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Coexpression cluster:C3449

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Full id: C3449_Eosinophils_CD14_Neutrophils_CD34_granulocyte_Basophils_Mast



Phase1 CAGE Peaks

  Short description
Hg19::chr14:74225423..74225445,+ p1@MIR4505
Hg19::chr14:74226747..74226779,- p3@C14orf43
Hg19::chr14:74226783..74226819,- p4@C14orf43


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
bone marrow2.53e-1976
skeletal element1.18e-1690
bone element1.28e-1682
skeletal system5.15e-16100
hematopoietic system4.96e-1598
blood island4.96e-1598
hemolymphoid system4.22e-13108
immune system1.12e-1293
musculoskeletal system1.17e-12167
anatomical system1.20e-09624
anatomical group1.98e-09625
organ1.04e-08503
lateral plate mesoderm6.64e-08203
multi-cellular organism5.28e-07656
mesoderm8.25e-07315
mesoderm-derived structure8.25e-07315
presumptive mesoderm8.25e-07315


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.13.71555
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.333427
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.407479
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.12.96495
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.11.55117
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.11.70974
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.21.55139
MA0018.20.987913
MA0099.20.902716
MA0079.20.941469
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELF1#199734.258097958807540.01295179875054610.0461096574075635
ELK4#2005210.8237877723120.01091284719516480.0401849957060791
ESR1#2099220.51240219743630.003099741577095180.0163057273380801
FOSL1#8061226.47571981091530.001869833702590980.0110236275509398
FOSL2#2355211.28680040304110.0100534586973120.0376658477862162
GATA3#2625218.15767757147070.003944546819279620.018943510611061
HNF4G#3174219.16894835096450.003543986611284220.0179701130114052
JUNB#3726220.40708843988080.003131462199438740.016446081698038
MAX#414936.452555509007120.003721913834265510.0186156294687446
MEF2A#4205212.4954872730960.008235029478029740.0324819942463913
MYC#460935.22228187160940.007020843755740150.0293875957278564
NFKB1#479035.488063424193840.006049381815655430.0269110783935442
NR3C1#2908314.9730233311730.0002978331194675480.00308309972882063
PAX5#507936.669565531177830.003370290999677260.0172620186217102
RAD21#5885310.35503389545630.0009004912073565420.00662905485339465
RXRA#6256213.38307809275550.007196434429465730.0298213869530997
SIN3A#2594235.408884726815140.006318961977991520.027596640880633
SMARCB1#6598212.16847718743830.008675002221921740.032975743659883
SMC3#9126315.04493284493280.0002935825420371870.00308496499726549
SRF#6722313.79717826216780.0003806615025800190.00374455181953043
TFAP2C#7022310.80922860986020.0007916746575753130.0061418592751826
USF1#739136.361499277207960.00388404057290560.018990885458506
ZNF263#1012738.221841637010680.001799043925565870.0109143391543523



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.


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