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Coexpression cluster:C3412

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Full id: C3412_Smooth_Aortic_mesenchymal_CD14_Endothelial_Fibroblast_Osteoblast



Phase1 CAGE Peaks

  Short description
Hg19::chr14:23305848..23305863,+ p3@MMP14
Hg19::chr14:23305868..23305889,+ p4@MMP14
Hg19::chr14:23305909..23305918,+ p5@MMP14


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
somatic cell2.02e-26588
mesodermal cell7.80e-24121
contractile cell2.16e-1959
muscle precursor cell3.71e-1958
myoblast3.71e-1958
multi-potent skeletal muscle stem cell3.71e-1958
smooth muscle cell8.61e-1943
smooth muscle myoblast8.61e-1943
muscle cell2.12e-1855
non-terminally differentiated cell9.16e-18106
embryonic cell1.83e-17250
vascular associated smooth muscle cell2.53e-1632
electrically responsive cell1.16e-1561
electrically active cell1.16e-1561
animal cell5.49e-14679
eukaryotic cell5.49e-14679
multi fate stem cell9.08e-11427
somatic stem cell1.82e-10433
stem cell2.11e-09441
fibroblast4.47e-0976
endothelial cell8.65e-0936
meso-epithelial cell3.01e-0845
lining cell1.67e-0758
barrier cell1.67e-0758
aortic smooth muscle cell2.99e-0710
blood vessel endothelial cell9.95e-0718
embryonic blood vessel endothelial progenitor cell9.95e-0718
Uber Anatomy
Ontology termp-valuen
mesoderm1.43e-25315
mesoderm-derived structure1.43e-25315
presumptive mesoderm1.43e-25315
artery1.75e-2242
arterial blood vessel1.75e-2242
arterial system1.75e-2242
splanchnic layer of lateral plate mesoderm3.00e-2283
epithelial tube open at both ends8.40e-2259
blood vessel8.40e-2259
blood vasculature8.40e-2259
vascular cord8.40e-2259
vasculature1.81e-2178
vascular system1.81e-2178
multilaminar epithelium3.34e-2183
vessel1.88e-2068
epithelial vesicle1.28e-1978
musculoskeletal system3.26e-19167
somite5.92e-1971
presomitic mesoderm5.92e-1971
presumptive segmental plate5.92e-1971
dermomyotome5.92e-1971
trunk paraxial mesoderm5.92e-1971
dense mesenchyme tissue1.46e-1873
paraxial mesoderm1.87e-1872
presumptive paraxial mesoderm1.87e-1872
systemic artery2.95e-1833
systemic arterial system2.95e-1833
skeletal muscle tissue4.53e-1862
striated muscle tissue4.53e-1862
myotome4.53e-1862
epithelial tube6.91e-18117
muscle tissue1.45e-1764
musculature1.45e-1764
musculature of body1.45e-1764
unilaminar epithelium4.62e-16148
multi-cellular organism7.08e-16656
cardiovascular system6.58e-15109
lateral plate mesoderm7.23e-15203
circulatory system3.21e-14112
anatomical system4.17e-14624
anatomical group8.41e-14625
trunk mesenchyme8.77e-14122
mesenchyme4.77e-12160
entire embryonic mesenchyme4.77e-12160
aorta1.29e-1121
aortic system1.29e-1121
embryonic structure3.33e-11564
developing anatomical structure9.40e-11581
germ layer3.11e-10560
germ layer / neural crest3.11e-10560
embryonic tissue3.11e-10560
presumptive structure3.11e-10560
germ layer / neural crest derived structure3.11e-10560
epiblast (generic)3.11e-10560
organism subdivision5.02e-10264
embryo5.84e-10592
trunk1.22e-09199
cell layer2.16e-08309
epithelium2.32e-08306
blood vessel smooth muscle2.99e-0710
arterial system smooth muscle2.99e-0710
artery smooth muscle tissue2.99e-0710
aorta smooth muscle tissue2.99e-0710
smooth muscle tissue5.63e-0715
blood vessel endothelium9.95e-0718
endothelium9.95e-0718
cardiovascular system endothelium9.95e-0718
Disease
Ontology termp-valuen
ovarian cancer1.99e-0714


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.11.70014
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.11.74184
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.13.97071
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.13.29283
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.21.15986
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.11.51687
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488362.71700033932814.049570681927e-060.000129258286201031
CTCF#1066435.360256373075030.0064925092527670.0278800696455628
MAFK#7975327.10073313782995.02195559325033e-050.000856866558084417
RAD21#5885310.35503389545630.0009004912073565420.0066276533618823



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.