Coexpression cluster:C73: Difference between revisions
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|ontology_enrichment_celltype= | |ontology_enrichment_celltype= | ||
|ontology_enrichment_disease= | |ontology_enrichment_disease= | ||
|ontology_enrichment_uberon=UBERON: | |ontology_enrichment_uberon=UBERON:0001905!1.05e-79!2;UBERON:0002757!1.05e-79!2;UBERON:0010134!1.05e-79!2;UBERON:0005408!1.05e-79!2;UBERON:0001899!1.05e-79!2;UBERON:0003296!1.48e-40!4;UBERON:0010133!1.48e-40!4;UBERON:0002784!1.48e-40!4;UBERON:0001894!1.02e-23!7;UBERON:0006222!1.02e-23!7;UBERON:0002360!4.66e-21!2;UBERON:0000094!4.66e-21!2;UBERON:0010743!4.66e-21!2;UBERON:0002148!5.70e-21!2;UBERON:0006331!5.70e-21!2;UBERON:0009662!5.70e-21!2;UBERON:0000988!1.83e-14!3;UBERON:0007023!2.58e-09!114;UBERON:0001017!2.54e-08!81;UBERON:0003075!2.64e-08!82;UBERON:0007284!2.64e-08!82;UBERON:0002346!5.98e-08!86;UBERON:0002298!6.78e-08!6;UBERON:0000966!7.25e-08!6;UBERON:0005388!7.25e-08!6;UBERON:0001802!7.25e-08!6;UBERON:0001016!1.45e-07!89;UBERON:0000073!2.03e-07!53;UBERON:0002616!2.03e-07!53;UBERON:0001049!4.58e-07!56;UBERON:0005068!4.58e-07!56;UBERON:0006241!4.58e-07!56;UBERON:0007135!4.58e-07!56 | ||
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| ||
}} | }} |
Revision as of 16:38, 19 October 2012
Full id: C73_pineal_eye_retina_caudate_cerebellum_left_parietal
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0032501 | multicellular organismal process | 0.000798875022718607 |
GO:0007601 | visual perception | 0.000798875022718607 |
GO:0050953 | sensory perception of light stimulus | 0.000798875022718607 |
GO:0031226 | intrinsic to plasma membrane | 0.00116951587837936 |
GO:0006811 | ion transport | 0.00116951587837936 |
GO:0008048 | calcium sensitive guanylate cyclase activator activity | 0.00116951587837936 |
GO:0022836 | gated channel activity | 0.00117528981583149 |
GO:0030250 | guanylate cyclase activator activity | 0.00117528981583149 |
GO:0007275 | multicellular organismal development | 0.00117528981583149 |
GO:0030249 | guanylate cyclase regulator activity | 0.00146711139623314 |
GO:0022834 | ligand-gated channel activity | 0.00146711139623314 |
GO:0015276 | ligand-gated ion channel activity | 0.00146711139623314 |
GO:0015075 | ion transmembrane transporter activity | 0.00237469371938107 |
GO:0005887 | integral to plasma membrane | 0.00237469371938107 |
GO:0007271 | synaptic transmission, cholinergic | 0.00237469371938107 |
GO:0005216 | ion channel activity | 0.00237469371938107 |
GO:0030001 | metal ion transport | 0.00237469371938107 |
GO:0005261 | cation channel activity | 0.00237469371938107 |
GO:0022838 | substrate specific channel activity | 0.00237469371938107 |
GO:0004725 | protein tyrosine phosphatase activity | 0.00237469371938107 |
GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | 0.00237469371938107 |
GO:0022803 | passive transmembrane transporter activity | 0.00237469371938107 |
GO:0015267 | channel activity | 0.00237469371938107 |
GO:0031420 | alkali metal ion binding | 0.00238072514538406 |
GO:0009653 | anatomical structure morphogenesis | 0.00254613119626893 |
GO:0032502 | developmental process | 0.00264905827950136 |
GO:0022891 | substrate-specific transmembrane transporter activity | 0.00372411254189549 |
GO:0003008 | system process | 0.00383473901382672 |
GO:0046873 | metal ion transmembrane transporter activity | 0.00383473901382672 |
GO:0019198 | transmembrane receptor protein phosphatase activity | 0.00383473901382672 |
GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | 0.00383473901382672 |
GO:0015464 | acetylcholine receptor activity | 0.00455608242389527 |
GO:0006812 | cation transport | 0.00470718568945914 |
GO:0042166 | acetylcholine binding | 0.00470718568945914 |
GO:0022857 | transmembrane transporter activity | 0.00470718568945914 |
GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | 0.00487260502103891 |
GO:0008324 | cation transmembrane transporter activity | 0.00490553779108503 |
GO:0050877 | neurological system process | 0.00544917950786975 |
GO:0004721 | phosphoprotein phosphatase activity | 0.00544917950786975 |
GO:0005230 | extracellular ligand-gated ion channel activity | 0.00582568536965618 |
GO:0005886 | plasma membrane | 0.00582568536965618 |
GO:0022892 | substrate-specific transporter activity | 0.00659272152475054 |
GO:0030594 | neurotransmitter receptor activity | 0.00675336226925213 |
GO:0030955 | potassium ion binding | 0.00675336226925213 |
GO:0042165 | neurotransmitter binding | 0.00692763242553277 |
GO:0044459 | plasma membrane part | 0.00692763242553277 |
GO:0045211 | postsynaptic membrane | 0.0072743977899669 |
GO:0048666 | neuron development | 0.00779831101784334 |
GO:0042401 | biogenic amine biosynthetic process | 0.00779831101784334 |
GO:0007154 | cell communication | 0.00779831101784334 |
GO:0044456 | synapse part | 0.00839689705849121 |
GO:0042398 | amino acid derivative biosynthetic process | 0.0108324502531496 |
GO:0008016 | regulation of heart contraction | 0.0108324502531496 |
GO:0048856 | anatomical structure development | 0.0108324502531496 |
GO:0005578 | proteinaceous extracellular matrix | 0.0108324502531496 |
GO:0043176 | amine binding | 0.0108324502531496 |
GO:0007165 | signal transduction | 0.0108324502531496 |
GO:0008292 | acetylcholine biosynthetic process | 0.0108324502531496 |
GO:0043033 | isoamylase complex | 0.0108324502531496 |
GO:0045163 | clustering of voltage-gated potassium channels | 0.0108324502531496 |
GO:0005223 | intracellular cGMP activated cation channel activity | 0.0108324502531496 |
GO:0004059 | aralkylamine N-acetyltransferase activity | 0.0108324502531496 |
GO:0005307 | choline:sodium symporter activity | 0.0108324502531496 |
GO:0003015 | heart process | 0.0113021478812126 |
GO:0060047 | heart contraction | 0.0113021478812126 |
GO:0016791 | phosphoric monoester hydrolase activity | 0.0113021478812126 |
GO:0048858 | cell projection morphogenesis | 0.0122864640209472 |
GO:0032990 | cell part morphogenesis | 0.0122864640209472 |
GO:0030030 | cell projection organization and biogenesis | 0.0122864640209472 |
GO:0030182 | neuron differentiation | 0.0131595252074336 |
GO:0031224 | intrinsic to membrane | 0.0145126129353322 |
GO:0014059 | regulation of dopamine secretion | 0.0145126129353322 |
GO:0003099 | positive regulation of the force of heart contraction by chemical signal | 0.0145126129353322 |
GO:0001996 | positive regulation of heart rate by epinephrine-norepinephrine | 0.0145126129353322 |
GO:0014046 | dopamine secretion | 0.0145126129353322 |
GO:0021952 | central nervous system projection neuron axonogenesis | 0.0145126129353322 |
GO:0002025 | norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure | 0.0145126129353322 |
GO:0021955 | central nervous system neuron axonogenesis | 0.0145126129353322 |
GO:0003057 | regulation of the force of heart contraction by chemical signal | 0.0145126129353322 |
GO:0001997 | positive regulation of the force of heart contraction by epinephrine-norepinephrine | 0.0145126129353322 |
GO:0032225 | regulation of synaptic transmission, dopaminergic | 0.0145126129353322 |
GO:0004134 | 4-alpha-glucanotransferase activity | 0.0145126129353322 |
GO:0002021 | response to dietary excess | 0.0145126129353322 |
GO:0004133 | glycogen debranching enzyme activity | 0.0145126129353322 |
GO:0044246 | regulation of multicellular organismal metabolic process | 0.0145126129353322 |
GO:0007023 | post-chaperonin tubulin folding pathway | 0.0145126129353322 |
GO:0030187 | melatonin biosynthetic process | 0.0145126129353322 |
GO:0005250 | A-type (transient outward) potassium channel activity | 0.0145126129353322 |
GO:0044253 | positive regulation of multicellular organismal metabolic process | 0.0145126129353322 |
GO:0030186 | melatonin metabolic process | 0.0145126129353322 |
GO:0002024 | diet induced thermogenesis | 0.0145126129353322 |
GO:0004135 | amylo-alpha-1,6-glucosidase activity | 0.0145126129353322 |
GO:0017096 | acetylserotonin O-methyltransferase activity | 0.0145126129353322 |
GO:0004940 | beta1-adrenergic receptor activity | 0.0145126129353322 |
GO:0048699 | generation of neurons | 0.0145264542492445 |
GO:0006470 | protein amino acid dephosphorylation | 0.0152141450789577 |
GO:0015672 | monovalent inorganic cation transport | 0.0152141450789577 |
GO:0006813 | potassium ion transport | 0.0165129510798601 |
GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 0.0172768965547393 |
GO:0022008 | neurogenesis | 0.0172768965547393 |
GO:0006576 | biogenic amine metabolic process | 0.0179227437970209 |
GO:0042578 | phosphoric ester hydrolase activity | 0.0182609326219224 |
GO:0007600 | sensory perception | 0.0182609326219224 |
GO:0001505 | regulation of neurotransmitter levels | 0.0182609326219224 |
GO:0051239 | regulation of multicellular organismal process | 0.0182609326219224 |
GO:0015871 | choline transport | 0.0182609326219224 |
GO:0008291 | acetylcholine metabolic process | 0.0182609326219224 |
GO:0048814 | regulation of dendrite morphogenesis | 0.0182609326219224 |
GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | 0.0182609326219224 |
GO:0015220 | choline transmembrane transporter activity | 0.0182609326219224 |
GO:0010460 | positive regulation of heart rate | 0.0182609326219224 |
GO:0005641 | nuclear envelope lumen | 0.0182609326219224 |
GO:0016311 | dephosphorylation | 0.0184341090242922 |
GO:0051606 | detection of stimulus | 0.0185034313375373 |
GO:0007268 | synaptic transmission | 0.019986766021351 |
GO:0006575 | amino acid derivative metabolic process | 0.0216314411286028 |
GO:0050433 | regulation of catecholamine secretion | 0.0216314411286028 |
GO:0006930 | substrate-bound cell migration, cell extension | 0.0216314411286028 |
GO:0050773 | regulation of dendrite development | 0.0216314411286028 |
GO:0048813 | dendrite morphogenesis | 0.0216314411286028 |
GO:0004939 | beta-adrenergic receptor activity | 0.0216314411286028 |
GO:0031649 | heat generation | 0.0216314411286028 |
GO:0040015 | negative regulation of multicellular organism growth | 0.0216314411286028 |
GO:0015271 | outward rectifier potassium channel activity | 0.0216314411286028 |
GO:0030971 | receptor tyrosine kinase binding | 0.0216314411286028 |
GO:0050432 | catecholamine secretion | 0.0216314411286028 |
GO:0007267 | cell-cell signaling | 0.023109576764517 |
GO:0031402 | sodium ion binding | 0.0235294335981272 |
GO:0004888 | transmembrane receptor activity | 0.0238125713562054 |
GO:0019226 | transmission of nerve impulse | 0.0238125713562054 |
GO:0051179 | localization | 0.0238125713562054 |
GO:0008306 | associative learning | 0.0238125713562054 |
GO:0021954 | central nervous system neuron development | 0.0238125713562054 |
GO:0005221 | intracellular cyclic nucleotide activated cation channel activity | 0.0238125713562054 |
GO:0045823 | positive regulation of heart contraction | 0.0238125713562054 |
GO:0007025 | beta-tubulin folding | 0.0238125713562054 |
GO:0003085 | negative regulation of systemic arterial blood pressure | 0.0238125713562054 |
GO:0035094 | response to nicotine | 0.0238125713562054 |
GO:0045161 | neuronal ion channel clustering | 0.0238125713562054 |
GO:0001993 | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | 0.0238125713562054 |
GO:0042439 | ethanolamine and derivative metabolic process | 0.0238125713562054 |
GO:0043855 | cyclic nucleotide-gated ion channel activity | 0.0238125713562054 |
GO:0050873 | brown fat cell differentiation | 0.0238125713562054 |
GO:0043235 | receptor complex | 0.0272427144715925 |
GO:0042435 | indole derivative biosynthetic process | 0.0274102920841841 |
GO:0002027 | regulation of heart rate | 0.0274102920841841 |
GO:0030345 | structural constituent of tooth enamel | 0.0274102920841841 |
GO:0030296 | protein tyrosine kinase activator activity | 0.0274102920841841 |
GO:0046219 | indolalkylamine biosynthetic process | 0.0274102920841841 |
GO:0007409 | axonogenesis | 0.0280242580161238 |
GO:0016788 | hydrolase activity, acting on ester bonds | 0.0286889742953508 |
GO:0009309 | amine biosynthetic process | 0.0286889742953508 |
GO:0048667 | neuron morphogenesis during differentiation | 0.0286889742953508 |
GO:0048812 | neurite morphogenesis | 0.0286889742953508 |
GO:0016021 | integral to membrane | 0.0286889742953508 |
GO:0003876 | AMP deaminase activity | 0.0286889742953508 |
GO:0021953 | central nervous system neuron differentiation | 0.0286889742953508 |
GO:0046923 | ER retention sequence binding | 0.0286889742953508 |
GO:0030021 | extracellular matrix structural constituent conferring compression resistance | 0.0286889742953508 |
GO:0003084 | positive regulation of systemic arterial blood pressure | 0.0286889742953508 |
GO:0001963 | synaptic transmission, dopaminergic | 0.0286889742953508 |
GO:0002026 | regulation of the force of heart contraction | 0.0286889742953508 |
GO:0008503 | benzodiazepine receptor activity | 0.0286889742953508 |
GO:0042596 | fear response | 0.0286889742953508 |
GO:0001750 | photoreceptor outer segment | 0.0286889742953508 |
GO:0001659 | thermoregulation | 0.0286889742953508 |
GO:0008076 | voltage-gated potassium channel complex | 0.0289135533180154 |
GO:0005201 | extracellular matrix structural constituent | 0.0289135533180154 |
GO:0006810 | transport | 0.0289135533180154 |
GO:0000904 | cellular morphogenesis during differentiation | 0.0299930541085604 |
GO:0016020 | membrane | 0.030878977163308 |
GO:0009409 | response to cold | 0.0310851830955258 |
GO:0045776 | negative regulation of blood pressure | 0.0310851830955258 |
GO:0043279 | response to alkaloid | 0.0310851830955258 |
GO:0005513 | detection of calcium ion | 0.0310851830955258 |
GO:0051234 | establishment of localization | 0.0328901857088302 |
GO:0031175 | neurite development | 0.0328901857088302 |
GO:0006929 | substrate-bound cell migration | 0.0334248423292574 |
GO:0031513 | nonmotile primary cilium | 0.0334248423292574 |
GO:0051899 | membrane depolarization | 0.0334248423292574 |
GO:0007021 | tubulin folding | 0.0334248423292574 |
GO:0007274 | neuromuscular synaptic transmission | 0.0334248423292574 |
GO:0030890 | positive regulation of B cell proliferation | 0.0334248423292574 |
GO:0030054 | cell junction | 0.0363256029176708 |
GO:0030888 | regulation of B cell proliferation | 0.0363256029176708 |
GO:0045777 | positive regulation of blood pressure | 0.0363256029176708 |
GO:0042551 | neuron maturation | 0.0363256029176708 |
GO:0044271 | nitrogen compound biosynthetic process | 0.0364472693186944 |
GO:0009986 | cell surface | 0.0367267633936235 |
GO:0048869 | cellular developmental process | 0.0376508653115509 |
GO:0030154 | cell differentiation | 0.0376508653115509 |
GO:0007613 | memory | 0.0377188512022913 |
GO:0006586 | indolalkylamine metabolic process | 0.0377188512022913 |
GO:0042430 | indole and derivative metabolic process | 0.0377188512022913 |
GO:0042434 | indole derivative metabolic process | 0.0377188512022913 |
GO:0014070 | response to organic cyclic substance | 0.0377188512022913 |
GO:0019002 | GMP binding | 0.0377188512022913 |
GO:0030553 | cGMP binding | 0.0377188512022913 |
GO:0044425 | membrane part | 0.0389184376383538 |
GO:0008047 | enzyme activator activity | 0.0391494289481195 |
GO:0008015 | blood circulation | 0.0391494289481195 |
GO:0003013 | circulatory system process | 0.0391494289481195 |
GO:0033555 | multicellular organismal response to stress | 0.0391494289481195 |
GO:0051924 | regulation of calcium ion transport | 0.0391494289481195 |
GO:0030295 | protein kinase activator activity | 0.0391494289481195 |
GO:0003044 | regulation of systemic arterial blood pressure mediated by a chemical signal | 0.0391494289481195 |
GO:0016358 | dendrite development | 0.0391494289481195 |
GO:0046928 | regulation of neurotransmitter secretion | 0.0391494289481195 |
GO:0005249 | voltage-gated potassium channel activity | 0.0405178695451716 |
GO:0009628 | response to abiotic stimulus | 0.0405178695451716 |
GO:0004871 | signal transducer activity | 0.0405178695451716 |
GO:0060089 | molecular transducer activity | 0.0405178695451716 |
GO:0005217 | intracellular ligand-gated ion channel activity | 0.0412015630467243 |
GO:0005251 | delayed rectifier potassium channel activity | 0.0412015630467243 |
GO:0000902 | cell morphogenesis | 0.0417796366273478 |
GO:0032989 | cellular structure morphogenesis | 0.0417796366273478 |
GO:0006814 | sodium ion transport | 0.043033354197689 |
GO:0046658 | anchored to plasma membrane | 0.0435343717737452 |
GO:0044421 | extracellular region part | 0.0448842301609418 |
GO:0031225 | anchored to membrane | 0.0455746976718215 |
GO:0015926 | glucosidase activity | 0.0455746976718215 |
GO:0008171 | O-methyltransferase activity | 0.0455746976718215 |
GO:0004935 | adrenoceptor activity | 0.0455746976718215 |
GO:0006816 | calcium ion transport | 0.0463551620012127 |
GO:0003073 | regulation of systemic arterial blood pressure | 0.0473149728791188 |
GO:0051087 | chaperone binding | 0.0473149728791188 |
GO:0050804 | regulation of synaptic transmission | 0.0473149728791188 |
GO:0045444 | fat cell differentiation | 0.0473149728791188 |
GO:0042136 | neurotransmitter biosynthetic process | 0.0473149728791188 |
GO:0015630 | microtubule cytoskeleton | 0.0482960629280656 |
GO:0043269 | regulation of ion transport | 0.0493837226025986 |
GO:0005391 | sodium:potassium-exchanging ATPase activity | 0.0493837226025986 |
GO:0007612 | learning | 0.0493837226025986 |
GO:0005509 | calcium ion binding | 0.0496509577699423 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
pineal body | 1.05e-79 | 2 |
regional part of epithalamus | 1.05e-79 | 2 |
secretory circumventricular organ | 1.05e-79 | 2 |
circumventricular organ | 1.05e-79 | 2 |
epithalamus | 1.05e-79 | 2 |
gland of diencephalon | 1.48e-40 | 4 |
neuroendocrine gland | 1.48e-40 | 4 |
regional part of diencephalon | 1.48e-40 | 4 |
diencephalon | 1.02e-23 | 7 |
future diencephalon | 1.02e-23 | 7 |
meninx | 4.66e-21 | 2 |
membrane organ | 4.66e-21 | 2 |
meningeal cluster | 4.66e-21 | 2 |
locus ceruleus | 5.70e-21 | 2 |
brainstem nucleus | 5.70e-21 | 2 |
hindbrain nucleus | 5.70e-21 | 2 |
pons | 1.83e-14 | 3 |
adult organism | 2.58e-09 | 114 |
central nervous system | 2.54e-08 | 81 |
neural plate | 2.64e-08 | 82 |
presumptive neural plate | 2.64e-08 | 82 |
neurectoderm | 5.98e-08 | 86 |
brainstem | 6.78e-08 | 6 |
retina | 7.25e-08 | 6 |
photoreceptor array | 7.25e-08 | 6 |
posterior segment of eyeball | 7.25e-08 | 6 |
nervous system | 1.45e-07 | 89 |
regional part of nervous system | 2.03e-07 | 53 |
regional part of brain | 2.03e-07 | 53 |
neural tube | 4.58e-07 | 56 |
neural rod | 4.58e-07 | 56 |
future spinal cord | 4.58e-07 | 56 |
neural keel | 4.58e-07 | 56 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data