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Coexpression cluster:C1458

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Full id: C1458_cerebellum_small_temporal_parietal_occipital_somatostatinoma_neuroectodermal



Phase1 CAGE Peaks

  Short description
Hg19::chr19:7939079..7939096,- p@chr19:7939079..7939096
-
Hg19::chr7:29233853..29233864,+ p15@CHN2
Hg19::chr7:29234032..29234043,+ p16@CHN2
Hg19::chr7:29234101..29234130,+ p6@CHN2
Hg19::chr7:29234147..29234156,+ p24@CHN2
Hg19::chr7:29323567..29323571,+ p@chr7:29323567..29323571
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
neural tube1.61e-4256
neural rod1.61e-4256
future spinal cord1.61e-4256
neural keel1.61e-4256
regional part of nervous system7.93e-3953
regional part of brain7.93e-3953
central nervous system1.95e-3781
adult organism9.74e-37114
nervous system2.61e-3689
brain1.23e-3368
future brain1.23e-3368
regional part of forebrain3.66e-3241
forebrain3.66e-3241
anterior neural tube3.66e-3241
future forebrain3.66e-3241
neurectoderm4.00e-2986
neural plate1.47e-2582
presumptive neural plate1.47e-2582
telencephalon2.49e-2434
brain grey matter2.68e-2434
gray matter2.68e-2434
organ system subdivision2.96e-22223
regional part of telencephalon8.56e-2232
cerebral hemisphere9.28e-2232
pre-chordal neural plate2.61e-1961
ecto-epithelium4.83e-19104
regional part of cerebral cortex2.42e-1822
ectoderm-derived structure1.31e-16171
ectoderm1.31e-16171
presumptive ectoderm1.31e-16171
neocortex4.50e-1620
cerebral cortex1.55e-1525
pallium1.55e-1525
structure with developmental contribution from neural crest1.66e-13132
posterior neural tube2.97e-1115
chordal neural plate2.97e-1115
neural nucleus1.07e-109
nucleus of brain1.07e-109
organ5.18e-10503
tube9.88e-10192
diencephalon1.33e-097
future diencephalon1.33e-097
basal ganglion4.21e-089
nuclear complex of neuraxis4.21e-089
aggregate regional part of brain4.21e-089
collection of basal ganglia4.21e-089
cerebral subcortex4.21e-089
telencephalic nucleus4.93e-087
segmental subdivision of hindbrain6.85e-0812
hindbrain6.85e-0812
presumptive hindbrain6.85e-0812
anatomical cluster1.06e-07373
multi-cellular organism1.10e-07656
segmental subdivision of nervous system3.92e-0713
brainstem9.99e-076
Disease
Ontology termp-valuen
neuroectodermal tumor1.01e-0710


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.14318
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.12.54844
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.11.45353
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.808182
MA0056.10
MA0057.14.31533
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.11.09642
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.14.94062
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.660742
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.857383
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.641617
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.707171
MA0146.12.38407
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.20.621793
MA0039.21.13151
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.22.92225
MA0065.21.18263
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.11.92418
MA0155.10.318517
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.347838
MA0163.15.08954
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.28.50593
MA0102.21.58513
MA0258.10.788656
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SUZ12#23512433.41052060737532.29902183370319e-068.18920672885836e-05



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.