MCL coexpression mm9:328

Phase1 CAGE Peaks

	Short description
Mm9::chr10:40603275..40603289,+	p5@Wasf1
Mm9::chr10:40603299..40603314,+	p3@Wasf1
Mm9::chr10:40603426..40603440,+	p4@Wasf1
Mm9::chr10:80464083..80464115,-	p3@Gng7
Mm9::chr11:5966357..5966368,-	p14@Camk2b
Mm9::chr11:5966374..5966387,-	p8@Camk2b
Mm9::chr13:55050724..55050747,+	p2@Unc5a
Mm9::chr14:122137717..122137728,-	p15@Dock9
Mm9::chr14:122137765..122137775,-	p16@Dock9
Mm9::chr14:56130053..56130057,-	p@chr14:56130053..56130057 -
Mm9::chr15:37447238..37447243,+	p@chr15:37447238..37447243 +
Mm9::chr16:75447352..75447361,-	p@chr16:75447352..75447361 -
Mm9::chr17:13044761..13044782,-	p1@Mas1
Mm9::chr17:70871052..70871078,+	p13@Dlgap1
Mm9::chr18:74874391..74874406,+	p13@Myo5b
Mm9::chr18:74874419..74874428,+	p18@Myo5b
Mm9::chr18:74874437..74874450,+	p12@Myo5b
Mm9::chr19:28084383..28084396,-	p@chr19:28084383..28084396 -
Mm9::chr4:103292185..103292197,+	p9@Dab1
Mm9::chr5:27588740..27588750,+	p19@Dpp6
Mm9::chr5:27588762..27588776,+	p10@Dpp6
Mm9::chr7:3390657..3390678,+	p@chr7:3390657..3390678 +
Mm9::chr7:3391221..3391241,+	p@chr7:3391221..3391241 +
Mm9::chr7:3391251..3391262,+	p@chr7:3391251..3391262 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0021801	cerebral cortex radial glia guided migration	0.0156138716923246
GO:0021799	cerebral cortex radially oriented cell migration	0.0156138716923246
GO:0021589	cerebellum structural organization	0.0156138716923246
GO:0021813	cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration	0.0156138716923246
GO:0021577	hindbrain structural organization	0.0156138716923246
GO:0048532	organization of an anatomical structure	0.0156138716923246
GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration	0.0156138716923246
GO:0021942	radial glia guided migration of Purkinje cell	0.0156138716923246
GO:0021932	hindbrain radial glia guided cell migration	0.0249760353894974
GO:0007168	receptor guanylyl cyclase signaling pathway	0.0249760353894974
GO:0005516	calmodulin binding	0.0307942104658189
GO:0021535	cell migration in hindbrain	0.0312123473389508
GO:0021795	cerebral cortex cell migration	0.0384057263879851
GO:0042169	SH2 domain binding	0.0415856935171347
GO:0005083	small GTPase regulator activity	0.0415856935171347
GO:0005954	calcium- and calmodulin-dependent protein kinase complex	0.0415856935171347
GO:0021885	forebrain cell migration	0.0415856935171347
GO:0022029	telencephalon cell migration	0.0415856935171347
GO:0004274	dipeptidyl-peptidase IV activity	0.0459518053958278
GO:0021987	cerebral cortex development	0.0498455976785651
GO:0015629	actin cytoskeleton	0.0498455976785651

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	4.05e-12	23
neuroblast (sensu Vertebrata)	4.05e-12	23
neuron	2.36e-07	33
neuronal stem cell	2.36e-07	33
neuroblast	2.36e-07	33
electrically signaling cell	2.36e-07	33

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	2.86e-32	54
gray matter	6.42e-32	34
neural tube	1.64e-31	52
neural rod	1.64e-31	52
future spinal cord	1.64e-31	52
neural keel	1.64e-31	52
neurectoderm	1.60e-28	64
neural plate	1.60e-28	64
presumptive neural plate	1.60e-28	64
central nervous system	4.23e-26	73
brain	3.32e-25	47
future brain	3.32e-25	47
brain grey matter	3.88e-25	29
regional part of telencephalon	3.88e-25	29
telencephalon	3.88e-25	29
nervous system	3.99e-25	75
regional part of brain	7.98e-24	46
ecto-epithelium	9.42e-24	73
anterior neural tube	3.50e-22	40
cerebral cortex	9.24e-22	21
cerebral hemisphere	9.24e-22	21
pallium	9.24e-22	21
pre-chordal neural plate	3.25e-21	49
ectoderm-derived structure	3.96e-21	95
ectoderm	3.96e-21	95
presumptive ectoderm	3.96e-21	95
regional part of forebrain	7.02e-21	39
forebrain	7.02e-21	39
future forebrain	7.02e-21	39
regional part of cerebral cortex	5.11e-19	17
occipital lobe	1.92e-18	10
visual cortex	1.92e-18	10
neocortex	1.92e-18	10
structure with developmental contribution from neural crest	9.00e-17	92
posterior neural tube	1.13e-09	12
chordal neural plate	1.13e-09	12
spinal cord	1.90e-09	6
dorsal region element	1.90e-09	6
dorsum	1.90e-09	6
tube	2.59e-09	114
anatomical conduit	3.94e-08	122
regional part of spinal cord	4.81e-08	5
gray matter of spinal cord	4.81e-08	5

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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