Coexpression cluster:C2284

Full id: C2284_occipital_brain_hippocampus_medial_medulla_amygdala_cerebellum

Phase1 CAGE Peaks

Hg19::chr14:21490590..21490616,-	p8@NDRG2
Hg19::chr14:21490622..21490648,-	p9@NDRG2
Hg19::chr14:21490653..21490665,-	p14@NDRG2
Hg19::chr3:121613362..121613373,+	p4@SLC15A2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015334	high affinity oligopeptide transporter activity	0.00204086638570241
GO:0022897	proton-dependent peptide secondary active transmembrane transporter activity	0.00204086638570241
GO:0015333	peptide:hydrogen symporter activity	0.00204086638570241
GO:0015295	solute:hydrogen symporter activity	0.00306120946214148
GO:0015198	oligopeptide transporter activity	0.00367334321487522
GO:0015197	peptide transporter activity	0.00408137230575627
GO:0006857	oligopeptide transport	0.00650382537410799
GO:0015893	drug transport	0.00650382537410799
GO:0015833	peptide transport	0.0132584071746926
GO:0042493	response to drug	0.0192688714762954
GO:0015294	solute:cation symporter activity	0.0316738953436382

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	1.09e-68	115
neural tube	1.85e-40	57
neural rod	1.85e-40	57
future spinal cord	1.85e-40	57
neural keel	1.85e-40	57
regional part of brain	1.41e-32	59
central nervous system	2.30e-30	82
neural plate	2.44e-30	86
presumptive neural plate	2.44e-30	86
neurectoderm	9.66e-30	90
anterior neural tube	3.42e-29	42
regional part of forebrain	2.11e-28	41
forebrain	2.11e-28	41
future forebrain	2.11e-28	41
brain	2.67e-28	69
future brain	2.67e-28	69
gray matter	1.80e-26	34
brain grey matter	1.80e-26	34
telencephalon	2.75e-26	34
regional part of nervous system	2.86e-26	94
nervous system	2.86e-26	94
regional part of telencephalon	1.88e-25	33
cerebral hemisphere	1.48e-24	32
regional part of cerebral cortex	7.57e-22	22
neocortex	7.79e-20	20
pre-chordal neural plate	3.22e-18	61
cerebral cortex	3.62e-18	25
pallium	3.62e-18	25
anterior region of body	1.30e-17	129
craniocervical region	1.30e-17	129
head	3.63e-17	123
ectoderm	1.32e-15	173
presumptive ectoderm	1.32e-15	173
ectoderm-derived structure	1.44e-15	169
posterior neural tube	3.60e-12	15
chordal neural plate	3.60e-12	15
anatomical conduit	1.30e-11	241
tube	1.43e-10	194
segmental subdivision of nervous system	3.21e-10	13
basal ganglion	6.16e-10	9
nuclear complex of neuraxis	6.16e-10	9
aggregate regional part of brain	6.16e-10	9
collection of basal ganglia	6.16e-10	9
cerebral subcortex	6.16e-10	9
nucleus of brain	6.68e-10	9
neural nucleus	6.68e-10	9
segmental subdivision of hindbrain	2.07e-09	12
hindbrain	2.07e-09	12
presumptive hindbrain	2.07e-09	12
anatomical cluster	4.06e-09	286
organ	5.78e-09	511
brainstem	1.08e-08	8
temporal lobe	1.84e-08	7
multi-tissue structure	1.86e-08	347
telencephalic nucleus	5.16e-08	7
organ part	4.40e-07	219
gyrus	5.07e-07	6

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.