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Coexpression cluster:C4206

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Full id: C4206_Smooth_Keratinocyte_mesenchymal_Fibroblast_Bronchial_mucinous_Tracheal



Phase1 CAGE Peaks

Hg19::chr2:239335353..239335391,+p4@ASB1
Hg19::chr2:239335396..239335448,+p3@ASB1
Hg19::chr2:239335449..239335460,+p7@ASB1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
artery2.37e-2142
arterial blood vessel2.37e-2142
arterial system2.37e-2142
blood vessel7.55e-1860
epithelial tube open at both ends7.55e-1860
blood vasculature7.55e-1860
vascular cord7.55e-1860
systemic artery8.38e-1833
systemic arterial system8.38e-1833
vessel3.02e-1769
splanchnic layer of lateral plate mesoderm3.22e-1784
vasculature5.78e-1779
vascular system5.78e-1779
epithelial tube3.10e-16118
mesoderm2.28e-13448
mesoderm-derived structure2.28e-13448
presumptive mesoderm2.28e-13448
musculoskeletal system3.13e-13167
unilaminar epithelium4.46e-13138
cardiovascular system1.16e-12110
dermomyotome3.47e-1270
multilaminar epithelium5.02e-1282
circulatory system7.91e-12113
skeletal muscle tissue3.01e-1161
striated muscle tissue3.01e-1161
myotome3.01e-1161
anatomical system3.62e-11625
lateral plate mesoderm3.89e-11216
somite4.55e-1183
paraxial mesoderm4.55e-1183
presomitic mesoderm4.55e-1183
presumptive segmental plate4.55e-1183
trunk paraxial mesoderm4.55e-1183
presumptive paraxial mesoderm4.55e-1183
anatomical group5.59e-11626
aorta1.30e-1021
aortic system1.30e-1021
muscle tissue2.35e-1063
musculature2.35e-1063
musculature of body2.35e-1063
trunk mesenchyme5.86e-10143
multi-cellular organism1.78e-09659
trunk4.78e-08216
epithelium1.39e-07309
cell layer3.63e-07312
germ layer5.21e-07604
embryonic tissue5.21e-07604
presumptive structure5.21e-07604
epiblast (generic)5.21e-07604
embryonic structure6.50e-07605
developing anatomical structure6.50e-07605
blood vessel smooth muscle7.62e-0710
arterial system smooth muscle7.62e-0710
artery smooth muscle tissue7.62e-0710
aorta smooth muscle tissue7.62e-0710
Disease
Ontology termp-valuen
ovarian cancer4.06e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0326301410095763
EGR1#195834.988179094810140.008056488137383440.0321456185130922
ELF1#199734.258097958807540.01295179875054610.0463529884760566
ELK4#2005316.2356816584680.0002336043955745990.00256033261301454
ETS1#211339.728760922202340.001085840092584840.00763715088083155
GABPB1#255337.067683836182170.002832212825417420.0154461344790481
NFKB1#479035.488063424193840.006049381815655430.0270169505001171
PAX5#507936.669565531177830.003370290999677260.0173283031415987
REST#597839.650028716128020.001112636247114590.00769349953736763
RFX5#5993312.04791082719510.0005717246050312580.00485528915472919
TFAP2A#7020316.5186343730450.0002218033880766340.00248790935961074
TFAP2C#7022310.80922860986020.0007916746575753130.00617165854762321



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.