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MCL coexpression mm9:503

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:114622071..114622085,-p1@Tph2
Mm9::chr13:73674229..73674258,+p1@Slc6a3
Mm9::chr19:40804786..40804795,-p@chr19:40804786..40804795
-
Mm9::chr1:183734229..183734244,+p@chr1:183734229..183734244
+
Mm9::chr2:144300607..144300618,-p@chr2:144300607..144300618
-
Mm9::chr7:126874249..126874254,+p@chr7:126874249..126874254
+
Mm9::chr7:134085595..134085606,+p6@Kctd13
Mm9::chr7:142460262..142460264,+p1@Nps
Mm9::chr8:74243126..74243137,-p@chr8:74243126..74243137
-
Mm9::chr9:120088834..120088845,+p@chr9:120088834..120088845
+
Mm9::chr9:120088982..120088991,+p@chr9:120088982..120088991
+
Mm9::chr9:120089021..120089032,+p@chr9:120089021..120089032
+
Mm9::chr9:44961019..44961022,+p@chr9:44961019..44961022
+
Mm9::chr9:46721556..46721563,+p5@2900052N01Rik


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0042136neurotransmitter biosynthetic process0.000245733661229158
GO:0042401biogenic amine biosynthetic process0.000396736791075821
GO:0042398amino acid derivative biosynthetic process0.000396736791075821
GO:0042133neurotransmitter metabolic process0.000524086817436587
GO:0009309amine biosynthetic process0.00107626548464798
GO:0006576biogenic amine metabolic process0.00127972276824526
GO:0044271nitrogen compound biosynthetic process0.00127972276824526
GO:0006575amino acid derivative metabolic process0.00133631109211284
GO:0001505regulation of neurotransmitter levels0.00133631109211284
GO:0006725aromatic compound metabolic process0.00198630802753521
GO:0005329dopamine transmembrane transporter activity0.00261476320206392
GO:0007268synaptic transmission0.00383477591649904
GO:0004510tryptophan 5-monooxygenase activity0.00383477591649904
GO:0006587serotonin biosynthetic process from tryptophan0.00383477591649904
GO:0042427serotonin biosynthetic process0.00383477591649904
GO:0019226transmission of nerve impulse0.00454093319721234
GO:0042435indole derivative biosynthetic process0.00454093319721234
GO:0046219indolalkylamine biosynthetic process0.00454093319721234
GO:0015844monoamine transport0.00454093319721234
GO:0042424catecholamine catabolic process0.0050013335388711
GO:0008504monoamine transmembrane transporter activity0.0050013335388711
GO:0042420dopamine catabolic process0.0050013335388711
GO:0042416dopamine biosynthetic process0.0050013335388711
GO:0006519amino acid and derivative metabolic process0.00514984371433935
GO:0060134prepulse inhibition0.00522809391882235
GO:0042428serotonin metabolic process0.00522809391882235
GO:0015872dopamine transport0.00522809391882235
GO:0007267cell-cell signaling0.00522809391882235
GO:0009308amine metabolic process0.00522809391882235
GO:0042069regulation of catecholamine metabolic process0.00522809391882235
GO:0042053regulation of dopamine metabolic process0.00522809391882235
GO:0021984adenohypophysis development0.00522809391882235
GO:0016714oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen0.00522809391882235
GO:0006807nitrogen compound metabolic process0.00559084963740589
GO:0048585negative regulation of response to stimulus0.00559084963740589
GO:0032102negative regulation of response to external stimulus0.00559084963740589
GO:0016597amino acid binding0.00605291905027066
GO:0006568tryptophan metabolic process0.00605291905027066
GO:0032101regulation of response to external stimulus0.00663456693294463
GO:0042135neurotransmitter catabolic process0.0070117596717797
GO:0042423catecholamine biosynthetic process0.0070117596717797
GO:0006586indolalkylamine metabolic process0.00714522281916839
GO:0042434indole derivative metabolic process0.00714522281916839
GO:0042430indole and derivative metabolic process0.00714522281916839
GO:0008324cation transmembrane transporter activity0.00714522281916839
GO:0001964startle response0.00749871236088418
GO:0042402biogenic amine catabolic process0.00838305815551868
GO:0015238drug transporter activity0.00838305815551868
GO:0043176amine binding0.00862210157262331
GO:0007595lactation0.00862210157262331
GO:0042219amino acid derivative catabolic process0.00901608267680635
GO:0021983pituitary gland development0.00975926500261984
GO:0005328neurotransmitter:sodium symporter activity0.00975926500261984
GO:0021536diencephalon development0.0102615942627065
GO:0042417dopamine metabolic process0.0102615942627065
GO:0005326neurotransmitter transporter activity0.0102615942627065
GO:0015075ion transmembrane transporter activity0.0103706484546386
GO:0040018positive regulation of multicellular organism growth0.0108973261830475
GO:0009072aromatic amino acid family metabolic process0.012171436752033
GO:0045927positive regulation of growth0.0124466403825088
GO:0022891substrate-specific transmembrane transporter activity0.0128093772529445
GO:0018958phenol metabolic process0.0132195317952135
GO:0006584catecholamine metabolic process0.0132195317952135
GO:0005275amine transmembrane transporter activity0.0152524120061469
GO:0005887integral to plasma membrane0.0153533224358322
GO:0031226intrinsic to plasma membrane0.0153533224358322
GO:0042446hormone biosynthetic process0.0153533224358322
GO:0022857transmembrane transporter activity0.0153533224358322
GO:0044249cellular biosynthetic process0.0156394999726839
GO:0015370solute:sodium symporter activity0.0164005598667272
GO:0022892substrate-specific transporter activity0.0175356412586621
GO:0048583regulation of response to stimulus0.0175356412586621
GO:0050905neuromuscular process0.0183605712295719
GO:0006836neurotransmitter transport0.0183605712295719
GO:0035270endocrine system development0.0183605712295719
GO:0015294solute:cation symporter activity0.019369730084487
GO:0040014regulation of multicellular organism growth0.019369730084487
GO:0015837amine transport0.0194880506720306
GO:0008076voltage-gated potassium channel complex0.0196033360204182
GO:0044270nitrogen compound catabolic process0.0198252506733136
GO:0009310amine catabolic process0.0198252506733136
GO:0035264multicellular organism growth0.0213261550776926
GO:0046483heterocycle metabolic process0.022789946925116
GO:0009058biosynthetic process0.0232665618871751
GO:0048609reproductive process in a multicellular organism0.0236547437368107
GO:0032504multicellular organism reproduction0.0236547437368107
GO:0048732gland development0.0243668471794751
GO:0042445hormone metabolic process0.0263586050610545
GO:0005249voltage-gated potassium channel activity0.0267030274387872
GO:0030900forebrain development0.0317851837882304
GO:0044459plasma membrane part0.0349696633938186
GO:0022843voltage-gated cation channel activity0.0360376064106183
GO:0005267potassium channel activity0.0374817260078045
GO:0004497monooxygenase activity0.0375887222634755
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0375887222634755
GO:0015293symporter activity0.0395604078330576
GO:0040008regulation of growth0.0431677574714076
GO:0050877neurological system process0.0431677574714076
GO:0006813potassium ion transport0.0440818140889795
GO:0022832voltage-gated channel activity0.0471263956989121
GO:0005244voltage-gated ion channel activity0.0471263956989121
GO:0042802identical protein binding0.0478395716640774
GO:0003008system process0.0478395716640774
GO:0015291secondary active transmembrane transporter activity0.0482096120638034
GO:0007420brain development0.0495169241756483
GO:0005886plasma membrane0.0495169241756483



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
raphe nuclei neuron4.53e-153
neuron of the substantia nigra6.22e-153
CNS neuron (sensu Vertebrata)2.81e-0923
neuroblast (sensu Vertebrata)2.81e-0923

Uber Anatomy
Ontology termp-valuen
regional part of midbrain3.62e-194
midbrain3.62e-194
presumptive midbrain3.62e-194
midbrain neural tube3.62e-194
regional part of nervous system1.45e-1654
raphe nuclei4.53e-153
reticular formation4.53e-153
substantia nigra6.22e-153
telencephalic nucleus6.22e-153
midbrain nucleus6.22e-153
neural nucleus6.22e-153
nucleus of brain6.22e-153
central nervous system2.07e-1373
nervous system5.54e-1375
neural tube1.86e-1252
neural rod1.86e-1252
future spinal cord1.86e-1252
neural keel1.86e-1252
regional part of brain3.86e-1046
medulla oblongata4.20e-102
brainstem4.20e-102
myelencephalon4.20e-102
future myelencephalon4.20e-102
brain6.91e-1047
future brain6.91e-1047
neurectoderm1.01e-0964
neural plate1.01e-0964
presumptive neural plate1.01e-0964
ectoderm-derived structure1.08e-0995
ectoderm1.08e-0995
presumptive ectoderm1.08e-0995
basal ganglion1.65e-098
nuclear complex of neuraxis1.65e-098
aggregate regional part of brain1.65e-098
collection of basal ganglia1.65e-098
cerebral subcortex1.65e-098
posterior neural tube5.09e-0912
chordal neural plate5.09e-0912
ecto-epithelium2.95e-0873
segmental subdivision of hindbrain3.39e-076
segmental subdivision of nervous system3.39e-076
hindbrain3.39e-076
presumptive hindbrain3.39e-076


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0100854
MA0004.10.258473
MA0006.10.1319
MA0007.10.246385
MA0009.10.649874
MA0014.10.023905
MA0017.10.150118
MA0019.10.480432
MA0024.10.608636
MA0025.13.35279
MA0027.12.275
MA0028.10.138956
MA0029.10.588275
MA0030.10.594419
MA0031.10.561217
MA0038.10.381016
MA0040.10.661716
MA0041.12.43453
MA0042.11.05492
MA0043.11.75687
MA0046.10.683926
MA0048.10.289404
MA0050.10.290354
MA0051.10.388883
MA0052.10.669354
MA0055.10.45021
MA0056.10
MA0057.10.107353
MA0058.10.541281
MA0059.10.563468
MA0060.10.0819399
MA0061.10.32765
MA0063.10
MA0066.11.72598
MA0067.10.981551
MA0068.10.0266408
MA0069.10.669676
MA0070.10.660488
MA0071.10.788348
MA0072.11.57103
MA0073.10.00514659
MA0074.10.340281
MA0076.10.163664
MA0077.10.632005
MA0078.11.8866
MA0081.10.210747
MA0083.10.741151
MA0084.11.30392
MA0087.10.699999
MA0088.10.0649199
MA0089.10
MA0090.10.231074
MA0091.10.269175
MA0092.10.231323
MA0093.10.444403
MA0095.10
MA0098.10
MA0100.10.330364
MA0101.10.57968
MA0103.10.157724
MA0105.10.0444807
MA0106.10.425111
MA0107.10.46624
MA0108.20.50131
MA0109.10
MA0111.10.242308
MA0113.10.400008
MA0114.10.0981613
MA0115.10.744589
MA0116.10.8172
MA0117.10.713754
MA0119.10.200349
MA0122.10.732707
MA0124.10.929684
MA0125.10.857794
MA0130.10
MA0131.10.476296
MA0132.10
MA0133.10
MA0135.10.77683
MA0136.10.357464
MA0139.10.499924
MA0140.10.330266
MA0141.10.171891
MA0142.11.35096
MA0143.10.414534
MA0144.10.100037
MA0145.10.189432
MA0146.10.0343188
MA0147.10.107632
MA0148.10.271704
MA0149.10.204102
MA0062.20.046824
MA0035.20.33429
MA0039.20.000784583
MA0138.20.469076
MA0002.20.235791
MA0137.20.506794
MA0104.20.0740839
MA0047.20.380343
MA0112.20.0731504
MA0065.20.0735294
MA0150.10.688872
MA0151.10
MA0152.10.380437
MA0153.10.792819
MA0154.10.118426
MA0155.10.0879017
MA0156.10.163042
MA0157.10.518122
MA0158.10
MA0159.10.114033
MA0160.10.274172
MA0161.10
MA0162.10.0134677
MA0163.10.0388292
MA0164.10.940888
MA0080.20.467794
MA0018.20.959515
MA0099.20.463355
MA0079.23.37562e-09
MA0102.21.35579
MA0258.10.626814
MA0259.10.101001
MA0442.10
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