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Coexpression cluster:C2639

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Full id: C2639_Smooth_large_Endothelial_Aortic_osteosarcoma_Preadipocyte_Renal



Phase1 CAGE Peaks

  Short description
Hg19::chr22:21134295..21134309,+ +
p@chr22:21134295..21134309
Hg19::chr22:21138297..21138307,+ p@chr22:21138297..21138307
+
Hg19::chr22:21138313..21138336,+ p@chr22:21138313..21138336
+
Hg19::chr22:21138343..21138378,+ p@chr22:21138343..21138378
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
vascular associated smooth muscle cell5.89e-2832
mesodermal cell3.61e-23121
blood vessel endothelial cell1.60e-2118
embryonic blood vessel endothelial progenitor cell1.60e-2118
smooth muscle cell1.60e-2043
smooth muscle myoblast1.60e-2043
endothelial cell of vascular tree4.36e-1924
muscle cell1.76e-1855
muscle precursor cell4.33e-1758
myoblast4.33e-1758
multi-potent skeletal muscle stem cell4.33e-1758
contractile cell1.17e-1659
electrically responsive cell7.67e-1661
electrically active cell7.67e-1661
endothelial cell of artery2.01e-139
endothelial cell1.19e-1236
aortic smooth muscle cell2.29e-1210
embryonic cell3.19e-12250
vein endothelial cell1.59e-116
cardiocyte1.86e-0916
non-terminally differentiated cell3.49e-09106
meso-epithelial cell4.03e-0945
lining cell1.00e-0858
barrier cell1.00e-0858
smooth muscle cell of the umbilical artery1.70e-084
somatic cell3.39e-08588
aortic endothelial cell3.46e-086
smooth muscle cell of the coronary artery4.46e-073
smooth muscle cell of the subclavian artery8.29e-075
Uber Anatomy
Ontology termp-valuen
artery3.47e-4942
arterial blood vessel3.47e-4942
arterial system3.47e-4942
epithelial tube open at both ends3.49e-4859
blood vessel3.49e-4859
blood vasculature3.49e-4859
vascular cord3.49e-4859
vessel6.02e-4468
splanchnic layer of lateral plate mesoderm8.97e-4383
epithelial tube3.10e-37117
systemic artery5.85e-3733
systemic arterial system5.85e-3733
vasculature1.91e-3678
vascular system1.91e-3678
cardiovascular system1.42e-31109
circulatory system2.67e-30112
unilaminar epithelium1.82e-23148
blood vessel endothelium1.60e-2118
endothelium1.60e-2118
cardiovascular system endothelium1.60e-2118
aorta4.66e-2021
aortic system4.66e-2021
tube1.53e-18192
simple squamous epithelium8.86e-1722
anatomical conduit1.13e-15240
skeletal muscle tissue1.87e-1562
striated muscle tissue1.87e-1562
myotome1.87e-1562
muscle tissue1.02e-1464
musculature1.02e-1464
musculature of body1.02e-1464
squamous epithelium3.12e-1425
somite1.21e-1371
presomitic mesoderm1.21e-1371
presumptive segmental plate1.21e-1371
dermomyotome1.21e-1371
trunk paraxial mesoderm1.21e-1371
lateral plate mesoderm1.58e-13203
endothelial tube2.01e-139
arterial system endothelium2.01e-139
endothelium of artery2.01e-139
paraxial mesoderm2.43e-1372
presumptive paraxial mesoderm2.43e-1372
dense mesenchyme tissue4.80e-1373
epithelial vesicle8.16e-1378
blood vessel smooth muscle2.29e-1210
arterial system smooth muscle2.29e-1210
artery smooth muscle tissue2.29e-1210
aorta smooth muscle tissue2.29e-1210
trunk mesenchyme1.77e-11122
multilaminar epithelium1.90e-1183
mesoderm1.12e-10315
mesoderm-derived structure1.12e-10315
presumptive mesoderm1.12e-10315
cell layer1.48e-10309
epithelium2.75e-10306
umbilical blood vessel6.19e-109
smooth muscle tissue2.36e-0915
umbilical artery1.70e-084
anatomical cluster6.87e-08373
mesenchyme1.48e-07160
entire embryonic mesenchyme1.48e-07160
vein2.36e-079
venous blood vessel2.36e-079
venous system2.36e-079
coronary artery4.46e-073
heart7.91e-0724
primitive heart tube7.91e-0724
primary heart field7.91e-0724
anterior lateral plate mesoderm7.91e-0724
heart tube7.91e-0724

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.12.32784
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.11.8408
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.12.5647
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.12.2938
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.22.51225
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.180766
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.13.02177
MA0160.11.78721
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187936.679850134926750.005184294118278910.0240534204095483
FOS#235348.99795530889440.0001525147711168630.00195082549671452
GATA2#262439.55869880016550.001818151618357440.0109029591679853
JUN#3725412.51282919233634.07770316866756e-050.00074400985540264



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.