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Coexpression cluster:C4476

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Full id: C4476_Chondrocyte_Preadipocyte_Adipocyte_myxofibrosarcoma_Osteoblast_Fibroblast_occipital



Phase1 CAGE Peaks

  Short description
Hg19::chr5:14871734..14871751,- p3@ANKH
Hg19::chr5:14871759..14871775,- p7@ANKH
Hg19::chr5:14871789..14871813,- p6@ANKH


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
preadipocyte1.59e-0712
Uber Anatomy
Ontology termp-valuen
adult organism8.41e-21114
neural tube4.78e-1956
neural rod4.78e-1956
future spinal cord4.78e-1956
neural keel4.78e-1956
brain3.33e-1868
future brain3.33e-1868
regional part of nervous system3.82e-1853
regional part of brain3.82e-1853
central nervous system1.44e-1681
neural plate3.72e-1682
presumptive neural plate3.72e-1682
regional part of forebrain5.64e-1641
forebrain5.64e-1641
anterior neural tube5.64e-1641
future forebrain5.64e-1641
nervous system1.02e-1589
neurectoderm1.04e-1486
telencephalon7.61e-1434
brain grey matter1.52e-1334
gray matter1.52e-1334
ecto-epithelium1.88e-13104
cerebral hemisphere6.97e-1332
regional part of telencephalon9.78e-1332
regional part of cerebral cortex2.28e-1222
ectoderm-derived structure2.34e-12171
ectoderm2.34e-12171
presumptive ectoderm2.34e-12171
structure with developmental contribution from neural crest4.17e-12132
pre-chordal neural plate8.71e-1261
organ system subdivision1.50e-11223
neocortex1.77e-1120
cerebral cortex4.66e-1025
pallium4.66e-1025
multi-cellular organism9.22e-10656
anatomical system1.36e-08624
organ1.78e-08503
anatomical group2.00e-08625
germ layer4.96e-08560
germ layer / neural crest4.96e-08560
embryonic tissue4.96e-08560
presumptive structure4.96e-08560
germ layer / neural crest derived structure4.96e-08560
epiblast (generic)4.96e-08560
multi-tissue structure7.78e-08342
embryonic structure1.35e-07564


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.16.86157
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.12.44638
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.13.15728
MA0043.11.32783
MA0046.14.71046
MA0048.13.37768
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.990225
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.12.91906
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.12.26598
MA0145.10.273764
MA0146.15.33893
MA0147.12.37462
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.114.6585
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.28.812
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.019084356979464
CTCF#1066435.360256373075030.0064925092527670.0280844588241275
CTCFL#140690319.74647435897440.0001298372005551160.00172213200263853
E2F1#186934.907389214879320.008460985347239390.0327110701369784
E2F6#187635.017155731697390.00791769806886330.032386185274508
EGR1#195834.988179094810140.008056488137383440.0322046757982236
ELF1#199734.258097958807540.01295179875054610.0464389216461234
GABPB1#255337.067683836182170.002832212825417420.0154671342435563
RAD21#5885310.35503389545630.0009004912073565420.00667279702037107
SMARCB1#6598212.16847718743830.008675002221921740.0330093837962358
TFAP2A#7020316.5186343730450.0002218033880766340.00249192384330202
TFAP2C#7022310.80922860986020.0007916746575753130.00618088581614025
YY1#752834.911170749853860.008441455341808260.0330838019529838
ZBTB7A#5134137.35190930787590.002516255860282270.0140742955115692



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.