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Coexpression cluster:C4082

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Full id: C4082_caudate_testicular_putamen_nonsmall_globus_nucleus_diencephalon



Phase1 CAGE Peaks

Hg19::chr21:45788894..45788919,+p7@TRPM2
Hg19::chr21:45788947..45788956,+p19@TRPM2
Hg19::chr21:45788974..45788984,+p14@TRPM2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
lung fibroblast3.27e-121
germ line cell4.88e-077
germ cell4.88e-077
Uber Anatomy
Ontology termp-valuen
basal ganglion6.84e-579
nuclear complex of neuraxis6.84e-579
aggregate regional part of brain6.84e-579
collection of basal ganglia6.84e-579
cerebral subcortex6.84e-579
telencephalic nucleus2.40e-547
corpus striatum5.68e-434
striatum5.68e-434
ventral part of telencephalon5.68e-434
future corpus striatum5.68e-434
neural nucleus3.11e-429
nucleus of brain3.11e-429
regional part of forebrain4.30e-3441
forebrain4.30e-3441
anterior neural tube4.30e-3441
future forebrain4.30e-3441
caudate-putamen9.20e-333
dorsal striatum9.20e-333
regional part of nervous system8.35e-3153
regional part of brain8.35e-3153
neural tube4.34e-2956
neural rod4.34e-2956
future spinal cord4.34e-2956
neural keel4.34e-2956
telencephalon1.50e-2834
brain3.40e-2768
future brain3.40e-2768
pre-chordal neural plate1.44e-2661
regional part of telencephalon1.11e-2432
cerebral hemisphere1.11e-2432
brain grey matter3.29e-2334
gray matter3.29e-2334
central nervous system1.26e-2281
neural plate1.26e-2282
presumptive neural plate1.26e-2282
caudate nucleus1.85e-222
future caudate nucleus1.85e-222
globus pallidus2.85e-222
pallidum2.85e-222
neurectoderm1.70e-2186
nervous system3.22e-2089
limbic system2.98e-195
ecto-epithelium1.83e-17104
adult organism1.31e-13114
structure with developmental contribution from neural crest2.36e-13132
putamen4.06e-121
nucleus accumbens5.05e-121
ventral striatum5.05e-121
insula9.61e-121
corpus callosum1.81e-111
central nervous system cell part cluster1.81e-111
axon tract1.81e-111
intercerebral commissure1.81e-111
dorsal telencephalic commissure1.81e-111
brain white matter1.81e-111
brain commissure1.81e-111
white matter1.81e-111
nervous system commissure1.81e-111
cerebral hemisphere white matter1.81e-111
tube4.70e-10192
ectoderm-derived structure1.05e-09171
ectoderm1.05e-09171
presumptive ectoderm1.05e-09171
organ system subdivision1.56e-09223
anatomical conduit1.37e-07240
diencephalon6.78e-077
future diencephalon6.78e-077


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.