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Coexpression cluster:C1875

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Full id: C1875_migratory_CD14_CD14CD16_CD4_Basophils_NK_acute



Phase1 CAGE Peaks

  Short description
Hg19::chr21:15918672..15918683,- p2@SAMSN1
Hg19::chr3:84892515..84892517,+ p@chr3:84892515..84892517
+
Hg19::chr7:45016548..45016567,- p5@MYO1G
Hg19::chr7:45018571..45018589,- p3@MYO1G
Hg19::chr7:45018602..45018625,- p1@MYO1G


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0001784phosphotyrosine binding0.00459167901859403
GO:0045309protein phosphorylated amino acid binding0.00459167901859403
GO:0051219phosphoprotein binding0.00510156518817511
GO:0016459myosin complex0.0408816032450061



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
hematopoietic stem cell4.71e-97168
angioblastic mesenchymal cell4.71e-97168
hematopoietic cell1.40e-93177
hematopoietic oligopotent progenitor cell2.38e-93161
hematopoietic multipotent progenitor cell2.38e-93161
leukocyte1.38e-86136
hematopoietic lineage restricted progenitor cell3.50e-72120
nongranular leukocyte3.87e-72115
myeloid cell5.24e-58108
common myeloid progenitor5.24e-58108
myeloid leukocyte7.41e-4672
granulocyte monocyte progenitor cell1.07e-4167
defensive cell5.63e-4148
phagocyte5.63e-4148
classical monocyte1.25e-4042
CD14-positive, CD16-negative classical monocyte1.25e-4042
macrophage dendritic cell progenitor3.33e-3961
myeloid lineage restricted progenitor cell5.71e-3966
monopoietic cell8.71e-3859
monocyte8.71e-3859
monoblast8.71e-3859
promonocyte8.71e-3859
lymphocyte2.60e-2953
common lymphoid progenitor2.60e-2953
lymphoid lineage restricted progenitor cell7.33e-2952
nucleate cell1.20e-2855
mesenchymal cell6.52e-20354
connective tissue cell1.27e-18361
T cell5.24e-1725
pro-T cell5.24e-1725
motile cell3.28e-14386
stuff accumulating cell7.69e-1487
mature alpha-beta T cell8.32e-1418
alpha-beta T cell8.32e-1418
immature T cell8.32e-1418
mature T cell8.32e-1418
immature alpha-beta T cell8.32e-1418
lymphocyte of B lineage1.59e-1124
pro-B cell1.59e-1124
multi fate stem cell8.83e-10427
stem cell2.60e-09441
somatic stem cell4.16e-09433
CD8-positive, alpha-beta T cell4.51e-0911
intermediate monocyte5.83e-099
CD14-positive, CD16-positive monocyte5.83e-099
B cell3.14e-0814
dendritic cell3.20e-0810
conventional dendritic cell1.50e-078
granulocyte3.35e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system6.16e-5098
blood island6.16e-5098
hemolymphoid system1.32e-44108
bone marrow4.43e-3576
immune system1.70e-3493
bone element1.08e-3082
skeletal element8.23e-2690
skeletal system1.16e-21100
connective tissue2.74e-17371
lateral plate mesoderm3.17e-13203
blood5.76e-1115
haemolymphatic fluid5.76e-1115
organism substance5.76e-1115
Disease
Ontology termp-valuen
hematologic cancer9.91e-1251
immune system cancer9.91e-1251
leukemia2.49e-1039
myeloid leukemia7.61e-0831


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.136928
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.11.48918
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.11.05691
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.12.2047
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.362215
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.14.1136
MA0084.11.62584
MA0087.11.07867
MA0088.11.3271
MA0089.10
MA0090.11.36977
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.12.26263
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.868598
MA0146.10.6031
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.311551
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.823998
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335211.34778204144280.01157056933741320.0422923281080075
BCLAF1#9774312.99158856607310.0009178032402542550.00667696103433506
EBF1#187935.34388010794140.01187615563868110.043239805429605
IRF4#3662313.14870761204650.0008860469322808430.00660512887655096
POU2F2#545235.463674434645510.01115650094469780.0410214688833717



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.