MCL coexpression mm9:266
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 0.000174479123922689 |
| GO:0002764 | immune response-regulating signal transduction | 0.000174479123922689 |
| GO:0050856 | regulation of T cell receptor signaling pathway | 0.00101592759965883 |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 0.00116331845102547 |
| GO:0042110 | T cell activation | 0.00215079251463618 |
| GO:0050852 | T cell receptor signaling pathway | 0.0021524670775335 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 0.00421913575959422 |
| GO:0006955 | immune response | 0.00421913575959422 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.00435844641325555 |
| GO:0046649 | lymphocyte activation | 0.00435844641325555 |
| GO:0002757 | immune response-activating signal transduction | 0.00468276709119705 |
| GO:0045321 | leukocyte activation | 0.00468276709119705 |
| GO:0001775 | cell activation | 0.00531614053961693 |
| GO:0042098 | T cell proliferation | 0.00884527374803037 |
| GO:0051239 | regulation of multicellular organismal process | 0.00902402382806831 |
| GO:0001923 | B-1 B cell differentiation | 0.00902402382806831 |
| GO:0002376 | immune system process | 0.00902402382806831 |
| GO:0050863 | regulation of T cell activation | 0.00902402382806831 |
| GO:0032943 | mononuclear cell proliferation | 0.0111916556393603 |
| GO:0046651 | lymphocyte proliferation | 0.0111916556393603 |
| GO:0002253 | activation of immune response | 0.0115352335980385 |
| GO:0051249 | regulation of lymphocyte activation | 0.0119104786328979 |
| GO:0042113 | B cell activation | 0.0119104786328979 |
| GO:0050865 | regulation of cell activation | 0.0119104786328979 |
| GO:0002335 | mature B cell differentiation | 0.0119104786328979 |
| GO:0046642 | negative regulation of alpha-beta T cell proliferation | 0.0119104786328979 |
| GO:0050778 | positive regulation of immune response | 0.0138950261258893 |
| GO:0002684 | positive regulation of immune system process | 0.0139566917593426 |
| GO:0046636 | negative regulation of alpha-beta T cell activation | 0.0160131525846775 |
| GO:0050776 | regulation of immune response | 0.0166602235441313 |
| GO:0002682 | regulation of immune system process | 0.0167007357964178 |
| GO:0051240 | positive regulation of multicellular organismal process | 0.0173270067086378 |
| GO:0050860 | negative regulation of T cell receptor signaling pathway | 0.0221012889037602 |
| GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway | 0.0221012889037602 |
| GO:0046887 | positive regulation of hormone secretion | 0.0221012889037602 |
| GO:0030889 | negative regulation of B cell proliferation | 0.0343515439631739 |
| GO:0046640 | regulation of alpha-beta T cell proliferation | 0.0375907177745593 |
| GO:0051047 | positive regulation of secretion | 0.0397860618734093 |
| GO:0046983 | protein dimerization activity | 0.0397860618734093 |
| GO:0050869 | negative regulation of B cell activation | 0.0414391459733394 |
| GO:0046634 | regulation of alpha-beta T cell activation | 0.0414391459733394 |
| GO:0046633 | alpha-beta T cell proliferation | 0.044117917155906 |
| GO:0009620 | response to fungus | 0.0450123842535574 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0450123842535574 |
| GO:0042130 | negative regulation of T cell proliferation | 0.0450123842535574 |
| GO:0030693 | caspase activity | 0.0450123842535574 |
| GO:0005070 | SH3/SH2 adaptor activity | 0.0450123842535574 |
| GO:0051092 | activation of NF-kappaB transcription factor | 0.0450123842535574 |
| GO:0007595 | lactation | 0.047230386028979 |
| GO:0050789 | regulation of biological process | 0.0472530048063267 |
| GO:0002520 | immune system development | 0.0472530048063267 |
| GO:0005515 | protein binding | 0.0472530048063267 |
| GO:0002237 | response to molecule of bacterial origin | 0.0478425321748572 |
| GO:0048535 | lymph node development | 0.0478425321748572 |
| GO:0050868 | negative regulation of T cell activation | 0.0478425321748572 |
| GO:0021983 | pituitary gland development | 0.0478425321748572 |
| GO:0032813 | tumor necrosis factor receptor superfamily binding | 0.0478425321748572 |
| GO:0005164 | tumor necrosis factor receptor binding | 0.0478425321748572 |
| GO:0050672 | negative regulation of lymphocyte proliferation | 0.0481484067149273 |
| GO:0032945 | negative regulation of mononuclear cell proliferation | 0.0481484067149273 |
| GO:0048518 | positive regulation of biological process | 0.0481484067149273 |
| GO:0021536 | diencephalon development | 0.0481484067149273 |
| GO:0051091 | positive regulation of transcription factor activity | 0.0481484067149273 |
| GO:0046883 | regulation of hormone secretion | 0.0481484067149273 |
| GO:0030888 | regulation of B cell proliferation | 0.0497644230015757 |
| GO:0007154 | cell communication | 0.0498204843844854 |
| GO:0040018 | positive regulation of multicellular organism growth | 0.0498204843844854 |
| GO:0030879 | mammary gland development | 0.0498204843844854 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.717153 |
| MA0004.1 | 0.0806159 |
| MA0006.1 | 0.0229559 |
| MA0007.1 | 0.074003 |
| MA0009.1 | 2.57637 |
| MA0014.1 | 0.396649 |
| MA0017.1 | 0.851794 |
| MA0019.1 | 0.229805 |
| MA0024.1 | 0.332319 |
| MA0025.1 | 0.564682 |
| MA0027.1 | 1.93116 |
| MA0028.1 | 0.262309 |
| MA0029.1 | 0.315482 |
| MA0030.1 | 0.320542 |
| MA0031.1 | 0.293406 |
| MA0038.1 | 0.157421 |
| MA0040.1 | 0.377038 |
| MA0041.1 | 0.0501054 |
| MA0042.1 | 0.0455676 |
| MA0043.1 | 0.446565 |
| MA0046.1 | 0.396073 |
| MA0048.1 | 0.581576 |
| MA0050.1 | 0.669135 |
| MA0051.1 | 0.162867 |
| MA0052.1 | 0.383564 |
| MA0055.1 | 0.297688 |
| MA0056.1 | 0 |
| MA0057.1 | 0.34541 |
| MA0058.1 | 0.043314 |
| MA0059.1 | 0.0474385 |
| MA0060.1 | 0.0454236 |
| MA0061.1 | 1.99806 |
| MA0063.1 | 0 |
| MA0066.1 | 0.4599 |
| MA0067.1 | 0.664516 |
| MA0068.1 | 0.060674 |
| MA0069.1 | 0.383839 |
| MA0070.1 | 0.37599 |
| MA0071.1 | 0.667184 |
| MA0072.1 | 0.369163 |
| MA0073.1 | 0.0140404 |
| MA0074.1 | 0.407556 |
| MA0076.1 | 0.591046 |
| MA0077.1 | 0.351866 |
| MA0078.1 | 0.183594 |
| MA0081.1 | 1.19525 |
| MA0083.1 | 0.445897 |
| MA0084.1 | 0.971934 |
| MA0087.1 | 1.05539 |
| MA0088.1 | 0.811204 |
| MA0089.1 | 0 |
| MA0090.1 | 0.234247 |
| MA0091.1 | 0.0866349 |
| MA0092.1 | 0.0660496 |
| MA0093.1 | 0.0274459 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.123725 |
| MA0101.1 | 1.13442 |
| MA0103.1 | 0.566813 |
| MA0105.1 | 4.00807 |
| MA0106.1 | 0.188607 |
| MA0107.1 | 1.25592 |
| MA0108.2 | 0.687911 |
| MA0109.1 | 0 |
| MA0111.1 | 0.251142 |
| MA0113.1 | 0.508933 |
| MA0114.1 | 1.549 |
| MA0115.1 | 0.448923 |
| MA0116.1 | 0.099038 |
| MA0117.1 | 0.42191 |
| MA0119.1 | 1.6001 |
| MA0122.1 | 0.438479 |
| MA0124.1 | 0.616327 |
| MA0125.1 | 0.55037 |
| MA0130.1 | 0 |
| MA0131.1 | 0.64304 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 2.08616 |
| MA0136.1 | 0.859001 |
| MA0139.1 | 0.0907756 |
| MA0140.1 | 0.390942 |
| MA0141.1 | 0.150112 |
| MA0142.1 | 1.41035 |
| MA0143.1 | 0.180984 |
| MA0144.1 | 0.167901 |
| MA0145.1 | 0.0663158 |
| MA0146.1 | 0.410093 |
| MA0147.1 | 0.0714602 |
| MA0148.1 | 1.034 |
| MA0149.1 | 0.0525422 |
| MA0062.2 | 2.23064 |
| MA0035.2 | 0.397603 |
| MA0039.2 | 2.74137 |
| MA0138.2 | 0.221177 |
| MA0002.2 | 0.202648 |
| MA0137.2 | 0.341252 |
| MA0104.2 | 0.636314 |
| MA0047.2 | 0.924448 |
| MA0112.2 | 0.128205 |
| MA0065.2 | 1.72707 |
| MA0150.1 | 0.0739543 |
| MA0151.1 | 0 |
| MA0152.1 | 0.157023 |
| MA0153.1 | 1.2318 |
| MA0154.1 | 1.04013 |
| MA0155.1 | 0.415044 |
| MA0156.1 | 0.925734 |
| MA0157.1 | 0.259017 |
| MA0158.1 | 0 |
| MA0159.1 | 0.956073 |
| MA0160.1 | 0.089496 |
| MA0161.1 | 0 |
| MA0162.1 | 2.00444 |
| MA0163.1 | 3.71788 |
| MA0164.1 | 0.141659 |
| MA0080.2 | 0.300456 |
| MA0018.2 | 0.883988 |
| MA0099.2 | 0.216863 |
| MA0079.2 | 1.6557 |
| MA0102.2 | 1.0223 |
| MA0258.1 | 0.145079 |
| MA0259.1 | 0.170147 |
| MA0442.1 | 0 |
