Coexpression cluster:C2297

Full id: C2297_cerebellum_pituitary_insula_putamen_nucleus_parietal_caudate

Phase1 CAGE Peaks

Hg19::chr14:50159813..50159853,+	p1@KLHDC1
Hg19::chr14:50159858..50159893,+	p2@KLHDC1
Hg19::chr1:8585945..8586056,-	p3@RERE
Hg19::chr6:163148780..163148813,-	p1@PARK2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008267	poly-glutamine tract binding	0.00529848110208407
GO:0006607	NLS-bearing substrate import into nucleus	0.0344340443057272

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
mature alpha-beta T cell	4.73e-07	18
alpha-beta T cell	4.73e-07	18
immature T cell	4.73e-07	18
mature T cell	4.73e-07	18
immature alpha-beta T cell	4.73e-07	18

Uber Anatomy

Ontology term	p-value	n
adult organism	1.20e-48	114
neural tube	2.12e-28	56
neural rod	2.12e-28	56
future spinal cord	2.12e-28	56
neural keel	2.12e-28	56
regional part of nervous system	7.23e-27	53
regional part of brain	7.23e-27	53
brain	1.53e-23	68
future brain	1.53e-23	68
nervous system	2.22e-22	89
central nervous system	2.68e-22	81
regional part of forebrain	6.21e-22	41
forebrain	6.21e-22	41
anterior neural tube	6.21e-22	41
future forebrain	6.21e-22	41
neural plate	6.18e-21	82
presumptive neural plate	6.18e-21	82
neurectoderm	1.57e-20	86
telencephalon	5.89e-18	34
brain grey matter	1.08e-17	34
gray matter	1.08e-17	34
cerebral hemisphere	9.90e-17	32
regional part of telencephalon	1.18e-16	32
regional part of cerebral cortex	1.31e-14	22
pre-chordal neural plate	2.43e-14	61
structure with developmental contribution from neural crest	1.58e-13	132
neocortex	1.84e-13	20
ecto-epithelium	6.04e-13	104
ectoderm-derived structure	1.41e-12	171
ectoderm	1.41e-12	171
presumptive ectoderm	1.41e-12	171
cerebral cortex	2.44e-12	25
pallium	2.44e-12	25
posterior neural tube	1.21e-07	15
chordal neural plate	1.21e-07	15
organ system subdivision	2.88e-07	223
basal ganglion	4.39e-07	9
nuclear complex of neuraxis	4.39e-07	9
aggregate regional part of brain	4.39e-07	9
collection of basal ganglia	4.39e-07	9
cerebral subcortex	4.39e-07	9
neural nucleus	6.08e-07	9
nucleus of brain	6.08e-07	9
segmental subdivision of nervous system	7.75e-07	13

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F6#1876	4	5.01715573169739	0.0015780219347306	0.00995812887258785
ELF1#1997	4	4.25809795880754	0.00304152556578124	0.0160690959411487
FOXA2#3170	2	12.3152318763326	0.00936191628546724	0.035337351365713
HDAC2#3066	3	10.0617151774697	0.0015637275447474	0.0099224825958973
HMGN3#9324	3	6.13391079251294	0.00664069668332472	0.0282872877440962
PAX5#5079	3	5.00217414838337	0.0119653317478641	0.0434826292638984
REST#5978	3	7.23752153709602	0.00410469730419261	0.0195758017148076
SIN3A#25942	4	5.40888472681514	0.00116817238488516	0.00795168843805128
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0321615431148018
YY1#7528	4	4.91117074985386	0.0017187183805544	0.0106680868267396
ZNF263#10127	3	6.16638122775801	0.00653981434797598	0.0279659202672998

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.