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Coexpression cluster:C1102

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Full id: C1102_acute_chronic_leukemia_Reticulocytes_dura_bone_Fibroblast



Phase1 CAGE Peaks

Hg19::chr10:103874747..103874767,-p2@LDB1
Hg19::chr17:80708546..80708558,+p@chr17:80708546..80708558
+
Hg19::chr1:65991026..65991079,+p3@LEPR
Hg19::chr22:38539372..38539395,-p4@PLA2G6
Hg19::chr22:50524113..50524135,-p10@MLC1
Hg19::chr2:220379329..220379352,+p3@ACCN4
Hg19::chr6:6710742..6710752,+p@chr6:6710742..6710752
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0045647negative regulation of erythrocyte differentiation0.0444300545866719
GO:0015081sodium ion transmembrane transporter activity0.0444300545866719
GO:0030274LIM domain binding0.0444300545866719
GO:0000299integral to membrane of membrane fraction0.0444300545866719
GO:0045646regulation of erythrocyte differentiation0.0488644285335995



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
regional part of nervous system4.79e-2953
regional part of brain4.79e-2953
neural tube3.43e-2756
neural rod3.43e-2756
future spinal cord3.43e-2756
neural keel3.43e-2756
regional part of forebrain1.84e-2641
forebrain1.84e-2641
anterior neural tube1.84e-2641
future forebrain1.84e-2641
brain3.24e-2568
future brain3.24e-2568
central nervous system3.87e-2481
telencephalon2.65e-2334
brain grey matter4.07e-2334
gray matter4.07e-2334
nervous system6.20e-2389
regional part of telencephalon4.51e-1932
cerebral hemisphere4.71e-1932
neural plate1.90e-1882
presumptive neural plate1.90e-1882
adult organism1.92e-18114
pre-chordal neural plate3.37e-1861
neurectoderm2.59e-1786
neocortex6.18e-1720
regional part of cerebral cortex2.93e-1522
ecto-epithelium2.70e-13104
cerebral cortex3.12e-1325
pallium3.12e-1325
neural nucleus1.38e-129
nucleus of brain1.38e-129
structure with developmental contribution from neural crest3.03e-10132
basal ganglion3.67e-099
nuclear complex of neuraxis3.67e-099
aggregate regional part of brain3.67e-099
collection of basal ganglia3.67e-099
cerebral subcortex3.67e-099
gyrus4.76e-096
ectoderm-derived structure7.85e-09171
ectoderm7.85e-09171
presumptive ectoderm7.85e-09171
organ system subdivision7.54e-08223
telencephalic nucleus9.74e-087
locus ceruleus2.14e-072
brainstem nucleus2.14e-072
hindbrain nucleus2.14e-072
Disease
Ontology termp-valuen
myeloid leukemia4.85e-2031
leukemia3.29e-1539
chronic leukemia1.61e-118
hematologic cancer7.88e-1151
immune system cancer7.88e-1151


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.04589
MA0004.10.502801
MA0006.10.904424
MA0007.10.483857
MA0009.10.973289
MA0014.10.367415
MA0017.10.991615
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.10.48922
MA0043.10.973609
MA0046.10.962263
MA0048.11.25271
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.13.04735
MA0056.10
MA0057.10.369442
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.11.09187
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.10.488375
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.215865
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.538456
MA0089.10
MA0090.10.436918
MA0091.11.26109
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.10.347695
MA0103.10.332048
MA0105.12.29445
MA0106.10.648997
MA0107.10.752965
MA0108.20.806528
MA0109.10
MA0111.10.45062
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.11.78583
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.12.37413
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.10.254954
MA0145.10.0807715
MA0146.10.162729
MA0147.10.281049
MA0148.10.528066
MA0149.12.34207
MA0062.20.563664
MA0035.21.38583
MA0039.20.403603
MA0138.20.704862
MA0002.21.15032
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.21.41281
MA0065.20.591589
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.102476
MA0155.10.910701
MA0156.10.959643
MA0157.10.749547
MA0158.10
MA0159.10.281681
MA0160.10.543522
MA0161.10
MA0162.10.106355
MA0163.11.72058
MA0164.10.678332
MA0080.20.344472
MA0018.20.650405
MA0099.20.572
MA0079.20.770733
MA0102.21.51913
MA0258.10.245543
MA0259.10.787775
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA1#262359.685934388428894.03236593682386e-050.00073857640490345
ZNF263#1012744.698195221148960.00564122953609810.0254806838301423



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.