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Coexpression cluster:C2133

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Full id: C2133_Mesenchymal_Fibroblast_Smooth_osteoclastoma_Osteoblast_Prostate_leiomyoma



Phase1 CAGE Peaks

  Short description
Hg19::chr11:46299186..46299195,+ p3@CREB3L1
Hg19::chr11:46299199..46299233,+ p1@CREB3L1
Hg19::chr11:46299443..46299459,+ p4@CREB3L1
Hg19::chr11:46299539..46299620,+ p2@CREB3L1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
dense mesenchyme tissue1.66e-2573
somite3.49e-2571
presomitic mesoderm3.49e-2571
presumptive segmental plate3.49e-2571
dermomyotome3.49e-2571
trunk paraxial mesoderm3.49e-2571
paraxial mesoderm7.42e-2572
presumptive paraxial mesoderm7.42e-2572
epithelial vesicle7.85e-2478
skeletal muscle tissue8.90e-2362
striated muscle tissue8.90e-2362
myotome8.90e-2362
muscle tissue1.05e-2264
musculature1.05e-2264
musculature of body1.05e-2264
multilaminar epithelium1.28e-2083
mesenchyme1.98e-20160
entire embryonic mesenchyme1.98e-20160
trunk mesenchyme4.91e-20122
unilaminar epithelium3.98e-14148
splanchnic layer of lateral plate mesoderm7.39e-1383
multi-tissue structure1.07e-12342
organism subdivision1.16e-12264
artery7.50e-1242
arterial blood vessel7.50e-1242
arterial system7.50e-1242
trunk1.53e-10199
systemic artery1.94e-1033
systemic arterial system1.94e-1033
vasculature2.95e-1078
vascular system2.95e-1078
surface structure1.83e-0999
epithelial tube open at both ends8.50e-0959
blood vessel8.50e-0959
blood vasculature8.50e-0959
vascular cord8.50e-0959
multi-cellular organism9.33e-09656
cell layer9.42e-09309
epithelium2.04e-08306
epithelial tube5.83e-08117
integument6.54e-0846
integumental system6.54e-0846
vessel1.70e-0768
smooth muscle tissue3.61e-0715
cardiovascular system5.18e-07109
circulatory system5.59e-07112
skin of body7.28e-0741


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.39007
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.11.91805
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.214613
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.11.4709
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.01976
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.92815
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.23.07509
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.15942
MA0163.12.49771
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.23.12283
MA0102.21.75932
MA0258.10.418966
MA0259.12.06681
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
HEY1#2346244.040111043105710.00375304636917980.0185536499929362
IRF1#365935.727872815172930.008097114790333330.0319827000335699
JUND#372746.994663941871030.000417684217818580.00391022965442405
POU2F2#545249.106124057742520.000145395665174930.00188049261612439
SIN3A#2594245.408884726815140.001168172384885160.00794237065978913
TCF12#6938410.63446490218647.8163066689251e-050.00119871843200568



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.