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Coexpression cluster:C3757

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Full id: C3757_Melanocyte_optic_maxillary_pituitary_substantia_thalamus_medulla



Phase1 CAGE Peaks

Hg19::chr19:14945919..14945931,-p4@OR7A5
Hg19::chr19:14945933..14945972,-p2@OR7A5
Hg19::chr19:14945975..14946014,-p1@OR7A5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
melanocyte1.09e-1110
melanoblast1.09e-1110
pigment cell2.62e-0914
Uber Anatomy
Ontology termp-valuen
adult organism1.07e-55115
neural tube6.31e-5357
neural rod6.31e-5357
future spinal cord6.31e-5357
neural keel6.31e-5357
regional part of brain2.62e-4359
anterior neural tube1.11e-3942
central nervous system2.10e-3982
regional part of forebrain1.51e-3841
forebrain1.51e-3841
future forebrain1.51e-3841
brain6.85e-3869
future brain6.85e-3869
regional part of nervous system1.41e-3694
nervous system1.41e-3694
neural plate7.21e-3686
presumptive neural plate7.21e-3686
neurectoderm5.29e-3590
gray matter7.60e-3434
brain grey matter7.60e-3434
telencephalon1.52e-3334
regional part of telencephalon2.75e-3233
cerebral hemisphere1.54e-3032
pre-chordal neural plate6.51e-2761
regional part of cerebral cortex3.66e-2522
anterior region of body5.24e-23129
craniocervical region5.24e-23129
head6.43e-23123
neocortex2.12e-2220
cerebral cortex1.89e-2125
pallium1.89e-2125
ectoderm-derived structure3.38e-21169
ectoderm3.92e-21173
presumptive ectoderm3.92e-21173
nucleus of brain2.01e-149
neural nucleus2.01e-149
basal ganglion5.09e-149
nuclear complex of neuraxis5.09e-149
aggregate regional part of brain5.09e-149
collection of basal ganglia5.09e-149
cerebral subcortex5.09e-149
posterior neural tube6.74e-1415
chordal neural plate6.74e-1415
brainstem1.60e-138
segmental subdivision of nervous system1.71e-1113
telencephalic nucleus2.50e-117
segmental subdivision of hindbrain4.85e-1012
hindbrain4.85e-1012
presumptive hindbrain4.85e-1012
gyrus1.84e-096
temporal lobe5.42e-097
limbic system2.19e-085
tube5.94e-08194
organism subdivision6.94e-08365
occipital lobe1.10e-075
anatomical conduit3.77e-07241
organ part5.09e-07219


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.