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Coexpression cluster:C4791

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Full id: C4791_schwannoma_CD14_mesenchymal_Mast_Fibroblast_Mesothelial_Macrophage



Phase1 CAGE Peaks

  Short description
Hg19::chr9:115950730..115950743,+ p@chr9:115950730..115950743
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Hg19::chr9:115950749..115950771,+ p@chr9:115950749..115950771
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Hg19::chr9:115950788..115950806,+ p@chr9:115950788..115950806
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Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
defensive cell1.48e-5648
phagocyte1.48e-5648
classical monocyte5.76e-5442
CD14-positive, CD16-negative classical monocyte5.76e-5442
myeloid lineage restricted progenitor cell3.19e-5066
granulocyte monocyte progenitor cell3.23e-4967
myeloid leukocyte7.93e-4972
monopoietic cell2.27e-4859
monocyte2.27e-4859
monoblast2.27e-4859
promonocyte2.27e-4859
macrophage dendritic cell progenitor2.88e-4661
stuff accumulating cell4.42e-3187
myeloid cell6.65e-28108
common myeloid progenitor6.65e-28108
mesenchymal cell1.49e-20354
hematopoietic lineage restricted progenitor cell3.50e-20120
connective tissue cell1.33e-19361
leukocyte9.54e-19136
motile cell1.58e-18386
nongranular leukocyte2.39e-18115
multi fate stem cell7.70e-17427
somatic stem cell3.40e-16433
stem cell2.30e-15441
hematopoietic oligopotent progenitor cell2.29e-13161
hematopoietic multipotent progenitor cell2.29e-13161
hematopoietic stem cell7.73e-13168
angioblastic mesenchymal cell7.73e-13168
hematopoietic cell2.02e-11177
animal cell7.29e-11679
eukaryotic cell7.29e-11679
mesothelial cell6.78e-1019
intermediate monocyte7.86e-099
CD14-positive, CD16-positive monocyte7.86e-099
somatic cell1.09e-08588
native cell4.18e-08722
Uber Anatomy
Ontology termp-valuen
bone marrow1.24e-4576
bone element5.32e-4182
skeletal element5.42e-3990
skeletal system4.16e-36100
immune system1.27e-3593
hematopoietic system8.20e-3398
blood island8.20e-3398
hemolymphoid system1.81e-29108
musculoskeletal system3.63e-20167
connective tissue2.62e-18371
lateral plate mesoderm2.66e-12203
mesoderm2.06e-11315
mesoderm-derived structure2.06e-11315
presumptive mesoderm2.06e-11315
right ovary1.50e-075
Disease
Ontology termp-valuen
ovarian cancer4.05e-1114


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.12.0778
MA0072.14.64819
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.23.08747
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.12.02335
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235338.99795530889440.001372499272417130.00902432960916473
GATA2#2624312.7449317335540.0004829527704283790.00439288489729747
JUN#3725312.51282919233630.0005103313992726250.00446573112766097
JUND#372736.994663941871030.002921845042734990.0157776006627475
STAT3#6774310.51946499715420.0008589184530415310.00646100434436794



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.