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Coexpression cluster:C2072

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Full id: C2072_Osteoblast_CD14_Adipocyte_leiomyoma_Prostate_Smooth_Fibroblast



Phase1 CAGE Peaks

Hg19::chr10:74034624..74034637,+p12@DDIT4
Hg19::chr1:26607773..26607792,+p@chr1:26607773..26607792
+
Hg19::chr6:36653890..36653913,+p@chr6:36653890..36653913
+
Hg19::chr6:36654379..36654413,+p@chr6:36654379..36654413
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
somatic cell5.65e-21588
classical monocyte5.04e-1642
CD14-positive, CD16-negative classical monocyte5.04e-1642
stuff accumulating cell1.20e-1587
defensive cell2.93e-1448
phagocyte2.93e-1448
somatic stem cell1.11e-12433
multi fate stem cell1.21e-12427
stem cell5.97e-12441
myeloid lineage restricted progenitor cell1.44e-1166
granulocyte monocyte progenitor cell1.88e-1167
monopoietic cell2.13e-1159
monocyte2.13e-1159
monoblast2.13e-1159
promonocyte2.13e-1159
animal cell2.16e-11679
eukaryotic cell2.16e-11679
macrophage dendritic cell progenitor3.70e-1161
myeloid leukocyte8.01e-1172
contractile cell1.73e-0859
muscle precursor cell5.22e-0858
myoblast5.22e-0858
multi-potent skeletal muscle stem cell5.22e-0858
smooth muscle cell6.17e-0843
smooth muscle myoblast6.17e-0843
muscle cell1.53e-0755
connective tissue cell6.50e-07361
Uber Anatomy
Ontology termp-valuen
mesoderm7.27e-20315
mesoderm-derived structure7.27e-20315
presumptive mesoderm7.27e-20315
musculoskeletal system3.36e-16167
lateral plate mesoderm4.57e-15203
bone marrow4.31e-1176
skeletal element3.32e-1090
skeletal system3.61e-10100
immune system1.19e-0993
bone element2.59e-0982
multilaminar epithelium5.85e-0983
epithelial vesicle1.10e-0778
artery1.68e-0742
arterial blood vessel1.68e-0742
arterial system1.68e-0742
hemolymphoid system2.16e-07108
hematopoietic system3.40e-0798
blood island3.40e-0798
dense mesenchyme tissue4.01e-0773
somite4.51e-0771
presomitic mesoderm4.51e-0771
presumptive segmental plate4.51e-0771
dermomyotome4.51e-0771
trunk paraxial mesoderm4.51e-0771
embryonic structure5.22e-07564
multi-cellular organism6.29e-07656
skeletal muscle tissue6.39e-0762
striated muscle tissue6.39e-0762
myotome6.39e-0762
paraxial mesoderm9.05e-0772
presumptive paraxial mesoderm9.05e-0772
germ layer9.55e-07560
germ layer / neural crest9.55e-07560
embryonic tissue9.55e-07560
presumptive structure9.55e-07560
germ layer / neural crest derived structure9.55e-07560
epiblast (generic)9.55e-07560
muscle tissue9.82e-0764
musculature9.82e-0764
musculature of body9.82e-0764


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.13.20189
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.214613
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.21.65877
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.918944
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.20937
MA0102.21.75932
MA0258.11.88931
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.