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Coexpression cluster:C1776

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Full id: C1776_embryonic_CD8_Natural_Whole_NK_blood_Basophils



Phase1 CAGE Peaks

Hg19::chr17:34199262..34199274,-p@chr17:34199262..34199274
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Hg19::chr17:34199297..34199315,-p@chr17:34199297..34199315
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Hg19::chr17:34205568..34205579,-p@chr17:34205568..34205579
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Hg19::chr17:34205625..34205636,-p@chr17:34205625..34205636
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Hg19::chr17:34207354..34207372,-p1@CCL5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
nongranular leukocyte1.02e-29115
leukocyte4.32e-29136
hematopoietic cell4.83e-28177
hematopoietic stem cell1.13e-27168
angioblastic mesenchymal cell1.13e-27168
hematopoietic oligopotent progenitor cell1.41e-26161
hematopoietic multipotent progenitor cell1.41e-26161
hematopoietic lineage restricted progenitor cell7.10e-25120
mature alpha-beta T cell1.22e-1718
alpha-beta T cell1.22e-1718
immature T cell1.22e-1718
mature T cell1.22e-1718
immature alpha-beta T cell1.22e-1718
defensive cell5.39e-1648
phagocyte5.39e-1648
CD8-positive, alpha-beta T cell6.43e-1611
classical monocyte2.49e-1542
CD14-positive, CD16-negative classical monocyte2.49e-1542
myeloid leukocyte3.31e-1572
macrophage dendritic cell progenitor5.53e-1561
monopoietic cell7.54e-1559
monocyte7.54e-1559
monoblast7.54e-1559
promonocyte7.54e-1559
myeloid cell3.66e-14108
common myeloid progenitor3.66e-14108
lymphoid lineage restricted progenitor cell8.47e-1352
T cell9.17e-1325
pro-T cell9.17e-1325
granulocyte monocyte progenitor cell1.02e-1267
lymphocyte2.18e-1253
common lymphoid progenitor2.18e-1253
myeloid lineage restricted progenitor cell3.28e-1266
nucleate cell1.29e-1155
circulating cell3.97e-086
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.18e-2498
blood island1.18e-2498
hemolymphoid system6.60e-24108
blood2.78e-1915
haemolymphatic fluid2.78e-1915
organism substance2.78e-1915
immune system1.79e-1293
bone marrow9.73e-1176
larynx7.13e-109
bone element3.06e-0982
lateral plate mesoderm1.02e-08203
upper respiratory tract9.86e-0819
skeletal element1.35e-0790
skeletal system5.78e-07100


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.