
common lymphoid progenitor3.20e-1013
T cell4.11e-1011
pro-T cell4.11e-1011
thymocyte1.65e-096
double negative thymocyte1.65e-096
naive T cell1.65e-096
double-positive, alpha-beta thymocyte1.65e-096
CD4-positive, alpha-beta thymocyte1.65e-096
naive thymus-derived CD4-positive, alpha-beta T cell1.65e-096
DN4 thymocyte1.65e-096
DN1 thymic pro-T cell1.65e-096
DN2 thymocyte1.65e-096
DN3 thymocyte1.65e-096
immature single positive thymocyte1.65e-096
early T lineage precursor1.65e-096
mature CD4 single-positive thymocyte1.65e-096
resting double-positive thymocyte1.65e-096
double-positive blast1.65e-096
CD69-positive double-positive thymocyte1.65e-096
CD69-positive, CD4-positive single-positive thymocyte1.65e-096
CD4-positive, CD8-intermediate double-positive thymocyte1.65e-096
CD24-positive, CD4 single-positive thymocyte1.65e-096
megakaryocyte progenitor cell1.52e-086
megakaryocyte1.52e-086
nucleate cell9.28e-0816
leukocyte3.88e-0717
nongranular leukocyte3.88e-0717

Uber Anatomy
Ontology termp-valuen
hemolymphoid system9.83e-2648
immune system9.83e-2648
hemopoietic organ1.20e-2229
immune organ1.20e-2229
hematopoietic system1.79e-2245
blood island1.79e-2245
gland of gut9.64e-2024
thymus1.14e-1823
neck1.14e-1823
respiratory system epithelium1.14e-1823
hemolymphoid system gland1.14e-1823
pharyngeal epithelium1.14e-1823
thymic region1.14e-1823
pharyngeal gland1.14e-1823
entire pharyngeal arch endoderm1.14e-1823
thymus primordium1.14e-1823
early pharyngeal endoderm1.14e-1823
pharynx1.28e-1724
upper respiratory tract1.28e-1724
chordate pharynx1.28e-1724
pharyngeal arch system1.28e-1724
pharyngeal region of foregut1.28e-1724
mixed endoderm/mesoderm-derived structure2.27e-1735
foregut4.37e-1580
segment of respiratory tract5.94e-1527
respiratory system4.81e-1442
respiratory tract3.62e-1341
organ segment2.26e-1135
craniocervical region5.77e-1136
digestive system7.54e-11116
digestive tract7.54e-11116
primitive gut7.54e-11116
endoderm-derived structure1.88e-10118
endoderm1.88e-10118
presumptive endoderm1.88e-10118
lateral plate mesoderm8.04e-1087
endo-epithelium8.96e-1069
subdivision of digestive tract1.09e-09114
gut epithelium1.80e-0955
endocrine gland8.90e-0960
gland2.23e-0865
unilaminar epithelium3.04e-0866
anterior region of body3.42e-0843
mesoderm4.63e-07120
mesoderm-derived structure4.63e-07120
presumptive mesoderm4.63e-07120
endocrine system9.70e-0772


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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