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Coexpression cluster:C3668

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Full id: C3668_Mallassezderived_Prostate_Urothelial_Bronchial_Gingival_Small_Esophageal



Phase1 CAGE Peaks

  Short description
Hg19::chr17:6544328..6544342,+ p2@TXNDC17
Hg19::chr17:6544356..6544363,+ p3@TXNDC17
Hg19::chr17:6544372..6544386,+ p1@TXNDC17


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
epithelial vesicle1.59e-1278
multilaminar epithelium4.72e-1283
organism subdivision9.38e-12264
trunk1.08e-11199
unilaminar epithelium1.09e-10148
mesenchyme4.28e-10160
entire embryonic mesenchyme4.28e-10160
somite4.37e-1071
presomitic mesoderm4.37e-1071
presumptive segmental plate4.37e-1071
dermomyotome4.37e-1071
trunk paraxial mesoderm4.37e-1071
trunk mesenchyme5.22e-10122
epithelial tube8.84e-10117
dense mesenchyme tissue1.30e-0973
paraxial mesoderm1.64e-0972
presumptive paraxial mesoderm1.64e-0972
skeletal muscle tissue1.69e-0862
striated muscle tissue1.69e-0862
myotome1.69e-0862
muscle tissue6.23e-0864
musculature6.23e-0864
musculature of body6.23e-0864
vasculature7.22e-0878
vascular system7.22e-0878
artery4.03e-0742
arterial blood vessel4.03e-0742
arterial system4.03e-0742


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.12.26702
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.12.67616
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.12.91768
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.22.96208
MA0035.20.894194
MA0039.21.62945
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.13.52796
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189863843763412
E2F1#186934.907389214879320.008460985347239390.0324981372027632
E2F6#187635.017155731697390.00791769806886330.0321782422217299
EGR1#195834.988179094810140.008056488137383440.03203180921959
ELF1#199734.258097958807540.01295179875054610.0461757666999482
ELK4#2005316.2356816584680.0002336043955745990.00255604080350084
ETS1#211339.728760922202340.001085840092584840.00761612178841288
FOSL2#2355316.93020060456170.0002060162053171620.00242818265061721
GABPB1#255337.067683836182170.002832212825417420.0153970889216475
IRF1#365937.63716375356390.002244692747297240.0127951897082729
MAX#414936.452555509007120.003721913834265510.0186352633844794
MXI1#460139.96157162875930.001011470541259020.00719695952163449
MYC#460935.22228187160940.007020843755740150.0294206115237229
NFKB1#479035.488063424193840.006049381815655430.0269386171255378
NR3C1#2908314.9730233311730.0002978331194675480.00308646489026308
PAX5#507936.669565531177830.003370290999677260.0172789662616118
POU2F2#545239.106124057742520.001324165192682130.00881642793309505
REST#597839.650028716128020.001112636247114590.00766862119794104
SIN3A#2594235.408884726815140.006318961977991520.0276394048674229
SIX5#147912317.0867153554590.0002004060546325010.00239530875941449
SP1#666735.69838137814090.005403962701712170.0246251782627565
SPI1#668838.204323508522730.001810593189410520.0109001926509595
SREBF1#6720347.00584944048839.62099323994382e-060.000254574844942106
SRF#6722313.79717826216780.0003806615025800190.00374737549891174
STAT1#6772320.70658749719920.0001125992441046670.00154753947296319
TAF7#6879311.43306940492390.0006690181981945830.00542312881102484
TCF12#6938310.63446490218640.0008313523990202070.006288976763818
TCF7L2#6934310.77017656313730.0008003181298398380.00613058714701063
USF1#739136.361499277207960.00388404057290560.0190095746470635
YY1#752834.911170749853860.008441455341808260.032898617599937
ZBTB7A#5134137.35190930787590.002516255860282270.0140030503432631
ZNF263#1012738.221841637010680.001799043925565870.0109321201223119



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.