Coexpression cluster:C3822

Full id: C3822_CD14_Macrophage_mature_acute_Monocytederived_biphenotypic_granulocyte

Phase1 CAGE Peaks

Hg19::chr19:54876558..54876569,-	p4@LAIR1
Hg19::chr19:54876657..54876679,-	p5@LAIR1
Hg19::chr19:54876689..54876707,-	p6@LAIR1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	1.55e-56	108
common myeloid progenitor	1.55e-56	108
myeloid lineage restricted progenitor cell	1.91e-53	66
myeloid leukocyte	3.74e-52	72
granulocyte monocyte progenitor cell	1.77e-50	67
monopoietic cell	4.88e-50	59
monocyte	4.88e-50	59
monoblast	4.88e-50	59
promonocyte	4.88e-50	59
defensive cell	3.61e-48	48
phagocyte	3.61e-48	48
macrophage dendritic cell progenitor	1.25e-47	61
classical monocyte	6.59e-42	42
CD14-positive, CD16-negative classical monocyte	6.59e-42	42
hematopoietic stem cell	1.69e-40	168
angioblastic mesenchymal cell	1.69e-40	168
hematopoietic oligopotent progenitor cell	4.94e-38	161
hematopoietic multipotent progenitor cell	4.94e-38	161
hematopoietic cell	2.36e-37	177
leukocyte	4.11e-29	136
stuff accumulating cell	1.75e-28	87
hematopoietic lineage restricted progenitor cell	4.48e-28	120
nongranular leukocyte	8.01e-28	115
mesenchymal cell	1.99e-08	354
intermediate monocyte	7.20e-08	9
CD14-positive, CD16-positive monocyte	7.20e-08	9
connective tissue cell	1.02e-07	361
macrophage	1.63e-07	6

Uber Anatomy

Ontology term	p-value	n
bone marrow	5.32e-45	76
hematopoietic system	2.38e-44	98
blood island	2.38e-44	98
bone element	4.93e-41	82
hemolymphoid system	8.53e-40	108
immune system	1.11e-39	93
skeletal element	3.99e-35	90
skeletal system	3.84e-30	100
adult organism	1.73e-29	114
lateral plate mesoderm	7.48e-13	203
neural tube	2.57e-11	56
neural rod	2.57e-11	56
future spinal cord	2.57e-11	56
neural keel	2.57e-11	56
musculoskeletal system	3.61e-11	167
regional part of nervous system	8.83e-11	53
regional part of brain	8.83e-11	53
regional part of forebrain	4.59e-09	41
forebrain	4.59e-09	41
anterior neural tube	4.59e-09	41
future forebrain	4.59e-09	41
brain grey matter	8.38e-08	34
gray matter	8.38e-08	34
telencephalon	1.38e-07	34
connective tissue	3.72e-07	371
tissue	6.14e-07	773
regional part of telencephalon	6.50e-07	32
basal ganglion	7.29e-07	9
nuclear complex of neuraxis	7.29e-07	9
aggregate regional part of brain	7.29e-07	9
collection of basal ganglia	7.29e-07	9
cerebral subcortex	7.29e-07	9

Disease

Ontology term	p-value	n
leukemia	3.20e-11	39
myeloid leukemia	2.15e-10	31
hematologic cancer	3.28e-08	51
immune system cancer	3.28e-08	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.