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Coexpression cluster:C2109

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Full id: C2109_spleen_uterus_iPS_thyroid_diaphragm_bile_adipose



Phase1 CAGE Peaks

Hg19::chr11:128457446..128457461,-p4@ETS1
Hg19::chr11:128457478..128457485,-p26@ETS1
Hg19::chr11:128457492..128457506,-p6@ETS1
Hg19::chr1:159172206..159172217,-p3@LOC100131825


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0045648positive regulation of erythrocyte differentiation0.00803602967149417
GO:0045646regulation of erythrocyte differentiation0.00803602967149417
GO:0045639positive regulation of myeloid cell differentiation0.00803602967149417
GO:0030218erythrocyte differentiation0.0126103850229601
GO:0045637regulation of myeloid cell differentiation0.0126103850229601
GO:0045597positive regulation of cell differentiation0.0145266690215472
GO:0051094positive regulation of developmental process0.0178492582126457
GO:0030099myeloid cell differentiation0.0178492582126457
GO:0045595regulation of cell differentiation0.0281261038502296
GO:0030097hemopoiesis0.0281261038502296
GO:0048534hemopoietic or lymphoid organ development0.0281261038502296
GO:0002520immune system development0.0281261038502296
GO:0008285negative regulation of cell proliferation0.031261038502296
GO:0050793regulation of developmental process0.031261038502296



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism4.05e-50115
neural tube5.29e-2057
neural rod5.29e-2057
future spinal cord5.29e-2057
neural keel5.29e-2057
central nervous system3.40e-1882
regional part of nervous system5.39e-1794
nervous system5.39e-1794
brain7.20e-1669
future brain7.20e-1669
regional part of brain1.30e-1559
anatomical conduit7.51e-15241
anterior neural tube1.50e-1442
neural plate4.02e-1486
presumptive neural plate4.02e-1486
neurectoderm5.78e-1490
regional part of forebrain6.87e-1441
forebrain6.87e-1441
future forebrain6.87e-1441
anatomical cluster2.60e-13286
gray matter1.25e-1134
brain grey matter1.25e-1134
tube1.36e-11194
telencephalon1.36e-1134
regional part of telencephalon4.23e-1133
anterior region of body9.08e-11129
craniocervical region9.08e-11129
cerebral hemisphere1.05e-1032
multi-cellular organism1.42e-10659
ectoderm5.25e-10173
presumptive ectoderm5.25e-10173
ectoderm-derived structure6.07e-10169
regional part of cerebral cortex9.37e-1022
cerebral cortex1.01e-0925
pallium1.01e-0925
head1.79e-09123
neocortex9.94e-0920
pre-chordal neural plate1.23e-0861
embryo1.34e-08612
anatomical system2.95e-08625
anatomical group3.67e-08626
male reproductive organ7.22e-0811
epithelium5.45e-07309
cell layer5.70e-07312
posterior neural tube9.82e-0715
chordal neural plate9.82e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.