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Coexpression cluster:C2719

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Full id: C2719_CD14_CD34_immature_CD133_acute_Macrophage_pharyngeal



Phase1 CAGE Peaks

Hg19::chr3:130569347..130569360,+p13@ATP2C1
Hg19::chr3:130569381..130569392,+p15@ATP2C1
Hg19::chr3:130569523..130569576,+p8@ATP2C1
Hg19::chr3:130569592..130569620,+p5@ATP2C1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism6.12e-23115
hematopoietic system7.94e-22102
blood island7.94e-22102
bone marrow8.79e-2280
hemolymphoid system3.43e-18112
bone element3.72e-1886
neural tube1.16e-1757
neural rod1.16e-1757
future spinal cord1.16e-1757
neural keel1.16e-1757
skeletal element6.19e-15101
skeletal system6.19e-15101
anterior neural tube1.72e-1442
regional part of forebrain3.15e-1441
forebrain3.15e-1441
future forebrain3.15e-1441
regional part of brain4.22e-1359
brain1.11e-1269
future brain1.11e-1269
gray matter2.30e-1234
brain grey matter2.30e-1234
telencephalon2.49e-1234
immune system2.55e-12115
central nervous system3.24e-1282
regional part of telencephalon5.64e-1233
cerebral hemisphere2.53e-1132
neural plate9.28e-1186
presumptive neural plate9.28e-1186
regional part of nervous system1.93e-0994
nervous system1.93e-0994
neurectoderm2.49e-0990
regional part of cerebral cortex9.15e-0922
cerebral cortex1.63e-0825
pallium1.63e-0825
neocortex1.22e-0720
pre-chordal neural plate1.62e-0761
anterior region of body7.11e-07129
craniocervical region7.11e-07129
Disease
Ontology termp-valuen
leukemia7.35e-0839
myeloid leukemia7.51e-0831
hematologic cancer8.64e-0751
immune system cancer8.64e-0751


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.0360246159307874
BCL11A#53335214.18472755180350.007108328585298740.0296290999808435
CHD2#110637.758017125587640.003351522464536340.0173042146862622
EBF1#187948.9064668465690.00015887907472010.00199893647568878
EP300#203335.08045629466740.01144298405398240.0419095880072193
GATA1#2623413.56030814380042.95627390049268e-050.000614795479676533
GATA2#2624412.7449317335543.78864877853583e-050.000722972208626903
IRF1#365935.727872815172930.008097114790333330.0320153922763543
JUNB#3726322.95797449486590.0001359772504018780.00177961504445135
MAFK#7975320.32554985337240.0001953213688931110.00235121812423094
MEF2A#4205418.74323090964418.0978922767748e-060.000224511752453964
MEF2C#4208441.31135449262413.42889182145094e-071.69881419801003e-05
NFKB1#479045.488063424193840.001102199566301980.00768698634424122
PAX5#507935.002174148383370.01196533174786410.0435129107007617
POU2F2#545249.106124057742520.000145395665174930.00188516174738727
REST#597837.237521537096020.004104697304192610.0195874294870041
SP1#666745.69838137814090.0009482606065333980.006851289483621
SPI1#668848.204323508522730.000220661881527680.0024968262453813
STAT2#6773348.94782838983051.42094046481278e-050.000340448729535631
STAT3#677437.889598747865680.003190760481680130.0167431961988741
TAF1#687243.343046285745290.008005664898701650.032284486692235
TAL1#6886322.40146250808020.0001462756395930170.00188930021314063
TBP#690843.706770687096390.005296377814784350.0244701792788437
TRIM28#10155418.59052504526258.36730015875654e-060.000230634062095639



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.