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{{Coexpression_clusters
{
|full_id=C1653_choriocarcinoma_Endothelial_pancreatic_placenta_lung_Lymphatic_adipose

Latest revision as of 11:49, 17 September 2013


Full id: C1653_choriocarcinoma_Endothelial_pancreatic_placenta_lung_Lymphatic_adipose



Phase1 CAGE Peaks

Hg19::chr12:10251519..10251526,-p5@CLEC1A
Hg19::chr12:10251539..10251560,-p2@CLEC1A
Hg19::chr12:10251576..10251599,-p1@CLEC1A
Hg19::chr12:10251603..10251619,-p3@CLEC1A
Hg19::chr12:10251621..10251628,-p4@CLEC1A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism7.55e-46114
blood vessel endothelium7.86e-2418
endothelium7.86e-2418
cardiovascular system endothelium7.86e-2418
simple squamous epithelium2.04e-1822
anatomical conduit3.46e-18240
tube2.72e-16192
neural tube7.12e-1656
neural rod7.12e-1656
future spinal cord7.12e-1656
neural keel7.12e-1656
squamous epithelium1.62e-1525
anatomical cluster3.38e-14373
regional part of nervous system1.56e-1353
regional part of brain1.56e-1353
vessel4.07e-1268
neural plate1.93e-1182
presumptive neural plate1.93e-1182
chorion2.92e-117
endothelial tube6.85e-119
arterial system endothelium6.85e-119
endothelium of artery6.85e-119
regional part of forebrain1.32e-1041
forebrain1.32e-1041
anterior neural tube1.32e-1041
future forebrain1.32e-1041
central nervous system1.61e-1081
neurectoderm1.81e-1086
splanchnic layer of lateral plate mesoderm9.51e-1083
extraembryonic membrane1.07e-0914
membranous layer1.07e-0914
vasculature1.92e-0978
vascular system1.92e-0978
brain2.37e-0968
future brain2.37e-0968
multi-cellular organism6.26e-09656
nervous system1.33e-0889
anatomical system1.62e-08624
vein1.63e-089
venous blood vessel1.63e-089
venous system1.63e-089
anatomical group1.89e-08625
epithelial tube open at both ends3.30e-0859
blood vessel3.30e-0859
blood vasculature3.30e-0859
vascular cord3.30e-0859
brain grey matter3.86e-0834
gray matter3.86e-0834
telencephalon5.18e-0834
epithelium6.93e-08306
structure with developmental contribution from neural crest8.68e-08132
cell layer1.23e-07309
lymphatic vessel1.24e-078
lymph vasculature1.24e-078
lymphatic part of lymphoid system1.24e-078
lymphoid system1.58e-0710
brainstem1.91e-076
placenta2.30e-074
allantois2.30e-074
ecto-epithelium4.01e-07104
organ part6.19e-07218
regional part of telencephalon7.02e-0732
posterior neural tube9.00e-0715
chordal neural plate9.00e-0715
circulatory system9.02e-07112
cerebral hemisphere9.34e-0732


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.80249
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.11.84387
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.12.31153
MA0031.13.57633
MA0038.11.7452
MA0040.12.34794
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.11.66737
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.11.43794
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.946108
MA0147.10.386018
MA0148.12.65967
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0575907
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.21.80892
MA0112.21.96224
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.13.38501
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.146371
MA0102.21.66336
MA0258.12.47453
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TAF1#687253.343046285745290.002394600090870310.0135183588589408



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.