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Coexpression cluster:C4704

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Full id: C4704_mesenchymal_Cardiac_Smooth_Hepatocyte_myxofibrosarcoma_bronchial_gastric



Phase1 CAGE Peaks

Hg19::chr7:89783727..89783738,+p3@STEAP1
Hg19::chr7:89783740..89783755,+p2@STEAP1
Hg19::chr7:89783766..89783821,+p1@STEAP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
trunk2.24e-18216
somite4.68e-1883
paraxial mesoderm4.68e-1883
presomitic mesoderm4.68e-1883
presumptive segmental plate4.68e-1883
trunk paraxial mesoderm4.68e-1883
presumptive paraxial mesoderm4.68e-1883
trunk mesenchyme2.27e-16143
mesenchyme2.31e-16238
entire embryonic mesenchyme2.31e-16238
unilaminar epithelium1.94e-15138
organism subdivision2.11e-15365
multilaminar epithelium5.82e-1582
multi-tissue structure1.01e-14347
dermomyotome2.00e-1470
surface structure1.85e-1395
muscle tissue2.11e-1163
musculature2.11e-1163
musculature of body2.11e-1163
skeletal muscle tissue3.35e-1161
striated muscle tissue3.35e-1161
myotome3.35e-1161
epithelial tube4.96e-11118
multi-cellular organism7.50e-11659
splanchnic layer of lateral plate mesoderm8.72e-1184
epithelium4.16e-10309
blood vessel6.84e-1060
epithelial tube open at both ends6.84e-1060
blood vasculature6.84e-1060
vascular cord6.84e-1060
digestive system1.25e-09155
digestive tract1.25e-09155
primitive gut1.25e-09155
artery1.27e-0942
arterial blood vessel1.27e-0942
arterial system1.27e-0942
cell layer1.43e-09312
vessel2.42e-0969
integument3.95e-0945
integumental system3.95e-0945
anatomical cluster6.82e-09286
systemic artery8.04e-0933
systemic arterial system8.04e-0933
endoderm-derived structure1.04e-08169
endoderm1.04e-08169
presumptive endoderm1.04e-08169
anatomical system1.51e-08625
anatomical group2.12e-08626
vasculature2.60e-0879
vascular system2.60e-0879
anatomical conduit3.40e-08241
skin of body1.74e-0740
mesoderm4.49e-07448
mesoderm-derived structure4.49e-07448
presumptive mesoderm4.49e-07448
germ layer6.51e-07604
embryonic tissue6.51e-07604
presumptive structure6.51e-07604
epiblast (generic)6.51e-07604
embryo7.50e-07612
embryonic structure7.87e-07605
developing anatomical structure7.87e-07605


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.