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Coexpression cluster:C3095

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Full id: C3095_Endothelial_mature_Renal_aorta_Hepatic_melanoma_gall



Phase1 CAGE Peaks

Hg19::chr11:119187829..119187847,-p1@MCAM
Hg19::chr17:1395929..1395942,-p8@MYO1C
Hg19::chr17:1395954..1396027,-p3@MYO1C


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0016461unconventional myosin complex0.00865202040666745
GO:0016328lateral plasma membrane0.00865202040666745
GO:0031941filamentous actin0.00865202040666745
GO:0045178basal part of cell0.00865202040666745
GO:0009925basal plasma membrane0.00865202040666745
GO:0005902microvillus0.00865202040666745
GO:0005884actin filament0.0102989628262972
GO:0044459plasma membrane part0.0272109751028391
GO:0016323basolateral plasma membrane0.0272109751028391
GO:0016459myosin complex0.0308184393693123
GO:0005516calmodulin binding0.0369007816345632



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
anatomical cluster4.92e-26373
epithelium3.21e-20306
anatomical conduit5.13e-20240
cell layer6.58e-20309
multi-tissue structure4.52e-18342
tube2.00e-17192
multi-cellular organism2.20e-16656
adult organism1.24e-15114
organ part7.61e-15218
epithelial tube1.06e-13117
blood vessel endothelium1.30e-1318
endothelium1.30e-1318
cardiovascular system endothelium1.30e-1318
anatomical group1.18e-12625
anatomical system1.19e-12624
simple squamous epithelium3.10e-1122
compound organ4.36e-1168
embryo6.39e-11592
subdivision of trunk6.76e-11112
developing anatomical structure1.04e-10581
excretory tube1.55e-1016
kidney epithelium1.55e-1016
abdominal segment of trunk2.37e-1060
abdomen2.37e-1060
organism subdivision4.52e-10264
parenchyma4.58e-1015
nephron epithelium4.67e-1015
renal tubule4.67e-1015
nephron tubule4.67e-1015
nephron4.67e-1015
uriniferous tubule4.67e-1015
nephrogenic mesenchyme4.67e-1015
squamous epithelium8.15e-1025
vasculature3.55e-0978
vascular system3.55e-0978
abdomen element6.46e-0954
abdominal segment element6.46e-0954
renal system1.08e-0848
cavitated compound organ1.10e-0831
vessel1.75e-0868
cortex of kidney2.84e-0812
renal parenchyma2.84e-0812
urinary system structure3.05e-0847
embryonic structure3.63e-08564
kidney4.27e-0826
kidney mesenchyme4.27e-0826
upper urinary tract4.27e-0826
kidney rudiment4.27e-0826
kidney field4.27e-0826
endothelial tube6.80e-089
arterial system endothelium6.80e-089
endothelium of artery6.80e-089
trunk region element8.72e-08101
germ layer8.79e-08560
germ layer / neural crest8.79e-08560
embryonic tissue8.79e-08560
presumptive structure8.79e-08560
germ layer / neural crest derived structure8.79e-08560
epiblast (generic)8.79e-08560
neural plate1.33e-0782
presumptive neural plate1.33e-0782
trunk2.83e-07199
cortex3.14e-0715
structure with developmental contribution from neural crest3.21e-07132
primordium3.24e-07160
splanchnic layer of lateral plate mesoderm4.02e-0783
mesenchyme6.07e-07160
entire embryonic mesenchyme6.07e-07160
ecto-epithelium7.26e-07104
nephron tubule epithelium8.90e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.