MCL coexpression mm9:138
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0035235 | ionotropic glutamate receptor signaling pathway | 0.00111394947125536 |
GO:0007267 | cell-cell signaling | 0.00111394947125536 |
GO:0007268 | synaptic transmission | 0.00234198036627526 |
GO:0019226 | transmission of nerve impulse | 0.0027975133727282 |
GO:0007215 | glutamate signaling pathway | 0.0027975133727282 |
GO:0007632 | visual behavior | 0.0101992651112497 |
GO:0008542 | visual learning | 0.0101992651112497 |
GO:0007409 | axonogenesis | 0.0116576548436933 |
GO:0048667 | neuron morphogenesis during differentiation | 0.0116576548436933 |
GO:0048812 | neurite morphogenesis | 0.0116576548436933 |
GO:0010324 | membrane invagination | 0.0116576548436933 |
GO:0006897 | endocytosis | 0.0116576548436933 |
GO:0009628 | response to abiotic stimulus | 0.0116576548436933 |
GO:0000904 | cellular morphogenesis during differentiation | 0.0116576548436933 |
GO:0031175 | neurite development | 0.0116576548436933 |
GO:0008344 | adult locomotory behavior | 0.0116576548436933 |
GO:0048878 | chemical homeostasis | 0.0116576548436933 |
GO:0048666 | neuron development | 0.0116576548436933 |
GO:0044430 | cytoskeletal part | 0.0116576548436933 |
GO:0007612 | learning | 0.0116576548436933 |
GO:0040014 | regulation of multicellular organism growth | 0.0116576548436933 |
GO:0051428 | peptide hormone receptor binding | 0.0116576548436933 |
GO:0048790 | maintenance of presynaptic active zone structure | 0.0116576548436933 |
GO:0051602 | response to electrical stimulus | 0.0116576548436933 |
GO:0031629 | synaptic vesicle fusion to presynaptic membrane | 0.0116576548436933 |
GO:0051462 | regulation of cortisol secretion | 0.0116576548436933 |
GO:0031338 | regulation of vesicle fusion | 0.0116576548436933 |
GO:0051463 | negative regulation of cortisol secretion | 0.0116576548436933 |
GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane | 0.0116576548436933 |
GO:0051233 | spindle midzone | 0.0116576548436933 |
GO:0043400 | cortisol secretion | 0.0116576548436933 |
GO:0060125 | negative regulation of growth hormone secretion | 0.0116576548436933 |
GO:0050975 | sensory perception of touch | 0.0116576548436933 |
GO:0048669 | collateral sprouting in the absence of injury | 0.0116576548436933 |
GO:0016044 | membrane organization and biogenesis | 0.0116576548436933 |
GO:0008021 | synaptic vesicle | 0.0116576548436933 |
GO:0006874 | cellular calcium ion homeostasis | 0.0138041655180267 |
GO:0055074 | calcium ion homeostasis | 0.0138041655180267 |
GO:0030534 | adult behavior | 0.0138041655180267 |
GO:0035264 | multicellular organism growth | 0.0138041655180267 |
GO:0006810 | transport | 0.0138041655180267 |
GO:0032990 | cell part morphogenesis | 0.0138041655180267 |
GO:0048858 | cell projection morphogenesis | 0.0138041655180267 |
GO:0030030 | cell projection organization and biogenesis | 0.0138041655180267 |
GO:0006875 | cellular metal ion homeostasis | 0.0138041655180267 |
GO:0051234 | establishment of localization | 0.0138041655180267 |
GO:0030182 | neuron differentiation | 0.0138041655180267 |
GO:0055065 | metal ion homeostasis | 0.0138041655180267 |
GO:0007611 | learning and/or memory | 0.0138041655180267 |
GO:0015630 | microtubule cytoskeleton | 0.0138041655180267 |
GO:0031410 | cytoplasmic vesicle | 0.0138041655180267 |
GO:0009416 | response to light stimulus | 0.0138041655180267 |
GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 0.0138041655180267 |
GO:0016199 | axon midline choice point recognition | 0.0138041655180267 |
GO:0046825 | regulation of protein export from nucleus | 0.0138041655180267 |
GO:0051563 | smooth endoplasmic reticulum calcium ion homeostasis | 0.0138041655180267 |
GO:0051319 | G2 phase | 0.0138041655180267 |
GO:0000085 | G2 phase of mitotic cell cycle | 0.0138041655180267 |
GO:0030136 | clathrin-coated vesicle | 0.0138041655180267 |
GO:0031982 | vesicle | 0.0138460913315066 |
GO:0048699 | generation of neurons | 0.016113704388195 |
GO:0051049 | regulation of transport | 0.0168738222448918 |
GO:0042592 | homeostatic process | 0.0169071157587907 |
GO:0003001 | generation of a signal involved in cell-cell signaling | 0.017247822072276 |
GO:0030135 | coated vesicle | 0.017247822072276 |
GO:0001505 | regulation of neurotransmitter levels | 0.0173732855766031 |
GO:0022008 | neurogenesis | 0.0179311845349454 |
GO:0048668 | collateral sprouting | 0.0179325221783552 |
GO:0009314 | response to radiation | 0.0185274641007596 |
GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.0190430221587785 |
GO:0051179 | localization | 0.0191483259823631 |
GO:0050954 | sensory perception of mechanical stimulus | 0.0191483259823631 |
GO:0005737 | cytoplasm | 0.0191483259823631 |
GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0191483259823631 |
GO:0030003 | cellular cation homeostasis | 0.0195814285200309 |
GO:0006906 | vesicle fusion | 0.0195814285200309 |
GO:0051124 | synaptic growth at neuromuscular junction | 0.0195814285200309 |
GO:0016198 | axon choice point recognition | 0.0195814285200309 |
GO:0060123 | regulation of growth hormone secretion | 0.0195814285200309 |
GO:0046676 | negative regulation of insulin secretion | 0.0195814285200309 |
GO:0016322 | neuron remodeling | 0.0195814285200309 |
GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity | 0.0195814285200309 |
GO:0045931 | positive regulation of progression through mitotic cell cycle | 0.0195814285200309 |
GO:0055080 | cation homeostasis | 0.0200411252627956 |
GO:0016192 | vesicle-mediated transport | 0.022909331631087 |
GO:0003016 | respiratory system process | 0.0230772076637092 |
GO:0046887 | positive regulation of hormone secretion | 0.0230772076637092 |
GO:0016188 | synaptic vesicle maturation | 0.0230772076637092 |
GO:0005856 | cytoskeleton | 0.0243833862298391 |
GO:0030252 | growth hormone secretion | 0.0265545073997606 |
GO:0048011 | nerve growth factor receptor signaling pathway | 0.0265545073997606 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.0265545073997606 |
GO:0043228 | non-membrane-bound organelle | 0.0265545073997606 |
GO:0003924 | GTPase activity | 0.0273138125323779 |
GO:0017111 | nucleoside-triphosphatase activity | 0.0273138125323779 |
GO:0005624 | membrane fraction | 0.0273138125323779 |
GO:0001967 | suckling behavior | 0.0288645494470792 |
GO:0032989 | cellular structure morphogenesis | 0.0288645494470792 |
GO:0000902 | cell morphogenesis | 0.0288645494470792 |
GO:0016462 | pyrophosphatase activity | 0.0295048682068776 |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0295048682068776 |
GO:0006873 | cellular ion homeostasis | 0.0295048682068776 |
GO:0055082 | cellular chemical homeostasis | 0.0295048682068776 |
GO:0016817 | hydrolase activity, acting on acid anhydrides | 0.0295048682068776 |
GO:0040008 | regulation of growth | 0.0295048682068776 |
GO:0006378 | mRNA polyadenylation | 0.0295048682068776 |
GO:0009755 | hormone-mediated signaling | 0.0295048682068776 |
GO:0046888 | negative regulation of hormone secretion | 0.0295048682068776 |
GO:0048488 | synaptic vesicle endocytosis | 0.0295048682068776 |
GO:0006878 | cellular copper ion homeostasis | 0.0295048682068776 |
GO:0044444 | cytoplasmic part | 0.0302245016017736 |
GO:0000267 | cell fraction | 0.031435029463894 |
GO:0035253 | ciliary rootlet | 0.0314640346506138 |
GO:0055070 | copper ion homeostasis | 0.0314640346506138 |
GO:0007617 | mating behavior | 0.0314640346506138 |
GO:0042551 | neuron maturation | 0.0314640346506138 |
GO:0050801 | ion homeostasis | 0.0335025643965554 |
GO:0005391 | sodium:potassium-exchanging ATPase activity | 0.0335025643965554 |
GO:0051047 | positive regulation of secretion | 0.0335025643965554 |
GO:0008088 | axon cargo transport | 0.0335025643965554 |
GO:0006611 | protein export from nucleus | 0.0335025643965554 |
GO:0051223 | regulation of protein transport | 0.0356598603309848 |
GO:0016079 | synaptic vesicle exocytosis | 0.0356598603309848 |
GO:0043631 | RNA polyadenylation | 0.0356598603309848 |
GO:0050796 | regulation of insulin secretion | 0.0356598603309848 |
GO:0000074 | regulation of progression through cell cycle | 0.0358862668556828 |
GO:0050877 | neurological system process | 0.0360720793774721 |
GO:0016050 | vesicle organization and biogenesis | 0.0362749626013154 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0362749626013154 |
GO:0051048 | negative regulation of secretion | 0.0362749626013154 |
GO:0045787 | positive regulation of progression through cell cycle | 0.0362749626013154 |
GO:0051427 | hormone receptor binding | 0.0362749626013154 |
GO:0035265 | organ growth | 0.0362749626013154 |
GO:0008038 | neuron recognition | 0.0362749626013154 |
GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0368193715543754 |
GO:0046907 | intracellular transport | 0.037543017046726 |
GO:0005874 | microtubule | 0.0375992703884459 |
GO:0031594 | neuromuscular junction | 0.0375992703884459 |
GO:0007274 | neuromuscular synaptic transmission | 0.0375992703884459 |
GO:0007618 | mating | 0.0375992703884459 |
GO:0031988 | membrane-bound vesicle | 0.0378230800137175 |
GO:0031124 | mRNA 3'-end processing | 0.0390802852374933 |
GO:0005843 | cytosolic small ribosomal subunit (sensu Eukaryota) | 0.0390802852374933 |
GO:0044441 | cilium part | 0.0390802852374933 |
GO:0019098 | reproductive behavior | 0.0390802852374933 |
GO:0007626 | locomotory behavior | 0.0394609606910202 |
GO:0022414 | reproductive process | 0.0406869366672434 |
GO:0065008 | regulation of biological quality | 0.0418663760645604 |
GO:0019725 | cellular homeostasis | 0.0420184018344276 |
GO:0003008 | system process | 0.0423956247907445 |
GO:0007399 | nervous system development | 0.0425041037872437 |
GO:0009725 | response to hormone stimulus | 0.0425736919022379 |
GO:0007613 | memory | 0.0443420510603472 |
GO:0000077 | DNA damage checkpoint | 0.0443420510603472 |
GO:0031123 | RNA 3'-end processing | 0.0443420510603472 |
GO:0007416 | synaptogenesis | 0.0463345616556885 |
GO:0017157 | regulation of exocytosis | 0.0463345616556885 |
GO:0006641 | triacylglycerol metabolic process | 0.0482750074580333 |
GO:0001725 | stress fiber | 0.0482750074580333 |
GO:0031570 | DNA integrity checkpoint | 0.0489492009198897 |
GO:0007528 | neuromuscular junction development | 0.0489492009198897 |
GO:0032432 | actin filament bundle | 0.0489492009198897 |
GO:0046883 | regulation of hormone secretion | 0.0489492009198897 |
GO:0007346 | regulation of progression through mitotic cell cycle | 0.0489492009198897 |
GO:0042417 | dopamine metabolic process | 0.0489492009198897 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
CNS neuron (sensu Vertebrata) | 6.23e-21 | 23 |
neuroblast (sensu Vertebrata) | 6.23e-21 | 23 |
neuron | 8.61e-14 | 33 |
neuronal stem cell | 8.61e-14 | 33 |
neuroblast | 8.61e-14 | 33 |
electrically signaling cell | 8.61e-14 | 33 |
electrically responsive cell | 1.14e-10 | 39 |
electrically active cell | 1.14e-10 | 39 |
neural cell | 5.47e-10 | 43 |
ectodermal cell | 1.29e-09 | 44 |
neurectodermal cell | 1.29e-09 | 44 |
non-terminally differentiated cell | 5.42e-08 | 49 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 6.94311e-12 |
MA0004.1 | 0.0220952 |
MA0006.1 | 0.0471954 |
MA0007.1 | 0.136841 |
MA0009.1 | 0.109275 |
MA0014.1 | 1.03414e-09 |
MA0017.1 | 0.508864 |
MA0019.1 | 0.0421173 |
MA0024.1 | 0.0899821 |
MA0025.1 | 0.241615 |
MA0027.1 | 1.50773 |
MA0028.1 | 0.611804 |
MA0029.1 | 0.58293 |
MA0030.1 | 0.0837529 |
MA0031.1 | 0.0700796 |
MA0038.1 | 0.0183031 |
MA0040.1 | 0.368817 |
MA0041.1 | 0.607066 |
MA0042.1 | 1.61361 |
MA0043.1 | 0.15848 |
MA0046.1 | 0.398327 |
MA0048.1 | 3.4813e-05 |
MA0050.1 | 1.52135 |
MA0051.1 | 0.690467 |
MA0052.1 | 0.760902 |
MA0055.1 | 0.000166309 |
MA0056.1 | 0 |
MA0057.1 | 0.00232185 |
MA0058.1 | 0.0585027 |
MA0059.1 | 0.794682 |
MA0060.1 | 0.000839638 |
MA0061.1 | 0.0190577 |
MA0063.1 | 0 |
MA0066.1 | 0.938963 |
MA0067.1 | 0.319057 |
MA0068.1 | 0.00279809 |
MA0069.1 | 0.119167 |
MA0070.1 | 0.367208 |
MA0071.1 | 0.852277 |
MA0072.1 | 0.722709 |
MA0073.1 | 1.29337e-09 |
MA0074.1 | 0.527234 |
MA0076.1 | 0.0404451 |
MA0077.1 | 0.330629 |
MA0078.1 | 0.109295 |
MA0081.1 | 4.04522 |
MA0083.1 | 0.477845 |
MA0084.1 | 0.583888 |
MA0087.1 | 0.135069 |
MA0088.1 | 0.000227565 |
MA0089.1 | 0 |
MA0090.1 | 0.114576 |
MA0091.1 | 0.746763 |
MA0092.1 | 1.72879 |
MA0093.1 | 0.00904163 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0521274 |
MA0101.1 | 0.00820137 |
MA0103.1 | 0.0801774 |
MA0105.1 | 0.140484 |
MA0106.1 | 0.0274303 |
MA0107.1 | 0.367441 |
MA0108.2 | 0.0486077 |
MA0109.1 | 0 |
MA0111.1 | 0.24726 |
MA0113.1 | 0.0956638 |
MA0114.1 | 0.218283 |
MA0115.1 | 0.160031 |
MA0116.1 | 0.167359 |
MA0117.1 | 0.142573 |
MA0119.1 | 0.0298859 |
MA0122.1 | 0.908754 |
MA0124.1 | 0.768602 |
MA0125.1 | 0.231 |
MA0130.1 | 0 |
MA0131.1 | 0.0408933 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 2.29011 |
MA0136.1 | 0.0673904 |
MA0139.1 | 0.408824 |
MA0140.1 | 0.756943 |
MA0141.1 | 0.187415 |
MA0142.1 | 0.858979 |
MA0143.1 | 3.08644 |
MA0144.1 | 0.0193532 |
MA0145.1 | 3.8076e-05 |
MA0146.1 | 6.43787e-07 |
MA0147.1 | 0.0027373 |
MA0148.1 | 0.323098 |
MA0149.1 | 0.0801168 |
MA0062.2 | 0.00332083 |
MA0035.2 | 0.7743 |
MA0039.2 | 3.18228e-15 |
MA0138.2 | 0.631145 |
MA0002.2 | 0.088712 |
MA0137.2 | 0.181869 |
MA0104.2 | 8.83929e-05 |
MA0047.2 | 0.402098 |
MA0112.2 | 0.0106814 |
MA0065.2 | 0.0197903 |
MA0150.1 | 0.0184717 |
MA0151.1 | 0 |
MA0152.1 | 0.208525 |
MA0153.1 | 0.553521 |
MA0154.1 | 0.178255 |
MA0155.1 | 0.178521 |
MA0156.1 | 0.0035132 |
MA0157.1 | 0.05421 |
MA0158.1 | 0 |
MA0159.1 | 0.19486 |
MA0160.1 | 0.329816 |
MA0161.1 | 0 |
MA0162.1 | 3.78714e-10 |
MA0163.1 | 7.58919e-05 |
MA0164.1 | 0.349738 |
MA0080.2 | 0.95554 |
MA0018.2 | 0.0157357 |
MA0099.2 | 0.963244 |
MA0079.2 | 0 |
MA0102.2 | 0.62983 |
MA0258.1 | 0.529854 |
MA0259.1 | 0.0199899 |
MA0442.1 | 0 |