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Coexpression cluster:C625

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Full id: C625_CD14_Neutrophils_Basophils_CD14CD16_Peripheral_Eosinophils_Macrophage



Phase1 CAGE Peaks

Hg19::chr12:133065321..133065365,+p@chr12:133065321..133065365
+
Hg19::chr12:69742296..69742328,-p@chr12:69742296..69742328
-
Hg19::chr12:69747672..69747700,-p2@ENST00000548626
Hg19::chr12:69747723..69747752,-p1@ENST00000548900
Hg19::chr17:7077743..7077758,-p@chr17:7077743..7077758
-
Hg19::chr17:7077765..7077789,-p@chr17:7077765..7077789
-
Hg19::chr1:10057107..10057116,+p5@RBP7
Hg19::chr22:41418135..41418155,+p@chr22:41418135..41418155
+
Hg19::chr7:36764004..36764059,-p1@AOAH
Hg19::chr7:36764062..36764124,-p2@AOAH
Hg19::chr7:36764142..36764157,-p6@AOAH
Hg19::chrX:152086373..152086414,+p3@ZNF185
Hg19::chrX:152086415..152086444,+p5@ZNF185
Hg19::chrX:152086449..152086473,+p4@ZNF185


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0050528acyloxyacyl hydrolase activity0.00468032497350759
GO:0004465lipoprotein lipase activity0.00842260114111378
GO:0031348negative regulation of defense response0.00842260114111378
GO:0019841retinol binding0.00842260114111378
GO:0050728negative regulation of inflammatory response0.00842260114111378
GO:0016918retinal binding0.00883645061134167
GO:0008653lipopolysaccharide metabolic process0.00883645061134167
GO:0005501retinoid binding0.00883645061134167
GO:0019840isoprenoid binding0.00883645061134167
GO:0050727regulation of inflammatory response0.0106295889560112
GO:0031347regulation of defense response0.0106295889560112
GO:0048583regulation of response to stimulus0.0136372896623196
GO:0044264cellular polysaccharide metabolic process0.0286786892116701
GO:0005976polysaccharide metabolic process0.0286786892116701
GO:0016298lipase activity0.0438139912943119



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
monopoietic cell2.33e-7059
monocyte2.33e-7059
monoblast2.33e-7059
promonocyte2.33e-7059
macrophage dendritic cell progenitor9.43e-7061
defensive cell4.51e-6948
phagocyte4.51e-6948
myeloid leukocyte1.41e-6672
granulocyte monocyte progenitor cell4.13e-6467
myeloid lineage restricted progenitor cell7.57e-6166
classical monocyte1.21e-6042
CD14-positive, CD16-negative classical monocyte1.21e-6042
myeloid cell1.65e-49108
common myeloid progenitor1.65e-49108
leukocyte3.25e-43136
nongranular leukocyte9.40e-42115
hematopoietic stem cell1.43e-39168
angioblastic mesenchymal cell1.43e-39168
hematopoietic cell3.09e-36177
hematopoietic lineage restricted progenitor cell1.18e-35120
hematopoietic oligopotent progenitor cell2.47e-34161
hematopoietic multipotent progenitor cell2.47e-34161
stuff accumulating cell3.94e-3087
intermediate monocyte3.23e-159
CD14-positive, CD16-positive monocyte3.23e-159
macrophage1.62e-096
mesenchymal cell7.39e-08354
connective tissue cell2.54e-07361
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.03e-6998
blood island1.03e-6998
hemolymphoid system8.74e-65108
bone marrow2.65e-5676
immune system1.88e-5293
bone element1.05e-5082
skeletal element2.06e-4490
skeletal system5.59e-38100
lateral plate mesoderm1.65e-25203
musculoskeletal system1.16e-16167
adult organism2.49e-16114
blood2.64e-1215
haemolymphatic fluid2.64e-1215
organism substance2.64e-1215
mesoderm7.15e-12315
mesoderm-derived structure7.15e-12315
presumptive mesoderm7.15e-12315
connective tissue5.48e-07371


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.135551
MA0004.10.757232
MA0006.10.152601
MA0007.10.260673
MA0009.11.66167
MA0014.10.298852
MA0017.10.181071
MA0019.10.403106
MA0024.10.59663
MA0025.10.824398
MA0027.12.28954
MA0028.10.492785
MA0029.10.614815
MA0030.10.604021
MA0031.10.543644
MA0038.10.363295
MA0040.10.620334
MA0041.10.291389
MA0042.10.264992
MA0043.10.69629
MA0046.10.685589
MA0048.10.800598
MA0050.10.265714
MA0051.10.359609
MA0052.10.623986
MA0055.10.148782
MA0056.10
MA0057.11.12385
MA0058.10.580064
MA0059.10.199079
MA0060.10.0773489
MA0061.10.224865
MA0063.10
MA0066.10.953901
MA0067.11.00375
MA0068.10.169955
MA0069.10.681911
MA0070.10.671241
MA0071.10.878639
MA0072.11.60126
MA0073.10.385259
MA0074.11.68271
MA0076.11.14644
MA0077.10.65962
MA0078.10.447828
MA0081.10.578007
MA0083.10.703169
MA0084.11.18798
MA0087.11.5964
MA0088.10.14098
MA0089.10
MA0090.10.223576
MA0091.10.278153
MA0092.10.247341
MA0093.10.915249
MA0095.10
MA0098.10
MA0100.10.375452
MA0101.10.475507
MA0103.10.146091
MA0105.10.225264
MA0106.10.399649
MA0107.10.107387
MA0108.20.540797
MA0109.10
MA0111.10.660878
MA0113.10.414278
MA0114.10.104181
MA0115.10.929032
MA0116.10.354243
MA0117.10.732
MA0119.10.18693
MA0122.10.756889
MA0124.10.888592
MA0125.11.89135
MA0130.10
MA0131.11.17298
MA0132.10
MA0133.10
MA0135.11.72198
MA0136.10.369468
MA0139.10.0564547
MA0140.10.327488
MA0141.10.197753
MA0142.10.514195
MA0143.11.06513
MA0144.10.0953756
MA0145.10.827687
MA0146.10.0121843
MA0147.10.36013
MA0148.10.296708
MA0149.10.319221
MA0062.21.73596
MA0035.20.326883
MA0039.20.102019
MA0138.20.44894
MA0002.20.248488
MA0137.20.168782
MA0104.20.265556
MA0047.20.388882
MA0112.20.78415
MA0065.20.16797
MA0150.10.218956
MA0151.10
MA0152.10.333125
MA0153.10.790794
MA0154.10.219649
MA0155.10.486086
MA0156.10.170442
MA0157.10.489002
MA0158.10
MA0159.10.361202
MA0160.10.30953
MA0161.10
MA0162.10.00136062
MA0163.10.0498121
MA0164.10.425415
MA0080.20.46983
MA0018.20.400879
MA0099.20.333432
MA0079.20.162035
MA0102.21.22472
MA0258.11.04518
MA0259.10.117259
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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