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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.430944806228759,

Latest revision as of 12:16, 17 September 2013


Full id: C2936_CD14_parotid_salivary_submaxillary_corpus_Mallassezderived_substantia



Phase1 CAGE Peaks

Hg19::chr9:115913230..115913266,+p2@SLC31A2
Hg19::chr9:115913271..115913298,+p1@SLC31A2
Hg19::chr9:115913314..115913325,+p3@SLC31A2
Hg19::chr9:115915412..115915416,+p@chr9:115915412..115915416
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
hematopoietic system2.91e-2598
blood island2.91e-2598
hemolymphoid system2.29e-24108
bone marrow5.94e-2376
immune system2.48e-2093
adult organism5.52e-19114
bone element1.03e-1882
skeletal element2.04e-1890
skeletal system8.87e-17100
embryonic structure2.82e-09564
anatomical system1.06e-08624
musculoskeletal system1.13e-08167
germ layer1.23e-08560
germ layer / neural crest1.23e-08560
embryonic tissue1.23e-08560
presumptive structure1.23e-08560
germ layer / neural crest derived structure1.23e-08560
epiblast (generic)1.23e-08560
anatomical group1.65e-08625
organ1.97e-08503
neural tube6.51e-0856
neural rod6.51e-0856
future spinal cord6.51e-0856
neural keel6.51e-0856
developing anatomical structure7.16e-08581
regional part of nervous system4.47e-0753
regional part of brain4.47e-0753
multi-cellular organism9.77e-07656


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.443649
MA0004.12.8475
MA0006.11.31813
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.14.12236
MA0041.10.732902
MA0042.11.66514
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.791759
MA0056.10
MA0057.10.248209
MA0058.16.23635
MA0059.16.22663
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.11.70187
MA0092.10.673508
MA0093.13.35176
MA0095.10
MA0098.10
MA0100.13.24733
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.12.76745
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.11.16748
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.21.79838
MA0047.20.856092
MA0112.20.187982
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.14.24646
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.122011
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467316.84738089450660.0003409986823655640.00346536551401938
CCNT2#90534.752151182721970.01386206996689490.0487504032485616
CHD2#110637.758017125587640.003351522464536340.0173084930363305
CTCF#1066445.360256373075030.001211145381643620.00820676133870618
CTCFL#140690314.80985576923080.0004996291767563340.00441163101042059
ETS1#211337.296570691651750.00400857377511390.0192165352290058
HMGN3#932436.133910792512940.006640696683324720.0283173167119774
MAX#414934.839416631755340.01315737137836840.0466475222141833
SIX5#147912312.81503651659420.0007664471136930380.00601766426905632
SMC3#9126311.28369963369960.001115802366868050.00766111915017637
USF1#739134.771124457905970.01370465887188020.0483433265079303
USF2#739239.74414803880220.001718341848410070.0107275930603204
ZBTB33#10009323.74854377248590.0001229451908818380.00165659563804777
ZBTB7A#5134135.513931980906920.009038352821081090.0342646386540668
ZNF143#7702310.12565741417090.001534861610688180.00977197096797509



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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