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Coexpression cluster:C4640

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Full id: C4640_CD14CD16_CD19_Neutrophils_Burkitt_migratory_Eosinophils_Dendritic



Phase1 CAGE Peaks

Hg19::chr7:106505874..106505906,+p2@PIK3CG
Hg19::chr7:106505912..106505931,+p5@PIK3CG
Hg19::chr7:106505940..106505955,+p7@PIK3CG


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell2.03e-70168
angioblastic mesenchymal cell2.03e-70168
hematopoietic cell3.55e-66177
leukocyte1.46e-63136
hematopoietic oligopotent progenitor cell9.74e-63161
hematopoietic multipotent progenitor cell9.74e-63161
nongranular leukocyte3.34e-45115
hematopoietic lineage restricted progenitor cell5.17e-44120
myeloid cell3.10e-42108
common myeloid progenitor3.10e-42108
myeloid leukocyte1.66e-3472
granulocyte monocyte progenitor cell6.93e-2967
classical monocyte6.15e-2742
CD14-positive, CD16-negative classical monocyte6.15e-2742
myeloid lineage restricted progenitor cell2.24e-2666
defensive cell7.78e-2548
phagocyte7.78e-2548
macrophage dendritic cell progenitor1.40e-2461
monopoietic cell2.38e-2459
monocyte2.38e-2459
monoblast2.38e-2459
promonocyte2.38e-2459
lymphocyte of B lineage6.05e-2224
pro-B cell6.05e-2224
lymphocyte2.36e-1753
common lymphoid progenitor2.36e-1753
lymphoid lineage restricted progenitor cell1.72e-1652
B cell1.89e-1614
nucleate cell2.57e-1655
mesenchymal cell6.05e-15354
connective tissue cell4.74e-14361
dendritic cell1.17e-1110
motile cell5.61e-11386
conventional dendritic cell2.90e-098
intermediate monocyte3.42e-099
CD14-positive, CD16-positive monocyte3.42e-099
granulocyte1.31e-088
stuff accumulating cell1.50e-0887
stem cell5.90e-08441
multi fate stem cell8.36e-08427
somatic stem cell2.50e-07433
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.10e-3798
blood island5.10e-3798
hemolymphoid system3.30e-34108
immune system3.41e-2793
bone marrow2.50e-2676
bone element3.45e-2382
skeletal element1.09e-1990
skeletal system3.68e-16100
connective tissue2.78e-13371
lateral plate mesoderm1.18e-12203
blood6.58e-0815
haemolymphatic fluid6.58e-0815
organism substance6.58e-0815
Disease
Ontology termp-valuen
hematologic cancer3.96e-0951
immune system cancer3.96e-0951


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538324.35780179230366.91705216281876e-050.0011022429216244
ELF1#199734.258097958807540.01295179875054610.0464788135143553
GATA2#2624312.7449317335540.0004829527704283790.00438906233821524
NFKB1#479035.488063424193840.006049381815655430.0270806424108546
SPI1#668838.204323508522730.001810593189410520.0109405543918563



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.